1GMY.A | CTSB

General Structure Information 1gmy CTSB cathepsin b complexed with dipeptidyl nitrile inhibitor 1.9Å AUTH P.D.GREENSPAN,K.L.CLARK,R.A.TOMMASI,S.D.COWEN,AUTH 2 L.W.MCQUIRE,D.L.FARLEY,J.H.VAN DUZER,R.L.GOLDBERG,AUTH 3 H.ZHOU,Z.DU,J.J.FITT,D.E.COPPA,Z.FANG,W.MACCHIA,AUTH 4 L.ZHU,M.P.CAPPARELLI,R.GOLDSTEIN,A.M.WIGG,AUTH 5 J.R.DOUGHTY,R.S BOHACEK,A.K.KNAPTITL IDENTIFICATION OF DIPEPTIDYL NITRILES AS POTENTTITL 2 AND SELECTIVE INHIBITORS OF CATHEPSIN B THROUGHTITL 3 STRUCTURE-BASED DRUG DESIGNREF J.MED.CHEM. V. 44 4524 2001REFN ISSN 0022-2623PMID 11741472DOI 10.1021/JM010206Q Variant Set Distributions […]

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2Y5L.C | FBP1

General Structure Information 2y5l FBP1 orally active aminopyridines as inhibitors of tetrameric fructose 1,6-bisphosphatase 2.2Å AUTH P.HEBEISEN,W.HAAP,B.KUHN,P.MOHR,H.P.WESSEL,U.ZUTTER,AUTH 2 S.KIRCHNER,A.RUF,J.BENZ,C.JOSEPH,R.ALVAREZ-SANCHEZ,M.GUBLER,AUTH 3 B.SCHOTT,A.BENARDEAU,E.TOZZO,E.KITASTITL ORALLY ACTIVE AMINOPYRIDINES AS INHIBITORS OF TETRAMERICTITL 2 FRUCTOSE-1,6-BISPHOSPHATASE.REF BIOORG.MED.CHEM.LETT. V. 21 3237 2011REFN ISSN 0960-894XPMID 21550236DOI 10.1016/J.BMCL.2011.04.044 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants

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1SPJ.A | KLK1

General Structure Information 1spj KLK1 structure of mature human tissue kallikrein (human kallikrein 1 or klk1) at 1.70 angstrom resolution with vacant active site 1.7Å AUTH G.LAXMIKANTHAN,S.I.BLABER,M.J.BERNETT,I.A.SCARISBRICK,AUTH 2 M.A.JULIANO,M.BLABERTITL 1.70 A X-RAY STRUCTURE OF HUMAN APO KALLIKREIN 1: STRUCTURALTITL 2 CHANGES UPON PEPTIDE INHIBITOR/SUBSTRATE BINDINGREF PROTEINS V. 58 802 2005REFN ISSN 0887-3585PMID 15651049DOI 10.1002/PROT.20368 Variant […]

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1KYN.B | CTSG

General Structure Information 1kyn CTSG cathepsin-g 3.5Å AUTH M.N.GRECO,M.J.HAWKINS,E.T.POWELL,H.R.ALMOND JR.,AUTH 2 T.W.CORCORAN,L.DE GARAVILLA,J.A.KAUFFMAN,R.RECACHA,AUTH 3 D.CHATTOPADHYAY,P.ANDRADE-GORDON,B.E.MARYANOFFTITL NONPEPTIDE INHIBITORS OF CATHEPSIN G: OPTIMIZATIONTITL 2 OF A NOVEL BETA-KETOPHOSPHONIC ACID LEAD BYTITL 3 STRUCTURE-BASED DRUG DESIGN.REF J.AM.CHEM.SOC. V. 124 3810 2002REFN ISSN 0002-7863PMID 11942800DOI 10.1021/JA017506H Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants

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3TH4.H | F7

General Structure Information 3th4 F7 mg2+ is required for optimal folding of the gamma-carboxyglutamic acid (gla) domains of vitamin k-dependent clotting factors at physiological ca2+ 1.8Å AUTH K.VADIVEL,S.AGAH,A.MESSER,D.CASCIO,S.M.BAJAJ,S.KRISHNASWAMY,AUTH 2 C.T.ESMON,K.PADMANABHAN,S.P.BAJAJTITL MG2+ IS REQUIRED FOR OPTIMAL FOLDING OF THETITL 2 GAMMA-CARBOXYGLUTAMIC ACID (GLA) DOMAINS OF VITAMINTITL 3 K-DEPENDENT CLOTTING FACTORS AT PHYSIOLOGICAL CA2+REF TO BE PUBLISHEDREFN […]

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2WSL.A | BCHE

General Structure Information 2wsl BCHE aged form of human butyrylcholinesterase inhibited by tabun analogue ta4 2.0Å AUTH E.CARLETTI,N.AURBEK,E.GILLON,M.LOIODICE,Y.NICOLET,AUTH 2 J.C.FONTECILLA-CAMPS,P.MASSON,H.THIERMANN,F.NACHON,F.WOREKTITL STRUCTURE-ACTIVITY ANALYSIS OF AGING AND REACTIVATION OFTITL 2 HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY ANALOGUES OFTITL 3 TABUN.REF BIOCHEM.J. V. 421 97 2009REFN ISSN 0264-6021PMID 19368529DOI 10.1042/BJ20090091 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]

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1P49.A | STS

General Structure Information 1p49 STS structure of human placental estrone/dhea sulfatase 2.6Å AUTH F.G.HERNANDEZ-GUZMAN,T.HIGASHIYAMA,W.PANGBORN,Y.OSAWA,AUTH 2 D.GHOSHTITL STRUCTURE OF HUMAN ESTRONE SULFATASE SUGGESTS FUNCTIONALTITL 2 ROLES OF MEMBRANE ASSOCIATIONREF J.BIOL.CHEM. V. 278 22989 2003REFN ISSN 0021-9258PMID 12657638DOI 10.1074/JBC.M211497200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants

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3FCX.A | ESD

General Structure Information 3fcx ESD crystal structure of human esterase d 1.5Å AUTH D.WU,Y.LI,G.SONG,D.ZHANG,N.SHAW,Z.J.LIUTITL CRYSTAL STRUCTURE OF HUMAN ESTERASE D: A POTENTIALTITL 2 GENETIC MARKER OF RETINOBLASTOMAREF FASEB J. V. 23 1441 2009REFN ISSN 0892-6638PMID 19126594DOI 10.1096/FJ.08-125286 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants

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4J1Y.A | C1S

General Structure Information 4j1y C1S the x-ray crystal structure of human complement protease c1s zymogen 2.66Å AUTH A.J.PERRY,L.C.WIJEYEWICKREMA,P.G.WILMANN,M.J.GUNZBURG,AUTH 2 L.DANDREA,J.A.IRVING,S.S.PANG,R.C.DUNCAN,J.A.WILCE,AUTH 3 J.C.WHISSTOCK,R.N.PIKETITL A MOLECULAR SWITCH GOVERNS THE INTERACTION BETWEEN THE HUMANTITL 2 COMPLEMENT PROTEASE C1S AND ITS SUBSTRATE, COMPLEMENT C4.REF J.BIOL.CHEM. V. 288 15821 2013REFN ISSN 0021-9258PMID 23592783DOI 10.1074/JBC.M113.464545 Variant Set Distributions Ripley’s K Analysis […]

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2C01.X | RNASE2

General Structure Information 2c01 RNASE2 crystal structures of eosinophil-derived neurotoxin in complex with the inhibitors 5-atp, ap3a, ap4a and ap5a 1.24Å AUTH M.D.BAKER,D.E.HOLLOWAY,G.J.SWAMINATHAN,K.R.ACHARYATITL CRYSTAL STRUCTURES OF EOSINOPHIL-DERIVEDTITL 2 NEUROTOXIN (EDN) IN COMPLEX WITH THE INHIBITORSTITL 3 5- ATP, AP(3)A, AP(4)A, AND AP(5)A.REF BIOCHEMISTRY V. 45 416 2006REFN ISSN 0006-2960PMID 16401072DOI 10.1021/BI0518592 Variant Set Distributions Mapped […]

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