Assessment of Structural Intolerance and Durability
General Structure Information 1aye CPA2 human procarboxypeptidase a2 1.8Å AUTH I.GARCIA-SAEZ,D.REVERTER,J.VENDRELL,F.X.AVILES,AUTH 2 M.COLLTITL THE THREE-DIMENSIONAL STRUCTURE OF HUMANTITL 2 PROCARBOXYPEPTIDASE A2. DECIPHERING THE BASIS OFTITL 3 THE INHIBITION, ACTIVATION AND INTRINSIC ACTIVITYTITL 4 OF THE ZYMOGEN.REF EMBO J. V. 16 6906 1997REFN ISSN 0261-4189PMID 9384570DOI 10.1093/EMBOJ/16.23.6906 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2xcv NT5C2 crystal structure of the d52n variant of cytosolic 5- nucleotidase ii in complex with inosine monophosphate and 2,3-bisphosphoglycerate 2.3Å AUTH K.WALLDEN,P.NORDLUNDTITL STRUCTURAL BASIS FOR THE ALLOSTERIC REGULATION ANDTITL 2 SUBSTRATE RECOGNITION OF HUMAN CYTOSOLIC 5-NUCLEOTIDASE IIREF J.MOL.BIOL. V. 408 684 2011REFN ISSN 0022-2836PMID 21396942DOI 10.1016/J.JMB.2011.02.059 Variant Set Distributions Ripley’s K […]
General Structure Information 3hlk ACOT2 crystal structure of human mitochondrial acyl-coa thioesterase (acot2) 2.1Å AUTH C.R.MANDEL,B.TWEEL,L.TONGTITL CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL ACYL-COATITL 2 THIOESTERASE (ACOT2)REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 385 630 2009REFN ISSN 0006-291XPMID 19497300DOI 10.1016/J.BBRC.2009.05.122 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3hhd FASN structure of the human fatty acid synthase ks-mat didomain as a framework for inhibitor design. 2.15Å AUTH G.PAPPENBERGER,J.BENZ,B.GSELL,M.HENNIG,A.RUF,AUTH 2 M.STIHLE,R.THOMA,M.G.RUDOLPHTITL STRUCTURE OF THE HUMAN FATTY ACID SYNTHASE KS-MATTITL 2 DIDOMAIN AS A FRAMEWORK FOR INHIBITOR DESIGN.REF J.MOL.BIOL. V. 397 508 2010REFN ISSN 0022-2836PMID 20132826DOI 10.1016/J.JMB.2010.01.066 Variant Set Distributions Ripley’s K […]
General Structure Information 1cjy PLA2G4A human cytosolic phospholipase a2 2.5Å AUTH A.DESSEN,J.TANG,H.SCHMIDT,M.STAHL,J.D.CLARK,AUTH 2 J.SEEHRA,W.S.SOMERSTITL CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC PHOSPHOLIPASETITL 2 A2 REVEALS A NOVEL TOPOLOGY AND CATALYTICTITL 3 MECHANISM.REF CELL(CAMBRIDGE,MASS.) V. 97 349 1999REFN ISSN 0092-8674PMID 10319815DOI 10.1016/S0092-8674(00)80744-8 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4kkd MASP1 the x-ray crystal structure of mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the 3mc syndrome 2.6Å AUTH T.YONGQING,P.G.WILMANN,S.B.REEVE,T.H.COETZER,A.I.SMITH,AUTH 2 J.C.WHISSTOCK,R.N.PIKE,L.C.WIJEYEWICKREMATITL THE X-RAY CRYSTAL STRUCTURE OF MANNOSE-BINDINGTITL 2 LECTIN-ASSOCIATED SERINE PROTEINASE-3 REVEALS THE STRUCTURALTITL 3 BASIS FOR ENZYME INACTIVITY ASSOCIATED WITH THE CARNEVALE,TITL 4 MINGARELLI, […]
General Structure Information 3t1i MRE11A crystal structure of human mre11: understanding tumorigenic mutations 3.0Å AUTH Y.B.PARK,J.CHAE,Y.KIM,Y.CHOTITL CRYSTAL STRUCTURE OF HUMAN MRE11: UNDERSTANDING TUMORIGENICTITL 2 MUTATIONSREF STRUCTURE V. 19 1591 2011REFN ISSN 0969-2126PMID 22078559DOI 10.1016/J.STR.2011.09.010 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1mzd GZMK crystal structure of human pro-granzyme k 2.9Å AUTH C.HINK-SCHAUER,E.ESTEBANEZ-PERPINA,E.WILHARM,AUTH 2 P.FUENTES-PRIOR,W.KLINKERT,W.BODE,D.E.JENNETITL THE 2.2-A CRYSTAL STRUCTURE OF HUMAN PRO-GRANZYMETITL 2 K REVEALS A RIGID ZYMOGEN WITH UNUSUAL FEATURESREF J.BIOL.CHEM. V. 277 50923 2002REFN ISSN 0021-9258PMID 12384499DOI 10.1074/JBC.M207962200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2qxi KLK7 high resolution structure of human kallikrein 7 in complex with suc-ala-ala-pro-phe-chloromethylketone 1.0Å AUTH M.DEBELA,P.HESS,V.MAGDOLEN,N.M.SCHECHTER,T.STEINER,AUTH 2 R.HUBER,W.BODE,P.GOETTIGTITL CHYMOTRYPTIC SPECIFICITY DETERMINANTS IN THE 1.0 ATITL 2 STRUCTURE OF THE ZINC-INHIBITED HUMAN TISSUETITL 3 KALLIKREIN 7.REF PROC.NATL.ACAD.SCI.USA V. 104 16086 2007REFN ISSN 0027-8424PMID 17909180DOI 10.1073/PNAS.0707811104 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 1ne7 GNPDA1 human glucosamine-6-phosphate deaminase isomerase at 1.75 a resolution complexed with n-acetyl-glucosamine-6-phosphate and 2-deoxy-2-amino-glucitol-6-phosphate 1.75Å AUTH R.ARREOLA,B.VALDERRAMA,M.L.MORANTE,E.HORJALESTITL TWO MAMMALIAN GLUCOSAMINE-6-PHOSPHATE DEAMINASES:TITL 2 A STRUCTURAL AND GENETIC STUDY.REF FEBS LETT. V. 551 63 2003REFN ISSN 0014-5793PMID 12965206DOI 10.1016/S0014-5793(03)00896-2 Variant Set Distributions Mapped Variants