General Structure Information
| PDB ID | 2a8h |
| HGNC Gene Label(s) | ADAM17 |
| Structure Name | crystal structure of catalytic domain of tace with thiomorpholine sulfonamide hydroxamate inhibitor |
| Resolution | 2.3Å |
| Reference | AUTH J.I.LEVIN,J.M.CHEN,L.M.LAAKSO,M.DU,J.SCHMID,W.XU,AUTH 2 T.CUMMONS,J.XU,G.JIN,D.BARONE,J.S.SKOTNICKITITL ACETYLENIC TACE INHIBITORS. PART 3: THIOMORPHOLINETITL 2 SULFONAMIDE HYDROXAMATES.REF BIOORG.MED.CHEM.LETT. V. 16 1605 2006REFN ISSN 0960-894XPMID 16426848DOI 10.1016/J.BMCL.2005.12.020 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 259 |
| Number Of SNVs | 44 |
| Number Of Permutations | 21699 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.223 |
| p-value | 0.039 |