Assessment of Structural Intolerance and Durability
General Structure Information 1uwy CPM crystal structure of human carboxypeptidase m 3.0Å AUTH D.REVERTER,K.MASKOS,F.TAN,R.SKIDGEL,W.BODETITL CRYSTAL STRUCTURE OF HUMAN CARBOXYPEPTIDASE M, ATITL 2 MEMBRANE-BOUND ENZYME THAT REGULATES PEPTIDETITL 3 HORMONE ACTIVITYREF J.MOL.BIOL. V. 338 257 2004REFN ISSN 0022-2836PMID 15066430DOI 10.1016/J.JMB.2004.02.058 Variant Set Distributions Mapped Variants
General Structure Information 2xy9 ACE human angiotensin converting enzyme in complex with phosphinic tripeptide 1.97Å AUTH M.AKIF,S.L.SCHWAGER,C.S.ANTHONY,B.CZARNY,F.BEAU,V.DIVE,AUTH 2 E.D.STURROCK,K.R.ACHARYATITL NOVEL MECHANISM OF INHIBITION OF HUMAN ANGIOTENSIN-TITL 2 I-CONVERTING ENZYME (ACE) BY A HIGHLY SPECIFIC PHOSPHINICTITL 3 TRIPEPTIDE.REF BIOCHEM.J. V. 436 53 2011REFN ISSN 0264-6021PMID 21352096DOI 10.1042/BJ20102123 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1tzs CTSE crystal structure of an activation intermediate of cathepsin e 2.35Å AUTH N.OSTERMANN,B.GERHARTZ,S.WORPENBERG,J.TRAPPE,J.EDERTITL CRYSTAL STRUCTURE OF AN ACTIVATION INTERMEDIATE OFTITL 2 CATHEPSIN EREF J.MOL.BIOL. V. 342 889 2004REFN ISSN 0022-2836PMID 15342244DOI 10.1016/J.JMB.2004.07.073 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2c6f ACE structure of human somatic angiontensin-i converting enzyme n domain 3.01Å AUTH H.R.CORRADI,S.L.U.SCHWAGER,A.T.NCHINDA,AUTH 2 E.D.STURROCK,K.R.ACHARYATITL CRYSTAL STRUCTURE OF THE N DOMAIN OF HUMAN SOMATICTITL 2 ANGIOTENSIN I-CONVERTING ENZYME PROVIDES ATITL 3 STRUCTURAL BASIS FOR DOMAIN-SPECIFIC INHIBITORTITL 4 DESIGN.REF J.MOL.BIOL. V. 357 964 2006REFN ISSN 0022-2836PMID 16476442DOI 10.1016/J.JMB.2006.01.048 Variant Set Distributions Ripley’s […]
General Structure Information 1dyt RNASE3 x-ray crystal structure of ecp (rnase 3) at 1.75 a 1.75Å AUTH G.MALLORQUI-FERNANDEZ,J.POUS,R.PERACAULA,T.MAEDA,AUTH 2 H.TADA,H.YAMADA,M.SENO,R.DE LLORENS,AUTH 3 F.X.GOMIS-RUETH,M.COLLTITL THREE-DIMENSIONAL CRYSTAL STRUCTURE OF HUMANTITL 2 EOSINOPHIL CATIONIC PROTEIN (RNASE 3) AT 1.75 ATITL 3 RESOLUTION.REF J.MOL.BIOL. V. 300 1297 2000REFN ISSN 0022-2836PMID 10903870DOI 10.1006/JMBI.2000.3939 Variant Set Distributions Mapped Variants
General Structure Information 1k6m PFKFB1 crystal structure of human liver 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2.4Å AUTH Y.H.LEE,Y.LI,K.UYEDA,C.A.HASEMANNTITL TISSUE-SPECIFIC STRUCTURE/FUNCTION DIFFERENTIATION OF THETITL 2 LIVER ISOFORM OFTITL 3 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE.REF J.BIOL.CHEM. V. 278 523 2003REFN ISSN 0021-9258PMID 12379646DOI 10.1074/JBC.M209105200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2wk3 IDE crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-42) 2.59Å AUTH Q.GUO,M.MANOLOPOULOU,Y.BIAN,A.B.SCHILLING,W.J.TANGTITL MOLECULAR BASIS FOR THE RECOGNITION AND CLEAVAGESTITL 2 OF IGF-II, TGF-ALPHA, AND AMYLIN BY HUMAN INSULINTITL 3 DEGRADING ENZYME.REF J.MOL.BIOL. V. 395 430 2010REFN ISSN 0022-2836PMID 19896952DOI 10.1016/J.JMB.2009.10.072 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1op8 GZMA crystal structure of human granzyme a 2.5Å AUTH C.HINK-SCHAUER,E.ESTEBANEZ-PERPINA,F.KURSCHUS,AUTH 2 W.BODE,D.JENNETITL CRYSTAL STRUCTURE OF THE APOPTOSIS-INDUCING HUMANTITL 2 GRANZYME A DIMERREF NAT.STRUCT.BIOL. V. 10 535 2003REFN ISSN 1072-8368PMID 12819770DOI 10.1038/NSB945 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2nsm CPN1 crystal structure of the human carboxypeptidase n (kininase i) catalytic domain 2.1Å AUTH C.KEIL,K.MASKOS,M.THAN,J.T.HOOPES,R.HUBER,F.TAN,P.A.DEDDISH,AUTH 2 E.G.ERDOES,R.A.SKIDGEL,W.BODETITL CRYSTAL STRUCTURE OF THE HUMAN CARBOXYPEPTIDASE N (KININASETITL 2 I) CATALYTIC DOMAINREF J.MOL.BIOL. V. 366 504 2007REFN ISSN 0022-2836PMID 17157876DOI 10.1016/J.JMB.2006.11.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1itq DPEP1 human renal dipeptidase 2.3Å AUTH Y.NITANAI,Y.SATOW,H.ADACHI,M.TSUJIMOTOTITL CRYSTAL STRUCTURE OF HUMAN RENAL DIPEPTIDASE INVOLVED INTITL 2 BETA-LACTAM HYDROLYSISREF J.MOL.BIOL. V. 321 177 2002REFN ISSN 0022-2836PMID 12144777DOI 10.1016/S0022-2836(02)00632-0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants