General Structure Information
| PDB ID | 4j1y |
| HGNC Gene Label(s) | C1S |
| Structure Name | the x-ray crystal structure of human complement protease c1s zymogen |
| Resolution | 2.66Å |
| Reference | AUTH A.J.PERRY,L.C.WIJEYEWICKREMA,P.G.WILMANN,M.J.GUNZBURG,AUTH 2 L.DANDREA,J.A.IRVING,S.S.PANG,R.C.DUNCAN,J.A.WILCE,AUTH 3 J.C.WHISSTOCK,R.N.PIKETITL A MOLECULAR SWITCH GOVERNS THE INTERACTION BETWEEN THE HUMANTITL 2 COMPLEMENT PROTEASE C1S AND ITS SUBSTRATE, COMPLEMENT C4.REF J.BIOL.CHEM. V. 288 15821 2013REFN ISSN 0021-9258PMID 23592783DOI 10.1074/JBC.M113.464545 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 378 |
| Number Of SNVs | 89 |
| Number Of Permutations | 77285 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.187 |
| p-value | 0.11 |
COSMIC
| Number Of Residues | 378 |
| Number Of SNVs | 7 |
| Number Of Permutations | 8480 |
| Optimal Distance Threshold | 36.0 |
| K Statistic | 0.286 |
| p-value | 0.158 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 89 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 54.0 |
| K Statistic | -0.326 |
| p-value | 0.094 |