General Structure Information
| PDB ID | 3v6m |
| HGNC Gene Label(s) | CASP6 |
| Structure Name | inhibition of caspase-6 activity by single mutation outside the active site |
| Resolution | 2.69Å |
| Reference | AUTH Q.CAO,X.J.WANG,C.W.LIU,D.F.LIU,L.F.LI,Y.Q.GAO,X.D.SUTITL INHIBITORY MECHANISM OF CASPASE-6 PHOSPHORYLATION REVEALEDTITL 2 BY CRYSTAL STRUCTURES, MOLECULAR DYNAMICS SIMULATIONS, ANDTITL 3 BIOCHEMICAL ASSAYSREF J.BIOL.CHEM. V. 287 15371 2012REFN ISSN 0021-9258PMID 22433863DOI 10.1074/JBC.M112.351213 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 204 |
| Number Of SNVs | 47 |
| Number Of Permutations | 7507 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.048 |
| p-value | 0.013 |
COSMIC
| Number Of Residues | 204 |
| Number Of SNVs | 3 |
| Number Of Permutations | 156 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.333 |
| p-value | 0.403 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
