General Structure Information
| PDB ID | 3e7g |
| HGNC Gene Label(s) | NOS2 |
| Structure Name | structure of human inosox with inhibitor ar-c95791 |
| Resolution | 2.2Å |
| Reference | AUTH E.D.GARCIN,A.S.ARVAI,R.J.ROSENFELD,M.D.KROEGER,AUTH 2 B.R.CRANE,G.ANDERSSON,G.ANDREWS,P.J.HAMLEY,AUTH 3 P.R.MALLINDER,D.J.NICHOLLS,S.A.ST-GALLAY,AUTH 4 A.C.TINKER,N.P.GENSMANTEL,A.METE,D.R.CHESHIRE,AUTH 5 S.CONNOLLY,D.J.STUEHR,A.ABERG,A.V.WALLACE,AUTH 6 J.A.TAINER,E.D.GETZOFFTITL ANCHORED PLASTICITY OPENS DOORS FOR SELECTIVETITL 2 INHIBITOR DESIGN IN NITRIC OXIDE SYNTHASE.REF NAT.CHEM.BIOL. V. 4 700 2008REFN ISSN 1552-4450PMID 18849972DOI 10.1038/NCHEMBIO.115 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 421 |
| Number Of SNVs | 101 |
| Number Of Permutations | 18370 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.176 |
| p-value | 0.026 |
COSMIC
| Number Of Residues | 421 |
| Number Of SNVs | 8 |
| Number Of Permutations | 1190 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.25 |
| p-value | 0.296 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 101 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.115 |
| p-value | 0.299 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
