Assessment of Structural Intolerance and Durability
General Structure Information 2zks GZMM structural insights into the proteolytic machinery of apoptosis- inducing granzyme m 2.7Å AUTH L.WU,L.WANG,G.HUA,K.LIU,X.YANG,Y.ZHAI,M.BARTLAM,F.SUN,Z.FANTITL STRUCTURAL BASIS FOR PROTEOLYTIC SPECIFICITY OF THE HUMANTITL 2 APOPTOSIS-INDUCING GRANZYME MREF J.IMMUNOL. V. 183 421 2009REFN ISSN 0022-1767PMID 19542453DOI 10.4049/JIMMUNOL.0803088 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3jwq PDE6C crystal structure of chimeric pde5/pde6 catalytic domain complexed with sildenafil 2.87Å AUTH B.BARREN,L.GAKHAR,H.MURADOV,K.K.BOYD,S.RAMASWAMY,AUTH 2 N.O.ARTEMYEVTITL STRUCTURAL BASIS OF PHOSPHODIESTERASE 6 INHIBITION BY THETITL 2 C-TERMINAL REGION OF THE GAMMA-SUBUNITREF EMBO J. V. 28 3613 2009REFN ISSN 0261-4189PMID 19798052DOI 10.1038/EMBOJ.2009.284 Variant Set Distributions Mapped Variants
General Structure Information 2o36 THOP1 crystal structure of engineered thimet oligopeptidase with neurolysin specificity in neurotensin cleavage site 1.95Å AUTH E.J.LIM,S.SAMPATH,J.COLL-RODRIGUEZ,J.SCHMIDT,K.RAY,AUTH 2 D.W.RODGERSTITL SWAPPING THE SUBSTRATE SPECIFICITIES OF THETITL 2 NEUROPEPTIDASES NEUROLYSIN AND THIMETTITL 3 OLIGOPEPTIDASE.REF J.BIOL.CHEM. V. 282 9722 2007REFN ISSN 0021-9258PMID 17251185DOI 10.1074/JBC.M609897200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2kyt PLA2G16 solution struture of the h-rev107 n-terminal domain -1.0Å AUTH X.REN,J.LIN,C.JIN,B.XIATITL SOLUTION STRUCTURE OF THE N-TERMINAL CATALYTIC DOMAIN OFTITL 2 HUMAN H-REV107–A NOVEL CIRCULAR PERMUTATED NLPC/P60 DOMAINREF FEBS LETT. V. 584 4222 2010REFN ISSN 0014-5793PMID 20837014DOI 10.1016/J.FEBSLET.2010.09.015 Variant Set Distributions Mapped Variants
General Structure Information 4fit FHIT fhit-apo 2.5Å AUTH C.D.LIMA,M.G.KLEIN,W.A.HENDRICKSONTITL STRUCTURE-BASED ANALYSIS OF CATALYSIS ANDTITL 2 SUBSTRATE DEFINITION IN THE HIT PROTEIN FAMILY.REF SCIENCE V. 278 286 1997REFN ISSN 0036-8075PMID 9323207DOI 10.1126/SCIENCE.278.5336.286 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ea2 METAP2 h-metap2 complexed with a773812 2.5Å AUTH G.T.WANG,R.A.MANTEI,M.KAWAI,J.S.TEDROW,D.M.BARNES,AUTH 2 J.WANG,Q.ZHANG,P.LOU,L.A.GARCIA,J.BOUSKA,M.YATES,AUTH 3 C.PARK,R.A.JUDGE,R.LESNIEWSKI,G.S.SHEPPARD,R.L.BELLTITL LEAD OPTIMIZATION OF METHIONINE AMINOPEPTIDASE-2TITL 2 (METAP2) INHIBITORS CONTAINING SULFONAMIDES OFTITL 3 5,6-DISUBSTITUTED ANTHRANILIC ACIDSREF BIOORG.MED.CHEM.LETT. V. 17 2817 2007REFN ISSN 0960-894XPMID 17350258DOI 10.1016/J.BMCL.2007.02.062 Variant Set Distributions Mapped Variants
General Structure Information 3ddu PREP prolyl oligopeptidase with gsk552 1.56Å AUTH C.D.HAFFNER,C.J.DIAZ,A.B.MILLER,R.A.REID,K.P.MADAUSS,AUTH 2 A.HASSELL,M.H.HANLON,D.J.PORTER,J.D.BECHERER,L.H.CARTERTITL PYRROLIDINYL PYRIDONE AND PYRAZINONE ANALOGUES AS POTENTTITL 2 INHIBITORS OF PROLYL OLIGOPEPTIDASE (POP)REF BIOORG.MED.CHEM.LETT. V. 18 4360 2008REFN ISSN 0960-894XPMID 18606544DOI 10.1016/J.BMCL.2008.06.067 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2kr6 PSEN1 solution structure of presenilin-1 ctf subunit -1.0Å AUTH V.DOETSCHTITL SOLUTION STRUCTURE OF PRESENILIN-1 CTF SUBUNITREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3h95 NUDT6 crystal structure of the nudix domain of nudt6 1.7Å AUTH L.TRESAUGUES,M.MOCHE,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTYENOVA,A.KOTZCH,T.K.NIELSEN,T.NYMAN,C.PERSSON,AUTH 5 J.SAGEMARK,H.SCHUELER,P.SCHUTZ,M.I.SIPONEN,L.SVENSSON,AUTH 6 A.G.THORSELL,S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WISNIEWSKA,AUTH 7 P.NORDLUNDTITL CRYSTAL STRUCTURE OF THE NUDIX DOMAIN OF NUDT6REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3gro PPT1 human palmitoyl-protein thioesterase 1 2.53Å AUTH E.DOBROVETSKY,A.SEITOVA,Y.TONG,W.TEMPEL,A.DONG,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,AUTH 3 A.BOCHKAREV,D.COSSAR,H.PARKTITL HUMAN PALMITOYL-PROTEIN THIOESTERASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants