General Structure Information
| PDB ID | 2xcv |
| HGNC Gene Label(s) | NT5C2 |
| Structure Name | crystal structure of the d52n variant of cytosolic 5- nucleotidase ii in complex with inosine monophosphate and 2,3-bisphosphoglycerate |
| Resolution | 2.3Å |
| Reference | AUTH K.WALLDEN,P.NORDLUNDTITL STRUCTURAL BASIS FOR THE ALLOSTERIC REGULATION ANDTITL 2 SUBSTRATE RECOGNITION OF HUMAN CYTOSOLIC 5-NUCLEOTIDASE IIREF J.MOL.BIOL. V. 408 684 2011REFN ISSN 0022-2836PMID 21396942DOI 10.1016/J.JMB.2011.02.059 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 462 |
| Number Of SNVs | 62 |
| Number Of Permutations | 12672 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.039 |
| p-value | 0.268 |
COSMIC
| Number Of Residues | 462 |
| Number Of SNVs | 11 |
| Number Of Permutations | 2163 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.091 |
| p-value | 0.573 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 62 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.042 |
| p-value | 0.952 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
