Assessment of Structural Intolerance and Durability
General Structure Information 2kna XIAP solution structure of uba domain of xiap -1.0Å AUTH S.K.HUI,M.K.TSE,Y.YANG,B.C.WONG,K.H.SZETITL BACKBONE AND SIDE-CHAIN 1H, 13C AND 15N ASSIGNMENTS OF THETITL 2 UBIQUITIN-ASSOCIATED DOMAIN OF HUMAN X-LINKED INHIBITOR OFTITL 3 APOPTOSIS PROTEINREF BIOMOL.NMR ASSIGN. V. 4 13 2010REFN ISSN 1874-2718PMID 19916060DOI 10.1007/S12104-009-9197-X Variant Set Distributions Mapped Variants
General Structure Information 3u9c CSNK2A1 structure of a c-terminal deletion mutant of human protein kinase ck2 catalytic subunit with the atp-competitive inhibitor resorufin 3.2Å AUTH K.KLOPFFLEISCH,O.G.ISSINGER,K.NIEFINDTITL LOW-DENSITY CRYSTAL PACKING OF HUMAN PROTEIN KINASE CK2TITL 2 CATALYTIC SUBUNIT IN COMPLEX WITH RESORUFIN OR OTHERTITL 3 LIGANDS: A TOOL TO STUDY THE UNIQUE HINGE-REGION PLASTICITYTITL 4 OF […]
General Structure Information 2vqv HDAC4 structure of hdac4 catalytic domain with a gain-of-function mutation bound to a hydroxamic acid inhibitor 3.3Å AUTH M.J.BOTTOMLEY,P.LO SURDO,P.DI GIOVINE,A.CIRILLO,AUTH 2 R.SCARPELLI,F.FERRIGNO,P.JONES,P.NEDDERMANN,AUTH 3 R.DE FRANCESCO,C.STEINKUHLER,P.GALLINARI,A.CARFITITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE HUMANTITL 2 HDAC4 CATALYTIC DOMAIN REVEALS A REGULATORYTITL 3 STRUCTURAL ZINC-BINDING DOMAIN.REF J.BIOL.CHEM. V. 283 26694 2008REFN ISSN 0021-9258PMID […]
General Structure Information 1c9q XIAP average nmr solution structure of the bir-2 domain of xiap -1.0Å AUTH C.SUN,M.CAI,A.H.GUNASEKERA,R.P.MEADOWS,H.WANG,AUTH 2 J.CHEN,H.ZHANG,W.WU,N.XU,S.C.NG,S.W.FESIKTITL NMR STRUCTURE AND MUTAGENESIS OF THETITL 2 INHIBITOR-OF-APOPTOSIS PROTEIN XIAP.REF NATURE V. 401 818 1999REFN ISSN 0028-0836PMID 10548111DOI 10.1038/44617 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2leo SPINK7 solution structure of esophageal cancer-related gene 2 -1.0Å AUTH Y.FENG,Y.GENG,T.ZHOU,J.WANGTITL NMR STRUCTURE NOTE: HUMAN ESOPHAGEAL CANCER-RELATED GENE 2REF J.BIOMOL.NMR V. 53 65 2012REFN ISSN 0925-2738PMID 22528291DOI 10.1007/S10858-012-9622-9 Variant Set Distributions Mapped Variants
General Structure Information 1unl CDK5 structural mechanism for the inhibition of cd5-p25 from the roscovitine, aloisine and indirubin. 2.2Å AUTH M.MAPELLI,L.MASSIMILINAO,C.CROVACE,M.A.SEELIGER,L.-H.TSAI,AUTH 2 L.MEIJER,A.MUSACCHIOTITL MECHANISM OF CDK5/P25 BINDING BY CDK INHIBITORSREF J.MED.CHEM. V. 48 671 2005REFN ISSN 0022-2623PMID 15689152DOI 10.1021/JM049323M Variant Set Distributions Mapped Variants
General Structure Information 4f52 RBX1 structure of a glomulin-rbx1-cul1 complex 3.0Å AUTH D.M.DUDA,J.L.OLSZEWSKI,A.E.TRON,M.HAMMEL,L.J.LAMBERT,AUTH 2 M.B.WADDELL,T.MITTAG,J.A.DECAPRIO,B.A.SCHULMANTITL STRUCTURE OF A GLOMULIN-RBX1-CUL1 COMPLEX: INHIBITION OF ATITL 2 RING E3 LIGASE THROUGH MASKING OF ITS E2-BINDING SURFACE.REF MOL.CELL V. 47 371 2012REFN ISSN 1097-2765PMID 22748924DOI 10.1016/J.MOLCEL.2012.05.044 Variant Set Distributions Mapped Variants
General Structure Information 4ie2 ARG2 crystal structure of human arginase-2 complexed with inhibitor 1h 2.21Å AUTH A.GOLEBIOWSKI,R.PAUL BECKETT,M.VAN ZANDT,M.K.JI,AUTH 2 D.WHITEHOUSE,T.R.RYDER,E.JAGDMANN,M.ANDREOLI,A.MAZUR,AUTH 3 M.PADMANILAYAM,A.COUSIDO-SIAH,A.MITSCHLER,F.X.RUIZ,AUTH 4 A.PODJARNY,H.SCHROETERTITL 2-SUBSTITUTED-2-AMINO-6-BORONOHEXANOIC ACIDS AS ARGINASETITL 2 INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 23 2027 2013REFN ISSN 0960-894XPMID 23453840DOI 10.1016/J.BMCL.2013.02.024 Variant Set Distributions Mapped Variants
General Structure Information 3g76 XIAP crystal structure of xiap-bir3 in complex with a bivalent compound 3.0Å AUTH F.COSSU,M.MILANI,E.MASTRANGELO,P.VACHETTE,AUTH 2 F.SERVIDA,D.LECIS,G.CANEVARI,D.DELIA,C.DRAGO,AUTH 3 V.RIZZO,L.MANZONI,P.SENECI,C.SCOLASTICO,M.BOLOGNESITITL STRUCTURAL BASIS FOR BIVALENT SMAC-MIMETICSTITL 2 RECOGNITION IN THE IAP PROTEIN FAMILYREF J.MOL.BIOL. V. 392 630 2009REFN ISSN 0022-2836PMID 19393243DOI 10.1016/J.JMB.2009.04.033 Variant Set Distributions Mapped Variants
General Structure Information 2x7g SRPK2 structure of human serine-arginine-rich protein-specific kinase 2 (srpk2) bound to purvalanol b 2.5Å AUTH A.C.W.PIKE,P.SAVITSKY,O.FEDOROV,T.KROJER,E.UGOCHUKWU,AUTH 2 F.VON DELFT,O.GILEADI,A.EDWARDS,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 C.BOUNTRA,S.KNAPPTITL STRUCTURE OF HUMAN SERINE-ARGININE-RICH PROTEIN- SPECIFICTITL 2 KINASE 2 (SRPK2) BOUND TO PURVALANOL BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants