General Structure Information
| PDB ID | 3pdf |
| HGNC Gene Label(s) | CTSC |
| Structure Name | discovery of novel cyanamide-based inhibitors of cathepsin c |
| Resolution | 1.85Å |
| Reference | AUTH D.LAINE,M.PALOVICH,P.MCCLELAND,E.PETITJEAN,I.DELHOM,H.XIE,AUTH 2 J.DENG,G.LIN,R.DAVIS,A.JOLIT,N.NEVINS,J.VILLA,J.SCHNECKTITL DISCOVERY OF NOVEL CYANAMIDE-BASED INHIBITORS OF CATHEPSIN CREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 349 |
| Number Of SNVs | 98 |
| Number Of Permutations | 46458 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.033 |
| p-value | 0.199 |
ClinVar
| Number Of Residues | 349 |
| Number Of SNVs | 9 |
| Number Of Permutations | 4854 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.417 |
| p-value | 0.99 |
COSMIC
| Number Of Residues | 349 |
| Number Of SNVs | 8 |
| Number Of Permutations | 4602 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.036 |
| p-value | 0.96 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 98 |
| Number Of ClinVar SNVs | 9 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | -0.039 |
| p-value | 0.836 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 98 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | -0.081 |
| p-value | 0.555 |