Assessment of Structural Intolerance and Durability
General Structure Information 1yx6 PSMD4 solution structure of s5a uim-2/ubiquitin complex -1.0Å AUTH Q.WANG,P.YOUNG,K.J.WALTERSTITL STRUCTURE OF S5A BOUND TO MONOUBIQUITIN PROVIDES ATITL 2 MODEL FOR POLYUBIQUITIN RECOGNITIONREF J.MOL.BIOL. V. 348 727 2005REFN ISSN 0022-2836PMID 15826667DOI 10.1016/J.JMB.2005.03.007 Variant Set Distributions Mapped Variants
General Structure Information 1dgn CARD18 solution structure of iceberg, an inhibitor of interleukin- 1beta generation -1.0Å AUTH E.W.HUMKE,S.K.SHRIVER,M.A.STAROVASNIK,AUTH 2 W.J.FAIRBROTHER,V.M.DIXITTITL ICEBERG: A NOVEL INHIBITOR OF INTERLEUKIN-1BETATITL 2 GENERATION.REF CELL(CAMBRIDGE,MASS.) V. 103 99 2000REFN ISSN 0092-8674PMID 11051551DOI 10.1016/S0092-8674(00)00108-2 Variant Set Distributions Mapped Variants
General Structure Information 3v3k CASP9 human caspase 9 in complex with bacterial effector protein 3.49Å AUTH M.MOERTL,K.MASKOS,H.STEUBERTITL HUMAN CASPASE 9 IN COMPLEX WITH BACTERIAL EFFECTOR PROTEINREF PLOS ONE 2013REFN ESSN 1932-6203 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2a8h ADAM17 crystal structure of catalytic domain of tace with thiomorpholine sulfonamide hydroxamate inhibitor 2.3Å AUTH J.I.LEVIN,J.M.CHEN,L.M.LAAKSO,M.DU,J.SCHMID,W.XU,AUTH 2 T.CUMMONS,J.XU,G.JIN,D.BARONE,J.S.SKOTNICKITITL ACETYLENIC TACE INHIBITORS. PART 3: THIOMORPHOLINETITL 2 SULFONAMIDE HYDROXAMATES.REF BIOORG.MED.CHEM.LETT. V. 16 1605 2006REFN ISSN 0960-894XPMID 16426848DOI 10.1016/J.BMCL.2005.12.020 Variant Set Distributions Mapped Variants
General Structure Information 1l8l PSPH molecular basis for the local confomational rearrangement of human phosphoserine phosphatase 2.51Å AUTH H.Y.KIM,Y.S.HEO,J.H.KIM,M.H.PARK,J.MOON,E.KIM,AUTH 2 D.KWON,J.YOON,D.SHIN,E.J.JEONG,S.Y.PARK,T.G.LEE,AUTH 3 Y.H.JEON,S.RO,J.M.CHO,K.Y.HWANGTITL MOLECULAR BASIS FOR THE LOCAL CONFORMATIONALTITL 2 REARRANGEMENT OF HUMAN PHOSPHOSERINE PHOSPHATASE.REF J.BIOL.CHEM. V. 277 46651 2002REFN ISSN 0021-9258PMID 12213811DOI 10.1074/JBC.M204866200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3ex7 MAGOH the crystal structure of ejc in its transition state 2.3Å AUTH K.H.NIELSEN,H.CHAMIEH,C.B.ANDERSEN,F.FREDSLUND,AUTH 2 K.HAMBORG,H.LE HIR,G.R.ANDERSENTITL MECHANISM OF ATP TURNOVER INHIBITION IN THE EJCREF RNA V. 15 67 2009REFN ISSN 1355-8382PMID 19033377DOI 10.1261/RNA.1283109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1zy7 ADARB1 crystal structure of the catalytic domain of an adenosine deaminase that acts on rna (hadar2) bound to inositol hexakisphosphate (ihp) 1.7Å AUTH M.R.MACBETH,H.L.SCHUBERT,A.P.VANDEMARK,A.T.LINGAM,AUTH 2 C.P.HILL,B.L.BASSTITL INOSITOL HEXAKISPHOSPHATE IS BOUND IN THE ADAR2TITL 2 CORE AND REQUIRED FOR RNA EDITING.REF SCIENCE V. 309 1534 2005REFN ISSN 0036-8075PMID 16141067DOI 10.1126/SCIENCE.1113150 Variant Set […]
General Structure Information 1wao PPP5C pp5 structure 2.9Å AUTH J.YANG,S.M.ROE,M.J.CLIFF,M.A.WILLIAMS,J.E.LADBURY,AUTH 2 P.T.COHEN,D.BARFORDTITL MOLECULAR BASIS FOR TPR DOMAIN-MEDIATED REGULATIONTITL 2 OF PROTEIN PHOSPHATASE 5REF EMBO J. V. 24 1 2005REFN ISSN 0261-4189PMID 15577939DOI 10.1038/SJ.EMBOJ.7600496 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3c7x MMP14 hemopexin-like domain of matrix metalloproteinase 14 1.7Å AUTH A.TOCHOWICZ,P.GOETTIG,R.EVANS,R.VISSE,Y.SHITOMI,R.PALMISANO,AUTH 2 N.ITO,K.RICHTER,K.MASKOS,D.FRANKE,D.SVERGUN,H.NAGASE,W.BODE,AUTH 3 Y.ITOHTITL THE DIMER INTERFACE OF THE MEMBRANE TYPE 1 MATRIXTITL 2 METALLOPROTEINASE HEMOPEXIN DOMAIN: CRYSTAL STRUCTURE ANDTITL 3 BIOLOGICAL FUNCTIONSREF J.BIOL.CHEM. V. 286 7587 2011REFN ISSN 0021-9258PMID 21193411DOI 10.1074/JBC.M110.178434 Variant Set Distributions Mapped Variants
General Structure Information 2grc SMARCA4 1.5 a structure of bromodomain from human brg1 protein, a central atpase of swi/snf remodeling complex 1.5Å AUTH M.SINGH,G.M.POPOWICZ,M.KRAJEWSKI,T.A.HOLAKTITL STRUCTURAL RAMIFICATION FOR ACETYL-LYSINETITL 2 RECOGNITION BY THE BROMODOMAIN OF HUMAN BRG1TITL 3 PROTEIN, A CENTRAL ATPASE OF THE SWI/SNFTITL 4 REMODELING COMPLEX.REF CHEMBIOCHEM V. 8 1308 2007REFN ISSN 1439-4227PMID 17582821DOI […]