3F81.B | DUSP3

General Structure Information 3f81 DUSP3 interaction of vhr with sa3 1.9Å AUTH S.WU,S.VOSSIUS,S.RAHMOUNI,A.V.MILETIC,T.VANG,AUTH 2 J.VAZQUEZ-RODRIGUEZ,F.CERIGNOLI,Y.ARIMURA,AUTH 3 S.WILLIAMS,T.HAYES,M.MOUTSCHEN,S.VASILE,AUTH 4 M.PELLECCHIA,T.MUSTELIN,L.TAUTZTITL MULTIDENTATE SMALL-MOLECULE INHIBITORS OF VACCINIATITL 2 H1-RELATED (VHR) PHOSPHATASE DECREASE PROLIFERATIONTITL 3 OF CERVIX CANCER CELLS.REF J.MED.CHEM. V. 52 6716 2009REFN ISSN 0022-2623PMID 19888758DOI 10.1021/JM901016K Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]

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1AV5.B | HINT1

General Structure Information 1av5 HINT1 pkci-substrate analog 2.0Å AUTH C.D.LIMA,M.G.KLEIN,W.A.HENDRICKSONTITL STRUCTURE-BASED ANALYSIS OF CATALYSIS ANDTITL 2 SUBSTRATE DEFINITION IN THE HIT PROTEIN FAMILY.REF SCIENCE V. 278 286 1997REFN ISSN 0036-8075PMID 9323207DOI 10.1126/SCIENCE.278.5336.286 Variant Set Distributions Mapped Variants

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4KBC.A | CSNK1D

General Structure Information 4kbc CSNK1D ck1d in complex with {4-[3-(4-fluorophenyl)-1h-pyrazol-4-yl]pyridin-2- yl}methanol inhibitor 1.98Å AUTH S.MENTE,E.ARNOLD,T.BUTLER,S.CHAKRAPANI,R.CHANDRASEKARAN,AUTH 2 K.CHERRY,K.DIRICO,A.DORAN,K.FISHER,P.GALATSIS,M.GREEN,AUTH 3 M.HAYWARD,J.HUMPHREY,J.KNAFELS,J.LI,S.LIU,M.MARCONI,AUTH 4 S.MCDONALD,J.OHREN,V.PARADIS,B.SNEED,K.WALTON,T.WAGERTITL LIGAND-PROTEIN INTERACTIONS OF SELECTIVE CASEIN KINASE 1TITL 2 DELTA INHIBITORS.REF J.MED.CHEM. V. 56 6819 2013REFN ISSN 0022-2623PMID 23919824DOI 10.1021/JM4006324 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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2ZKS.A | GZMM

General Structure Information 2zks GZMM structural insights into the proteolytic machinery of apoptosis- inducing granzyme m 2.7Å AUTH L.WU,L.WANG,G.HUA,K.LIU,X.YANG,Y.ZHAI,M.BARTLAM,F.SUN,Z.FANTITL STRUCTURAL BASIS FOR PROTEOLYTIC SPECIFICITY OF THE HUMANTITL 2 APOPTOSIS-INDUCING GRANZYME MREF J.IMMUNOL. V. 183 421 2009REFN ISSN 0022-1767PMID 19542453DOI 10.4049/JIMMUNOL.0803088 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants

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4JA8.B | IDH2

General Structure Information 4ja8 IDH2 complex of mitochondrial isocitrate dehydrogenase r140q mutant with agi-6780 inhibitor 1.55Å AUTH F.WANG,J.TRAVINS,B.DELABARRE,V.PENARD-LACRONIQUE,S.SCHALM,AUTH 2 E.HANSEN,K.STRALEY,A.KERNYTSKY,W.LIU,C.GLISER,H.YANG,AUTH 3 S.GROSS,E.ARTIN,V.SAADA,E.MYLONAS,C.QUIVORON,AUTH 4 J.POPOVICI-MULLER,J.O.SAUNDERS,F.G.SALITURO,S.YAN,S.MURRAY,AUTH 5 W.WEI,Y.GAO,L.DANG,M.DORSCH,S.AGRESTA,D.P.SCHENKEIN,AUTH 6 S.A.BILLER,S.M.SU,S.DE BOTTON,K.E.YENTITL TARGETED INHIBITION OF MUTANT IDH2 IN LEUKEMIA CELLS INDUCESTITL 2 CELLULAR DIFFERENTIATION.REF SCIENCE V. 340 622 2013REFN ISSN 0036-8075PMID 23558173DOI 10.1126/SCIENCE.1234769 Variant Set Distributions Ripley’s K […]

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1ONI.E | HRSP12

General Structure Information 1oni HRSP12 crystal structure of a human p14.5, a translational inhibitor reveals different mode of ligand binding near the invariant residues of the yjgf/uk114 protein family 1.9Å AUTH B.A.MANJASETTY,H.DELBRUCK,D.T.PHAM,U.MUELLER,AUTH 2 M.FIEBER-ERDMANN,C.SCHEICH,V.SIEVERT,K.BUSSOW,F.H.NIESEN,AUTH 3 W.WEIHOFEN,B.LOLL,W.SAENGER,U.HEINEMANN,F.H.NEISENTITL CRYSTAL STRUCTURE OF HOMO SAPIENS PROTEIN HP14.5.REF PROTEINS V. 54 797 2004REFN ISSN 0887-3585PMID 14997576DOI 10.1002/PROT.10619 Variant Set Distributions […]

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3TL5.A | PIK3CG

General Structure Information 3tl5 PIK3CG discovery of gdc-0980: a potent, selective, and orally available class i phosphatidylinositol 3-kinase (pi3k)/mammalian target of rapamycin (mtor) kinase inhibitor for the treatment of cancer 2.79Å AUTH D.P.SUTHERLIN,L.BAO,M.BERRY,G.CASTANEDO,I.CHUCKOWREE,AUTH 2 J.DOTSON,A.FOLKS,L.FRIEDMAN,R.GOLDSMITH,J.GUNZNER,T.HEFFRON,AUTH 3 J.LESNICK,C.LEWIS,S.MATHIEU,J.MURRAY,J.NONOMIYA,J.PANG,AUTH 4 N.PEGG,W.W.PRIOR,L.ROUGE,L.SALPHATI,D.SAMPATH,Q.TIAN,V.TSUI,AUTH 5 N.C.WAN,S.WANG,B.WEI,C.WIESMANN,P.WU,B.Y.ZHU,A.OLIVEROTITL DISCOVERY OF A POTENT, SELECTIVE, AND ORALLY AVAILABLE CLASSTITL 2 I PHOSPHATIDYLINOSITOL 3-KINASE (PI3K)/MAMMALIAN […]

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1ZR0.B | TFPI2

General Structure Information 1zr0 TFPI2 crystal structure of kunitz domain 1 of tissue factor pathway inhibitor-2 with bovine trypsin 1.8Å AUTH A.E.SCHMIDT,H.S.CHAND,D.CASCIO,W.KISIEL,S.P.BAJAJTITL CRYSTAL STRUCTURE OF KUNITZ DOMAIN 1 (KD1) OFTITL 2 TISSUE FACTOR PATHWAY INHIBITOR-2 IN COMPLEX WITHTITL 3 TRYPSIN. IMPLICATIONS FOR KD1 SPECIFICITY OFTITL 4 INHIBITIONREF J.BIOL.CHEM. V. 280 27832 2005REFN ISSN 0021-9258PMID 15932872DOI […]

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4NW5.A | RPS6KA3

General Structure Information 4nw5 RPS6KA3 rsk2 n-terminal kinase in complex with 2-amino-7-substituted benzoxazole compound 8 1.94Å AUTH A.COSTALES,M.MATHUR,S.RAMURTHY,J.LAN,S.SUBRAMANIAN,R.JAIN,AUTH 2 G.ATALLAH,L.SETTI,M.LINDVALL,B.A.APPLETON,E.ORNELAS,AUTH 3 P.FEUCHT,B.WARNE,L.DOYLE,S.E.BASHAM,I.ARONCHIK,AUTH 4 A.B.JEFFERSON,C.M.SHAFERTITL 2-AMINO-7-SUBSTITUTED BENZOXAZOLE ANALOGS AS POTENT RSK2TITL 2 INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 24 1592 2014REFN ISSN 0960-894XPMID 24534486DOI 10.1016/J.BMCL.2014.01.058 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]

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1BQQ.M | MMP14

General Structure Information 1bqq MMP14 crystal structure of the mt1-mmp–timp-2 complex 2.75Å AUTH C.FERNANDEZ-CATALAN,W.BODE,R.HUBER,D.TURK,AUTH 2 J.J.CALVETE,A.LICHTE,H.TSCHESCHE,K.MASKOSTITL CRYSTAL STRUCTURE OF THE COMPLEX FORMED BY THETITL 2 MEMBRANE TYPE 1-MATRIX METALLOPROTEINASE WITH THETITL 3 TISSUE INHIBITOR OF METALLOPROTEINASES-2, THETITL 4 SOLUBLE PROGELATINASE A RECEPTOR.REF EMBO J. V. 17 5238 1998REFN ISSN 0261-4189PMID 9724659DOI 10.1093/EMBOJ/17.17.5238 Variant Set Distributions […]

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