2E0M.B | RNASE1

General Structure Information

PDB ID	2e0m
HGNC Gene Label(s)	RNASE1
Structure Name	mutant human ribonuclease 1 (t24l, q28l, r31l, r32l)
Resolution	1.7Å
Reference	AUTH H.YAMADA,T.TAMADA,M.KOSAKA,K.MIYATA,S.FUJIKI,M.TANO,AUTH 2 M.MORIYA,M.YAMANISHI,E.HONJO,H.TADA,T.INO,H.YAMAGUCHI,AUTH 3 J.FUTAMI,M.SENO,T.NOMOTO,T.HIRATA,M.YOSHIMURA,R.KUROKITITL CRYSTAL LATTICE ENGINEERING, AN APPROACH TO ENGINEERTITL 2 PROTEIN CRYSTAL CONTACTS BY CREATING INTERMOLECULARTITL 3 SYMMETRY: CRYSTALLIZATION AND STRUCTURE DETERMINATION OF ATITL 4 MUTANT HUMAN RNASE 1 WITH A HYDROPHOBIC INTERFACE OFTITL 5 LEUCINESREF PROTEIN SCI. V. 16 1389 2007REFN ISSN 0961-8368PMID 17586772DOI 10.1110/PS.072851407

Variant Set Distributions

ExAC Variants

Number Of Residues	128
Number Of SNVs	38
Number Of Permutations	10547
Optimal Distance Threshold	11.0
K Statistic	0.125
p-value	0.015

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
14:21270143		K>E	B:1	(-4.27, -70.27, -44.59)
14:21270134		R>W	B:4	(-8.54, -80.86, -50.34)
14:21270116		R>W	B:10	(-0.54, -74.75, -55.33)
14:21270109		H>R	B:12	(-2.48, -80.35, -60.00)
14:21270107	rs144718326	M>V	B:13	(-4.82, -76.01, -62.99)
14:21270103		D>A	B:14	(-1.27, -74.24, -66.45)
14:21270097		D>G	B:16	(-3.52, -69.48, -69.13)
14:21270094	rs576067562	S>N	B:17	(-0.09, -72.44, -70.67)
14:21270095	rs370813266	S>G	B:17	(-0.09, -72.44, -70.67)
14:21270091		S>F	B:18	(1.38, -74.31, -74.05)
14:21270089	rs549691901	P>S	B:19	(0.07, -77.48, -74.63)
14:21270073	rs181082069	T>S	B:24	(13.06, -75.44, -68.74)
14:21270074		T>P	B:24	(13.06, -75.44, -68.74)
14:21270070		Y>F	B:25	(6.19, -76.38, -67.62)
14:21270052		R>K	B:31	(9.85, -72.62, -58.39)
14:21270049		R>H	B:32	(6.47, -70.38, -60.06)
14:21270050	rs367926098	R>C	B:32	(6.47, -70.38, -60.06)
14:21270046		R>Q	B:33	(2.12, -73.11, -59.23)
14:21270037	COSM3361096	T>I	B:36	(10.32, -76.62, -54.69)
14:21270028	rs1804215	R>Q	B:39	(8.57, -81.62, -49.55)
14:21270017		V>M	B:43	(5.63, -86.60, -59.13)
14:21269995		P>L	B:50	(-10.10, -74.70, -69.08)
14:21269996	rs527787691	P>T	B:50	(-10.10, -74.70, -69.08)
14:21269990	rs142457376	V>L	B:52	(-14.88, -75.04, -66.43)
14:21269977	rs137913839	N>I	B:56	(-17.30, -79.85, -65.57)
14:21269962		E>G	B:61	(-16.71, -92.06, -65.82)
14:21269958	rs370850841	K>N	B:62	(-18.00, -92.49, -60.12)
14:21269932		N>S	B:71	(-15.87, -89.70, -54.64)
14:21269926		Y>F	B:73	(-15.73, -88.31, -60.49)
14:21269915		S>P	B:77	(-11.81, -85.65, -72.83)
14:21269890		R>H	B:85	(8.40, -88.12, -63.04)
14:21269891		R>C	B:85	(8.40, -88.12, -63.04)
14:21269879	rs371385743	G>S	B:89	(20.26, -86.03, -59.05)
14:21269872		R>K	B:91	(19.86, -84.55, -53.91)
14:21269870	rs143064811	Y>H	B:92	(15.44, -79.03, -50.50)
14:21269867	rs376304915	P>T	B:93	(17.54, -77.21, -52.52)
14:21269851		R>Q	B:98	(13.56, -85.86, -66.46)
14:21269852	rs145424082	R>W	B:98	(13.56, -85.86, -66.46)
14:21269848		T>I	B:99	(9.09, -82.08, -68.98)
14:21269849	rs555113365	T>A	B:99	(9.09, -82.08, -68.98)
14:21269843	rs372510186	P>S	B:101	(4.43, -83.52, -72.77)
14:21269838	rs11545379	K>N	B:102	(1.15, -86.76, -71.49)
14:21269824	rs150479420	I>T	B:107	(-8.66, -89.68, -62.76)
14:21269825		I>V	B:107	(-8.66, -89.68, -62.76)
14:21269810		G>R	B:112	(-18.19, -80.45, -51.77)
14:21269769	rs147875905	E>D	B:125	(-4.08, -93.12, -73.75)