General Structure Information
| PDB ID | 3hnc |
| HGNC Gene Label(s) | RRM1 |
| Structure Name | crystal structure of human ribonucleotide reductase 1 bound to the effector ttp |
| Resolution | 2.41Å |
| Reference | AUTH J.W.FAIRMAN,S.R.WIJERATHNA,M.F.AHMAD,H.XU,R.NAKANO,S.JHA,AUTH 2 J.PRENDERGAST,R.M.WELIN,S.FLODIN,A.ROOS,P.NORDLUND,Z.LI,AUTH 3 T.WALZ,C.G.DEALWISTITL STRUCTURAL BASIS FOR ALLOSTERIC REGULATION OF HUMANTITL 2 RIBONUCLEOTIDE REDUCTASE BY NUCLEOTIDE-INDUCEDTITL 3 OLIGOMERIZATION.REF NAT.STRUCT.MOL.BIOL. V. 18 316 2011REFN ISSN 1545-9993PMID 21336276DOI 10.1038/NSMB.2007 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 714 |
| Number Of SNVs | 96 |
| Number Of Permutations | 63464 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | 0.331 |
| p-value | 0.151 |
COSMIC
| Number Of Residues | 714 |
| Number Of SNVs | 3 |
| Number Of Permutations | 137 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.333 |
| p-value | 0.379 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
