General Structure Information
| PDB ID | 3n5u |
| HGNC Gene Label(s) | PPP1CA |
| Structure Name | crystal structure of an rb c-terminal peptide bound to the catalytic subunit of pp1 |
| Resolution | 3.2Å |
| Reference | AUTH A.HIRSCHI,M.CECCHINI,R.C.STEINHARDT,M.R.SCHAMBER,F.A.DICK,AUTH 2 S.M.RUBINTITL AN OVERLAPPING KINASE AND PHOSPHATASE DOCKING SITE REGULATESTITL 2 ACTIVITY OF THE RETINOBLASTOMA PROTEIN.REF NAT.STRUCT.MOL.BIOL. V. 17 1051 2010REFN ISSN 1545-9993PMID 20694007DOI 10.1038/NSMB.1868 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 294 |
| Number Of SNVs | 35 |
| Number Of Permutations | 11395 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.185 |
| p-value | 0.236 |
COSMIC
| Number Of Residues | 294 |
| Number Of SNVs | 3 |
| Number Of Permutations | 46 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.333 |
| p-value | 0.61 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 35 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.815 |
| p-value | 0.082 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
