General Structure Information
| PDB ID | 1spj |
| HGNC Gene Label(s) | KLK1 |
| Structure Name | structure of mature human tissue kallikrein (human kallikrein 1 or klk1) at 1.70 angstrom resolution with vacant active site |
| Resolution | 1.7Å |
| Reference | AUTH G.LAXMIKANTHAN,S.I.BLABER,M.J.BERNETT,I.A.SCARISBRICK,AUTH 2 M.A.JULIANO,M.BLABERTITL 1.70 A X-RAY STRUCTURE OF HUMAN APO KALLIKREIN 1: STRUCTURALTITL 2 CHANGES UPON PEPTIDE INHIBITOR/SUBSTRATE BINDINGREF PROTEINS V. 58 802 2005REFN ISSN 0887-3585PMID 15651049DOI 10.1002/PROT.20368 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 223 |
| Number Of SNVs | 59 |
| Number Of Permutations | 6010 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.182 |
| p-value | 0.585 |
COSMIC
| Number Of Residues | 223 |
| Number Of SNVs | 6 |
| Number Of Permutations | 896 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.267 |
| p-value | 0.021 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 59 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.153 |
| p-value | 0.221 |