Assessment of Structural Intolerance and Durability
General Structure Information 1fsu ARSB 4-sulfatase (human) 2.5Å AUTH C.S.BOND,P.R.CLEMENTS,S.J.ASHBY,C.A.COLLYER,S.J.HARROP,AUTH 2 J.J.HOPWOOD,J.M.GUSSTITL STRUCTURE OF A HUMAN LYSOSOMAL SULFATASE.REF STRUCTURE V. 5 277 1997REFN ISSN 0969-2126PMID 9032078DOI 10.1016/S0969-2126(97)00185-8 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3lpo SI crystal structure of the n-terminal domain of sucrase-isomaltase 3.2Å AUTH L.SIM,C.WILLEMSMA,S.MOHAN,H.Y.NAIM,B.M.PINTO,D.R.ROSETITL STRUCTURAL BASIS FOR SUBSTRATE SELECTIVITY IN HUMANTITL 2 MALTASE-GLUCOAMYLASE AND SUCRASE-ISOMALTASE N-TERMINALTITL 3 DOMAINS.REF J.BIOL.CHEM. V. 285 17763 2010REFN ISSN 0021-9258PMID 20356844DOI 10.1074/JBC.M109.078980 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fbn PLCG1 insights into structural integration of the plcgamma regulatory region and mechanism of autoinhibition and activation based on key roles of sh2 domains 2.4Å AUTH T.D.BUNNEY,D.ESPOSITO,C.MAS-DROUX,E.LAMBER,R.W.BAXENDALE,AUTH 2 M.MARTINS,A.COLE,D.SVERGUN,P.C.DRISCOLL,M.KATANTITL STRUCTURAL AND FUNCTIONAL INTEGRATION OF THE PLCGAMMATITL 2 INTERACTION DOMAINS CRITICAL FOR REGULATORY MECHANISMS ANDTITL 3 SIGNALING DEREGULATION.REF STRUCTURE V. 20 2062 2012REFN […]
General Structure Information 3edh BMP1 crystal structure of bone morphogenetic protein 1 protease domain in complex with partially bound dmso 1.25Å AUTH A.MAC SWEENEY,S.G.PARRADO,D.VINZENZ,A.BERNARDI,AUTH 2 A.HEIN,U.BODENDORF,P.ERBEL,C.LOGEL,B.GERHARTZTITL STRUCTURAL BASIS FOR THE SUBSTRATE SPECIFICITY OFTITL 2 BONE MORPHOGENETIC PROTEIN 1/TOLLOID-LIKETITL 3 METALLOPROTEASESREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4gdx GGT1 crystal structure of human gamma-glutamyl transpeptidase–glutamate complex 1.67Å AUTH M.B.WEST,Y.CHEN,S.WICKHAM,A.HEROUX,K.CAHILL,M.H.HANIGAN,AUTH 2 B.H.MOOERSTITL NOVEL INSIGHTS INTO EUKARYOTIC GAMMA-GLUTAMYLTRANSPEPTIDASETITL 2 1 FROM THE CRYSTAL STRUCTURE OF THE GLUTAMATE-BOUND HUMANTITL 3 ENZYME.REF J.BIOL.CHEM. V. 288 31902 2013REFN ISSN 0021-9258PMID 24047895DOI 10.1074/JBC.M113.498139 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4gdx GGT1 crystal structure of human gamma-glutamyl transpeptidase–glutamate complex 1.67Å AUTH M.B.WEST,Y.CHEN,S.WICKHAM,A.HEROUX,K.CAHILL,M.H.HANIGAN,AUTH 2 B.H.MOOERSTITL NOVEL INSIGHTS INTO EUKARYOTIC GAMMA-GLUTAMYLTRANSPEPTIDASETITL 2 1 FROM THE CRYSTAL STRUCTURE OF THE GLUTAMATE-BOUND HUMANTITL 3 ENZYME.REF J.BIOL.CHEM. V. 288 31902 2013REFN ISSN 0021-9258PMID 24047895DOI 10.1074/JBC.M113.498139 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1r1j MME structural analysis of neprilysin with various specific and potent inhibitors 2.35Å AUTH C.OEFNER,B.P.ROQUES,M.C.FOURNIE-ZALUSKI,G.E.DALETITL STRUCTURAL ANALYSIS OF NEPRILYSIN WITH VARIOUS SPECIFIC ANDTITL 2 POTENT INHIBITORS.REF ACTA CRYSTALLOGR.,SECT.D V. 60 392 2004REFN ISSN 0907-4449PMID 14747736DOI 10.1107/S0907444903027410 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2vh7 ACYP1 crystal structure of human common-type acylphosphatase 1.45Å AUTH S.Y.LAM,R.C.Y.YEUNG,T.YU,K.SZE,K.B.WONGTITL A RIGIDIFYING SALT-BRIDGE FAVORS THE ACTIVITY OFTITL 2 THERMOPHILIC ENZYME AT HIGH TEMPERATURES AT THE EXPENSE OFTITL 3 LOW-TEMPERATURE ACTIVITY.REF PLOS BIOL. V. 9 1027 2011REFN ISSN 1544-9173PMID 21423654DOI 10.1371/JOURNAL.PBIO.1001027 Variant Set Distributions Mapped Variants
General Structure Information 1z00 ERCC1 solution structure of the c-terminal domain of ercc1 complexed with the c-terminal domain of xpf -1.0Å AUTH K.TRIPSIANES,G.FOLKERS,E.AB,D.DAS,H.ODIJK,AUTH 2 N.G.J.JASPERS,J.H.J.HOEIJMAKERS,R.KAPTEIN,R.BOELENSTITL THE STRUCTURE OF THE HUMAN ERCC1/XPF INTERACTIONTITL 2 DOMAINS REVEALS A COMPLEMENTARY ROLE FOR THE TWOTITL 3 PROTEINS IN NUCLEOTIDE EXCISION REPAIRREF STRUCTURE V. 13 1849 2005REFN ISSN 0969-2126PMID 16338413DOI […]
General Structure Information 1hlg LIPF crystal structure of human gastric lipase 3.0Å AUTH A.ROUSSEL,S.CANAAN,M.P.EGLOFF,M.RIVIERE,L.DUPUIS,R.VERGER,AUTH 2 C.CAMBILLAUTITL CRYSTAL STRUCTURE OF HUMAN GASTRIC LIPASE AND MODEL OFTITL 2 LYSOSOMAL ACID LIPASE, TWO LIPOLYTIC ENZYMES OF MEDICALTITL 3 INTEREST.REF J.BIOL.CHEM. V. 274 16995 1999REFN ISSN 0021-9258PMID 10358049DOI 10.1074/JBC.274.24.16995 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]