Assessment of Structural Intolerance and Durability
General Structure Information 1dgn CARD18 solution structure of iceberg, an inhibitor of interleukin- 1beta generation -1.0Å AUTH E.W.HUMKE,S.K.SHRIVER,M.A.STAROVASNIK,AUTH 2 W.J.FAIRBROTHER,V.M.DIXITTITL ICEBERG: A NOVEL INHIBITOR OF INTERLEUKIN-1BETATITL 2 GENERATION.REF CELL(CAMBRIDGE,MASS.) V. 103 99 2000REFN ISSN 0092-8674PMID 11051551DOI 10.1016/S0092-8674(00)00108-2 Variant Set Distributions Mapped Variants
General Structure Information 2ast SKP1 crystal structure of skp1-skp2-cks1 in complex with a p27 peptide 2.3Å AUTH B.HAO,N.ZHENG,B.A.SCHULMAN,G.WU,J.J.MILLER,M.PAGANO,AUTH 2 N.P.PAVLETICHTITL STRUCTURAL BASIS OF THE CKS1-DEPENDENT RECOGNITION OFTITL 2 P27(KIP1) BY THE SCF(SKP2) UBIQUITIN LIGASE.REF MOL.CELL V. 20 9 2005REFN ISSN 1097-2765PMID 16209941DOI 10.1016/J.MOLCEL.2005.09.003 Variant Set Distributions Mapped Variants
General Structure Information 2oj4 RGS3 crystal structure of rgs3 rgs domain 2.3Å AUTH L.REZABKOVA,E.BOURA,P.HERMAN,J.VECER,L.BOUROVA,M.SULC,AUTH 2 P.SVOBODA,V.OBSILOVA,T.OBSILTITL 14-3-3 PROTEIN INTERACTS WITH AND AFFECTS THE STRUCTURE OFTITL 2 RGS DOMAIN OF REGULATOR OF G PROTEIN SIGNALING 3 (RGS3).REF J.STRUCT.BIOL. V. 170 451 2010REFN ISSN 1047-8477PMID 20347994DOI 10.1016/J.JSB.2010.03.009 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1jsu CDKN1B p27(kip1)/cyclin a/cdk2 complex 2.3Å AUTH A.A.RUSSO,P.D.JEFFREY,A.K.PATTEN,J.MASSAGUE,AUTH 2 N.P.PAVLETICHTITL CRYSTAL STRUCTURE OF THE P27KIP1TITL 2 CYCLIN-DEPENDENT-KINASE INHIBITOR BOUND TO THETITL 3 CYCLIN A-CDK2 COMPLEX.REF NATURE V. 382 325 1996REFN ISSN 0028-0836PMID 8684460DOI 10.1038/382325A0 Variant Set Distributions Mapped Variants
General Structure Information 3sxs BMX crystal structure of bmx non-receptor tyrosine kinase complexed with pp2 1.89Å AUTH J.MUCKELBAUER,J.S.SACK,N.AHMED,J.BURKE,C.Y.CHANG,M.GAO,AUTH 2 J.TINO,D.XIE,A.J.TEBBENTITL X-RAY CRYSTAL STRUCTURE OF BONE MARROW KINASE IN THE XTITL 2 CHROMOSOME: A TEC FAMILY KINASE.REF CHEM.BIOL.DRUG DES. V. 78 739 2011REFN ISSN 1747-0277PMID 21883956DOI 10.1111/J.1747-0285.2011.01230.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4hab PLK1 crystal structure of plk1 polo-box domain in complex with pl-49 2.65Å AUTH R.N.MURUGAN,J.E.PARK,D.LIM,M.AHN,C.CHEONG,T.KWON,K.Y.NAM,AUTH 2 S.H.CHOI,B.Y.KIM,D.Y.YOON,M.B.YAFFE,D.Y.YU,K.S.LEE,J.K.BANGTITL DEVELOPMENT OF CYCLIC PEPTOMER INHIBITORS TARGETING THETITL 2 POLO-BOX DOMAIN OF POLO-LIKE KINASE 1.REF BIOORG.MED.CHEM. V. 21 2623 2013REFN ISSN 0968-0896PMID 23498919DOI 10.1016/J.BMC.2013.02.020 Variant Set Distributions Mapped Variants
General Structure Information 1rm8 MMP16 crystal structure of the catalytic domain of mmp-16/mt3- mmp: characterization of mt-mmp specific features 1.8Å AUTH R.LANG,M.BRAUN,N.E.SOUNNI,A.NOEL,F.FRANKENNE,AUTH 2 J.M.FOIDART,W.BODE,K.MASKOSTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OFTITL 2 MMP-16/MT3-MMP: CHARACTERIZATION OF MT-MMPTITL 3 SPECIFIC FEATURES.REF J.MOL.BIOL. V. 336 213 2004REFN ISSN 0022-2836PMID 14741217DOI 10.1016/J.JMB.2003.12.022 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4jg7 RPS6KA3 structure of rsk2 ctd bound to 3-(3-(1h-pyrrolo[2,3-b]pyridine-3- carbonyl)phenyl)-2-cyanoacrylamide 3.0Å AUTH R.M.MILLER,V.O.PAAVILAINEN,S.KRISHNAN,I.M.SERAFIMOVA,AUTH 2 J.TAUNTONTITL ELECTROPHILIC FRAGMENT-BASED DESIGN OF REVERSIBLE COVALENTTITL 2 KINASE INHIBITORS.REF J.AM.CHEM.SOC. V. 135 5298 2013REFN ISSN 0002-7863PMID 23540679DOI 10.1021/JA401221B Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3pdf CTSC discovery of novel cyanamide-based inhibitors of cathepsin c 1.85Å AUTH D.LAINE,M.PALOVICH,P.MCCLELAND,E.PETITJEAN,I.DELHOM,H.XIE,AUTH 2 J.DENG,G.LIN,R.DAVIS,A.JOLIT,N.NEVINS,J.VILLA,J.SCHNECKTITL DISCOVERY OF NOVEL CYANAMIDE-BASED INHIBITORS OF CATHEPSIN CREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3pjc JAK3 crystal structure of jak3 complexed with a potent atp site inhibitor showing high selectivity within the janus kinase family 2.2Å AUTH G.THOMA,F.NUNINGER,R.FALCHETTO,E.HERMES,G.A.TAVARES,AUTH 2 E.VANGREVELINGHE,H.G.ZERWESTITL IDENTIFICATION OF A POTENT JANUS KINASE 3 INHIBITOR WITHTITL 2 HIGH SELECTIVITY WITHIN THE JANUS KINASE FAMILY.REF J.MED.CHEM. V. 54 284 2011REFN ISSN 0022-2623PMID 21155605DOI 10.1021/JM101157Q […]