General Structure Information
| PDB ID | 1gmy |
| HGNC Gene Label(s) | CTSB |
| Structure Name | cathepsin b complexed with dipeptidyl nitrile inhibitor |
| Resolution | 1.9Å |
| Reference | AUTH P.D.GREENSPAN,K.L.CLARK,R.A.TOMMASI,S.D.COWEN,AUTH 2 L.W.MCQUIRE,D.L.FARLEY,J.H.VAN DUZER,R.L.GOLDBERG,AUTH 3 H.ZHOU,Z.DU,J.J.FITT,D.E.COPPA,Z.FANG,W.MACCHIA,AUTH 4 L.ZHU,M.P.CAPPARELLI,R.GOLDSTEIN,A.M.WIGG,AUTH 5 J.R.DOUGHTY,R.S BOHACEK,A.K.KNAPTITL IDENTIFICATION OF DIPEPTIDYL NITRILES AS POTENTTITL 2 AND SELECTIVE INHIBITORS OF CATHEPSIN B THROUGHTITL 3 STRUCTURE-BASED DRUG DESIGNREF J.MED.CHEM. V. 44 4524 2001REFN ISSN 0022-2623PMID 11741472DOI 10.1021/JM010206Q |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 253 |
| Number Of SNVs | 100 |
| Number Of Permutations | 30049 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.111 |
| p-value | 0.025 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 8:11708454 | S>N | A:4 | (9.11, 50.13, 24.73) | |
| 8:11708430 | rs11548596 | P>L | A:12 | (2.33, 43.80, 37.50) |
| 8:11708416 | rs369986037 | I>V | A:17 | (10.25, 41.49, 37.62) |
| 8:11708413 | K>E | A:18 | (9.56, 45.01, 40.65) | |
| 8:11708405 | rs144771892 | I>M | A:20 | (17.75, 44.42, 42.97) |
| 8:11708398 | Q>E | A:23 | (26.90, 39.09, 43.98) | |
| 8:11708386 | G>C | A:27 | (31.21, 35.55, 41.74) | |
| 8:11708375 | W>C | A:30 | (27.03, 31.52, 38.06) | |
| 8:11706672 | rs149411885 | A>V | A:31 | (23.62, 32.65, 39.44) |
| 8:11706650 | I>M | A:38 | (14.29, 31.31, 36.80) | |
| 8:11706642 | R>Q | A:41 | (10.93, 33.21, 32.33) | |
| 8:11706643 | rs536248833 | R>W | A:41 | (10.93, 33.21, 32.33) |
| 8:11706638 | I>M | A:42 | (8.14, 30.65, 37.88) | |
| 8:11706640 | I>V | A:42 | (8.14, 30.65, 37.88) | |
| 8:11706627 | T>I | A:46 | (1.93, 30.82, 36.95) | |
| 8:11706624 | N>S | A:47 | (-0.73, 33.74, 35.28) | |
| 8:11706619 | H>N | A:49 | (-1.60, 31.69, 40.12) | |
| 8:11706613 | S>G | A:51 | (5.79, 34.10, 43.44) | |
| 8:11706604 | V>M | A:54 | (14.83, 31.20, 42.89) | |
| 8:11706600 | rs367716612 | S>L | A:55 | (18.11, 29.89, 45.44) |
| 8:11706597 | A>V | A:56 | (21.28, 31.55, 44.64) | |
| 8:11706594 | E>G | A:57 | (23.06, 29.46, 48.32) | |
| 8:11706568 | M>V | A:66 | (28.93, 21.42, 34.94) | |
| 8:11706558 | D>V | A:69 | (34.84, 27.76, 39.60) | |
| 8:11706559 | D>Y | A:69 | (34.84, 27.76, 39.60) | |
| 8:11705645 | P>S | A:76 | (25.50, 31.25, 32.29) | |
| 8:11705641 | A>V | A:77 | (24.44, 27.79, 30.37) | |
| 8:11705636 | A>T | A:79 | (22.59, 27.46, 35.15) | |
| 8:11705626 | F>S | A:82 | (21.26, 22.65, 38.31) | |
| 8:11705622 | W>C | A:83 | (15.31, 25.82, 35.69) | |
| 8:11705612 | G>R | A:87 | (16.65, 22.25, 40.14) | |
| 8:11705594 | L>F | A:93 | (17.59, 38.30, 50.40) | |
| 8:11705588 | rs543876755 | E>K | A:95 | (20.13, 37.55, 57.70) |
| 8:11705581 | H>R | A:97 | (15.04, 33.70, 57.94) | |
| 8:11705582 | rs573635072 | H>Y | A:97 | (15.04, 33.70, 57.94) |
| 8:11705322 | P>L | A:102 | (18.40, 31.51, 52.26) | |
| 8:11705317 | S>A | A:104 | (25.08, 32.69, 52.78) | |
| 8:11705296 | H>Y | A:111 | (32.24, 49.46, 42.92) | |
| 8:11705290 | rs200297566 | N>H | A:113 | (30.30, 55.03, 49.71) |
| 8:11705287 | rs371843229 | G>S | A:114 | (27.83, 52.81, 52.88) |
| 8:11705280 | R>Q | A:116 | (26.04, 47.69, 52.68) | |
| 8:11705275 | P>A | A:118 | (33.31, 47.08, 52.05) | |
| 8:11705268 | rs147640153 | T>M | A:120 | (35.72, 41.64, 49.55) |
| 8:11705266 | rs145271056 | G>W | A:121 | (37.02, 39.21, 47.42) |
| 8:11705263 | rs529418411 | E>Q | A:122 | (36.00, 36.23, 44.20) |
| 8:11705260 | G>R | A:123 | (35.29, 33.87, 48.12) | |
| 8:11705255 | rs139775721 | D>E | A:124 | (35.24, 30.64, 50.14) |
| 8:11705257 | D>H | A:124 | (35.24, 30.64, 50.14) | |
| 8:11705247 | rs147236232 | K>T | A:127 | (29.58, 23.27, 51.46) |
| 8:11705241 | S>N | A:129 | (22.86, 22.16, 51.92) | |
| 8:11705242 | rs190293135 | S>G | A:129 | (22.86, 22.16, 51.92) |
| 8:11705232 | C>Y | A:132 | (15.44, 23.56, 54.02) | |
| 8:11705214 | P>L | A:138 | (8.23, 22.26, 51.31) | |
| 8:11705204 | K>N | A:141 | (13.03, 15.99, 46.84) | |
| 8:11705201 | rs200941300 | Q>H | A:142 | (8.80, 18.40, 48.45) |
| 8:11705203 | Q>E | A:142 | (8.80, 18.40, 48.45) | |
| 8:11705199 | D>G | A:143 | (10.89, 23.79, 47.07) | |
| 8:11705197 | K>E | A:144 | (13.92, 21.57, 43.57) | |
| 8:11705192 | H>Q | A:145 | (10.75, 25.30, 41.69) | |
| 8:11705194 | H>D | A:145 | (10.75, 25.30, 41.69) | |
| 8:11705188 | G>R | A:147 | (12.90, 23.22, 33.90) | |
| 8:11704674 | Y>C | A:148 | (10.13, 22.12, 28.96) | |
| 8:11704675 | rs141517224 | Y>H | A:148 | (10.13, 22.12, 28.96) |
| 8:11704671 | N>S | A:149 | (13.47, 24.58, 28.14) | |
| 8:11704663 | S>G | A:152 | (20.63, 30.08, 23.39) | |
| 8:11704656 | S>C | A:154 | (20.40, 34.96, 18.86) | |
| 8:11704654 | N>H | A:155 | (23.93, 38.08, 18.45) | |
| 8:11704644 | K>R | A:158 | (14.75, 42.44, 16.86) | |
| 8:11704645 | rs138489258 | K>E | A:158 | (14.75, 42.44, 16.86) |
| 8:11704639 | rs367715642 | I>V | A:160 | (17.03, 39.32, 22.63) |
| 8:11704635 | M>T | A:161 | (13.41, 42.47, 21.67) | |
| 8:11704632 | rs375382119 | A>V | A:162 | (11.04, 38.37, 21.49) |
| 8:11704625 | I>M | A:164 | (12.18, 39.67, 26.90) | |
| 8:11704624 | Y>D | A:165 | (6.42, 40.85, 24.09) | |
| 8:11704619 | rs145214017 | K>N | A:166 | (6.18, 36.28, 23.81) |
| 8:11704620 | K>R | A:166 | (6.18, 36.28, 23.81) | |
| 8:11704618 | rs529427270 | N>H | A:167 | (9.00, 33.95, 27.31) |
| 8:11704614 | rs201719073 | G>D | A:168 | (10.79, 37.07, 29.78) |
| 8:11704615 | G>S | A:168 | (10.79, 37.07, 29.78) | |
| 8:11704606 | E>K | A:171 | (21.23, 35.17, 32.19) | |
| 8:11704599 | COSM1095300 | A>G | A:173 | (26.57, 38.88, 29.45) |
| 8:11704600 | A>T | A:173 | (26.57, 38.88, 29.45) | |
| 8:11704593 | rs200664537 | S>C | A:175 | (32.37, 43.27, 29.05) |
| 8:11704587 | Y>C | A:177 | (35.39, 47.53, 29.80) | |
| 8:11704573 | rs375885162 | L>F | A:182 | (31.02, 54.99, 39.09) |
| 8:11704566 | rs375938153 | K>T | A:184 | (24.72, 56.54, 39.24) |
| 8:11703295 | V>A | A:187 | (22.44, 54.85, 27.98) | |
| 8:11703296 | V>L | A:187 | (22.44, 54.85, 27.98) | |
| 8:11703284 | V>I | A:191 | (34.41, 55.19, 26.32) | |
| 8:11703280 | rs375073968 | T>S | A:192 | (37.38, 54.19, 28.89) |
| 8:11703270 | M>I | A:195 | (38.38, 44.05, 31.00) | |
| 8:11703271 | M>R | A:195 | (38.38, 44.05, 31.00) | |
| 8:11703267 | rs199904756 | M>I | A:196 | (37.44, 44.76, 35.37) |
| 8:11703251 | rs145252189 | R>C | A:202 | (17.15, 40.70, 35.49) |
| 8:11703241 | rs73209021 | G>A | A:205 | (14.22, 45.38, 28.59) |
| 8:11703235 | G>V | A:207 | (14.56, 51.38, 24.68) | |
| 8:11703236 | G>R | A:207 | (14.56, 51.38, 24.68) | |
| 8:11703233 | V>M | A:208 | (14.72, 54.84, 23.05) | |
| 8:11703229 | E>A | A:209 | (17.02, 57.53, 27.09) | |
| 8:11703223 | G>D | A:211 | (17.89, 57.97, 20.56) | |
| 8:11703224 | G>S | A:211 | (17.89, 57.97, 20.56) | |
| 8:11703218 | P>S | A:213 | (19.27, 52.48, 21.56) | |
| 8:11703208 | L>R | A:216 | (16.12, 47.47, 31.52) | |
| 8:11703206 | rs200851570 | V>I | A:217 | (19.84, 45.70, 33.04) |
| 8:11703196 | S>F | A:220 | (23.93, 41.83, 41.47) | |
| 8:11703187 | T>S | A:223 | (19.58, 49.19, 45.81) | |
| 8:11703172 | N>S | A:228 | (17.61, 52.21, 42.14) | |
| 8:11702729 | F>V | A:230 | (17.62, 48.33, 37.90) | |
| 8:11702710 | G>E | A:236 | (22.36, 46.85, 18.60) | |
| 8:11702705 | rs79487342 | D>N | A:238 | (27.09, 42.98, 20.82) |
| 8:11702699 | C>R | A:240 | (30.13, 44.93, 25.81) | |
| 8:11702690 | COSM177681 | E>K | A:243 | (23.27, 41.65, 21.95) |
| 8:11702681 | V>L | A:246 | (21.29, 35.57, 25.79) | |
| 8:11702678 | V>L | A:247 | (20.59, 32.44, 28.47) | |
| 8:11702666 | P>S | A:251 | (9.00, 27.32, 33.17) | |
| 8:11702663 | rs148519031 | R>C | A:252 | (8.66, 20.57, 34.61) |
| 8:11702659 | rs144732218 | T>I | A:253 | (4.40, 23.22, 35.92) |