Assessment of Structural Intolerance and Durability
General Structure Information 1cjl CTSL crystal structure of a cysteine protease proform 2.2Å AUTH R.COULOMBE,P.GROCHULSKI,J.SIVARAMAN,R.MENARD,AUTH 2 J.S.MORT,M.CYGLERTITL STRUCTURE OF HUMAN PROCATHEPSIN L REVEALS THETITL 2 MOLECULAR BASIS OF INHIBITION BY THE PROSEGMENT.REF EMBO J. V. 15 5492 1996REFN ISSN 0261-4189PMID 8896443 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1i71 LPA high resolution crystal structure of apolipoprotein(a) kringle iv type 7: insights into ligand binding 1.45Å AUTH Q.YE,M.N.RAHMAN,M.L.KOSCHINSKY,Z.JIATITL HIGH-RESOLUTION CRYSTAL STRUCTURE OFTITL 2 APOLIPOPROTEIN(A) KRINGLE IV TYPE 7: INSIGHTS INTOTITL 3 LIGAND BINDING.REF PROTEIN SCI. V. 10 1124 2001REFN ISSN 0961-8368PMID 11369850DOI 10.1110/PS.01701 Variant Set Distributions Mapped Variants
General Structure Information 1zcm CAPN1 human calpain protease core inhibited by zllych2f 2.0Å AUTH Q.LI,R.P.HANZLIK,R.F.WEAVER,E.SCHONBRUNNTITL MOLECULAR MODE OF ACTION OF A COVALENTLYTITL 2 INHIBITING PEPTIDOMIMETIC ON THE HUMAN CALPAINTITL 3 PROTEASE COREREF BIOCHEMISTRY V. 45 701 2006REFN ISSN 0006-2960PMID 16411745DOI 10.1021/BI052077B Variant Set Distributions Mapped Variants
General Structure Information 1lar PTPRF crystal structure of the tandem phosphatase domains of rptp lar 2.0Å AUTH H.J.NAM,F.POY,N.X.KRUEGER,H.SAITO,C.A.FREDERICKTITL CRYSTAL STRUCTURE OF THE TANDEM PHOSPHATASETITL 2 DOMAINS OF RPTP LAR.REF CELL(CAMBRIDGE,MASS.) V. 97 449 1999REFN ISSN 0092-8674PMID 10338209DOI 10.1016/S0092-8674(00)80755-2 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2feb LPA nmr solution structure, dynamics and binding properties of the kringle iv type 8 module of apolipoprotein(a) -1.0Å AUTH S.CHITAYAT,V.KANELIS,M.L.KOSCHINSKY,S.P.SMITHTITL NUCLEAR MAGNETIC RESONANCE (NMR) SOLUTIONTITL 2 STRUCTURE, DYNAMICS, AND BINDING PROPERTIES OF THETITL 3 KRINGLE IV TYPE 8 MODULE OF APOLIPOPROTEIN(A).REF BIOCHEMISTRY V. 46 1732 2007REFN ISSN 0006-2960PMID 17263558DOI 10.1021/BI061814G Variant […]
General Structure Information 3lxc GLA interconversion of human lysosomal enzyme specificities 2.35Å AUTH I.B.TOMASIC,M.C.METCALF,A.I.GUCE,N.E.CLARK,S.C.GARMANTITL INTERCONVERSION OF THE SPECIFICITIES OF HUMAN LYSOSOMALTITL 2 ENZYMES ASSOCIATED WITH FABRY AND SCHINDLER DISEASES.REF J.BIOL.CHEM. V. 285 21560 2010REFN ISSN 0021-9258PMID 20444686DOI 10.1074/JBC.M110.118588 Variant Set Distributions Mapped Variants
General Structure Information 4dm9 UCHL1 the crystal structure of ubiquitin carboxy-terminal hydrolase l1 (uchl1) bound to a tripeptide fluoromethyl ketone z-vae(ome)-fmk 2.35Å AUTH C.W.DAVIES,J.CHANEY,G.KORBEL,D.RINGE,G.A.PETSKO,H.PLOEGH,AUTH 2 C.DASTITL THE CO-CRYSTAL STRUCTURE OF UBIQUITIN CARBOXY-TERMINALTITL 2 HYDROLASE L1 (UCHL1) WITH A TRIPEPTIDE FLUOROMETHYL KETONETITL 3 (Z-VAE(OME)-FMK).REF BIOORG.MED.CHEM.LETT. V. 22 3900 2012REFN ISSN 0960-894XPMID 22617491DOI 10.1016/J.BMCL.2012.04.124 Variant Set Distributions […]
General Structure Information 1dig MTHFD1 human methylenetetrahydrofolate dehydrogenase / cyclohydrolase complexed with nadp and inhibitor ly374571 2.2Å AUTH A.SCHMIDT,H.WU,R.E.MACKENZIE,V.J.CHEN,J.R.BEWLY,AUTH 2 J.E.RAY,J.E.TOTH,M.CYGLERTITL STRUCTURES OF THREE INHIBITOR COMPLEXES PROVIDETITL 2 INSIGHT INTO THE REACTION MECHANISM OF THE HUMANTITL 3 METHYLENETETRAHYDROFOLATETITL 4 DEHYDROGENASE/CYCLOHYDROLASE.REF BIOCHEMISTRY V. 39 6325 2000REFN ISSN 0006-2960PMID 10828945DOI 10.1021/BI992734Y Variant Set Distributions Mapped Variants
General Structure Information 1woj CNP crystal structure of human phosphodiesterase 1.8Å AUTH Y.SAKAMOTO,N.TANAKA,T.ICHIMIYA,T.KURIHARA,AUTH 2 K.T.NAKAMURATITL CRYSTAL STRUCTURE OF THE CATALYTIC FRAGMENT OFTITL 2 HUMAN BRAIN 2,3-CYCLIC-NUCLEOTIDETITL 3 3-PHOSPHODIESTERASEREF J.MOL.BIOL. V. 346 789 2005REFN ISSN 0022-2836PMID 15713463DOI 10.1016/J.JMB.2004.12.024 Variant Set Distributions Mapped Variants
General Structure Information 2e0m RNASE1 mutant human ribonuclease 1 (t24l, q28l, r31l, r32l) 1.7Å AUTH H.YAMADA,T.TAMADA,M.KOSAKA,K.MIYATA,S.FUJIKI,M.TANO,AUTH 2 M.MORIYA,M.YAMANISHI,E.HONJO,H.TADA,T.INO,H.YAMAGUCHI,AUTH 3 J.FUTAMI,M.SENO,T.NOMOTO,T.HIRATA,M.YOSHIMURA,R.KUROKITITL CRYSTAL LATTICE ENGINEERING, AN APPROACH TO ENGINEERTITL 2 PROTEIN CRYSTAL CONTACTS BY CREATING INTERMOLECULARTITL 3 SYMMETRY: CRYSTALLIZATION AND STRUCTURE DETERMINATION OF ATITL 4 MUTANT HUMAN RNASE 1 WITH A HYDROPHOBIC INTERFACE OFTITL 5 LEUCINESREF PROTEIN […]