Assessment of Structural Intolerance and Durability
General Structure Information 2zu6 EIF4A1 crystal structure of the eif4a-pdcd4 complex 2.8Å AUTH J.H.CHANG,Y.H.CHO,S.Y.SOHN,J.M.CHOI,A.KIM,Y.C.KIM,AUTH 2 S.K.JANG,Y.CHOTITL CRYSTAL STRUCTURE OF THE EIF4A-PDCD4 COMPLEXREF PROC.NATL.ACAD.SCI.USA V. 106 3148 2009REFN ISSN 0027-8424PMID 19204291DOI 10.1073/PNAS.0808275106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3dpr VLDLR human rhinovirus 2 bound to a concatamer of the vldl receptor module v3 3.5Å AUTH J.QUEROL-AUDI,T.KONECSNI,J.POUS,O.CARUGO,I.FITA,N.VERDAGUER,AUTH 2 D.BLAASTITL MINOR GROUP HUMAN RHINOVIRUS-RECEPTOR INTERACTIONS: GEOMETRYTITL 2 OF MULTIMODULAR ATTACHMENT AND BASIS OF RECOGNITIONREF FEBS LETT. V. 583 235 2009REFN ISSN 0014-5793PMID 19073182DOI 10.1016/J.FEBSLET.2008.12.014 Variant Set Distributions Mapped Variants
General Structure Information 4j6s YWHAG 14-3-3gamma complexed with the n-terminal sequence of tyrosine hydroxylase (residues 1-43) 3.08Å AUTH A.A.SKJEVIK,M.MILENI,A.BAUMANN,O.HALSKAU,K.TEIGEN,AUTH 2 R.C.STEVENS,A.MARTINEZTITL THE N-TERMINAL SEQUENCE OF TYROSINE HYDROXYLASE IS ATITL 2 CONFORMATIONALLY VERSATILE MOTIF THAT BINDS 14-3-3 PROTEINSTITL 3 AND MEMBRANES.REF J.MOL.BIOL. V. 426 150 2014REFN ISSN 0022-2836PMID 24055376DOI 10.1016/J.JMB.2013.09.012 Variant Set Distributions Mapped Variants
General Structure Information 3v6m CASP6 inhibition of caspase-6 activity by single mutation outside the active site 2.69Å AUTH Q.CAO,X.J.WANG,C.W.LIU,D.F.LIU,L.F.LI,Y.Q.GAO,X.D.SUTITL INHIBITORY MECHANISM OF CASPASE-6 PHOSPHORYLATION REVEALEDTITL 2 BY CRYSTAL STRUCTURES, MOLECULAR DYNAMICS SIMULATIONS, ANDTITL 3 BIOCHEMICAL ASSAYSREF J.BIOL.CHEM. V. 287 15371 2012REFN ISSN 0021-9258PMID 22433863DOI 10.1074/JBC.M112.351213 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3lhm LYZ crystal structures of the apo-and holomutant human lysozymes with an introduced ca2+ binding site 1.8Å AUTH K.INAKA,R.KUROKI,M.KIKUCHI,M.MATSUSHIMATITL CRYSTAL STRUCTURES OF THE APO- AND HOLOMUTANTTITL 2 HUMAN LYSOZYMES WITH AN INTRODUCED CA2+ BINDINGTITL 3 SITE.REF J.BIOL.CHEM. V. 266 20666 1991REFN ISSN 0021-9258PMID 1939116 Variant Set Distributions Mapped Variants
General Structure Information 3n5u PPP1CA crystal structure of an rb c-terminal peptide bound to the catalytic subunit of pp1 3.2Å AUTH A.HIRSCHI,M.CECCHINI,R.C.STEINHARDT,M.R.SCHAMBER,F.A.DICK,AUTH 2 S.M.RUBINTITL AN OVERLAPPING KINASE AND PHOSPHATASE DOCKING SITE REGULATESTITL 2 ACTIVITY OF THE RETINOBLASTOMA PROTEIN.REF NAT.STRUCT.MOL.BIOL. V. 17 1051 2010REFN ISSN 1545-9993PMID 20694007DOI 10.1038/NSMB.1868 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2m2f ADAM17 the membran-proximal domain of adam17 -1.0Å AUTH S.DUSTERHOFT,S.JUNG,C.W.HUNG,A.THOLEY,F.D.SONNICHSEN,AUTH 2 J.GROTZINGER,I.LORENZENTITL MEMBRANE-PROXIMAL DOMAIN OF A DISINTEGRIN ANDTITL 2 METALLOPROTEASE-17 REPRESENTS THE PUTATIVE MOLECULAR SWITCHTITL 3 OF ITS SHEDDING ACTIVITY OPERATED BY PROTEIN-DISULFIDETITL 4 ISOMERASE.REF J.AM.CHEM.SOC. V. 135 5776 2013REFN ISSN 0002-7863PMID 23521534DOI 10.1021/JA400340U Variant Set Distributions Mapped Variants
General Structure Information 4ie2 ARG2 crystal structure of human arginase-2 complexed with inhibitor 1h 2.21Å AUTH A.GOLEBIOWSKI,R.PAUL BECKETT,M.VAN ZANDT,M.K.JI,AUTH 2 D.WHITEHOUSE,T.R.RYDER,E.JAGDMANN,M.ANDREOLI,A.MAZUR,AUTH 3 M.PADMANILAYAM,A.COUSIDO-SIAH,A.MITSCHLER,F.X.RUIZ,AUTH 4 A.PODJARNY,H.SCHROETERTITL 2-SUBSTITUTED-2-AMINO-6-BORONOHEXANOIC ACIDS AS ARGINASETITL 2 INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 23 2027 2013REFN ISSN 0960-894XPMID 23453840DOI 10.1016/J.BMCL.2013.02.024 Variant Set Distributions Mapped Variants
General Structure Information 1taz PDE1B catalytic domain of human phosphodiesterase 1b 1.77Å AUTH K.Y.J.ZHANG,G.L.CARD,Y.SUZUKI,D.R.ARTIS,D.FONG,S.GILLETTE,AUTH 2 D.HSIEH,J.NEIMAN,B.L.WEST,C.ZHANG,M.V.MILBURN,S.-H.KIM,AUTH 3 J.SCHLESSINGER,G.BOLLAGTITL A GLUTAMINE SWITCH MECHANISM FOR NUCLEOTIDE SELECTIVITY BYTITL 2 PHOSPHODIESTERASESREF MOL.CELL V. 15 279 2004REFN ISSN 1097-2765PMID 15260978DOI 10.1016/J.MOLCEL.2004.07.005 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1d5r PTEN crystal structure of the pten tumor suppressor 2.1Å AUTH J.O.LEE,H.YANG,M.M.GEORGESCU,A.DI CRISTOFANO,AUTH 2 T.MAEHAMA,Y.SHI,J.E.DIXON,P.PANDOLFI,N.P.PAVLETICHTITL CRYSTAL STRUCTURE OF THE PTEN TUMOR SUPPRESSOR:TITL 2 IMPLICATIONS FOR ITS PHOSPHOINOSITIDE PHOSPHATASETITL 3 ACTIVITY AND MEMBRANE ASSOCIATION.REF CELL(CAMBRIDGE,MASS.) V. 99 323 1999REFN ISSN 0092-8674PMID 10555148DOI 10.1016/S0092-8674(00)81663-3 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]