General Structure Information
| PDB ID | 1d5r |
| HGNC Gene Label(s) | PTEN |
| Structure Name | crystal structure of the pten tumor suppressor |
| Resolution | 2.1Å |
| Reference | AUTH J.O.LEE,H.YANG,M.M.GEORGESCU,A.DI CRISTOFANO,AUTH 2 T.MAEHAMA,Y.SHI,J.E.DIXON,P.PANDOLFI,N.P.PAVLETICHTITL CRYSTAL STRUCTURE OF THE PTEN TUMOR SUPPRESSOR:TITL 2 IMPLICATIONS FOR ITS PHOSPHOINOSITIDE PHOSPHATASETITL 3 ACTIVITY AND MEMBRANE ASSOCIATION.REF CELL(CAMBRIDGE,MASS.) V. 99 323 1999REFN ISSN 0092-8674PMID 10555148DOI 10.1016/S0092-8674(00)81663-3 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 307 |
| Number Of SNVs | 21 |
| Number Of Permutations | 10731 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.105 |
| p-value | 0.176 |
ClinVar
| Number Of Residues | 307 |
| Number Of SNVs | 47 |
| Number Of Permutations | 25135 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.203 |
| p-value | 0.0 |
COSMIC
| Number Of Residues | 307 |
| Number Of SNVs | 107 |
| Number Of Permutations | 44245 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.079 |
| p-value | 0.0 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 21 |
| Number Of ClinVar SNVs | 41 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.206 |
| p-value | 0.0 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 21 |
| Number Of COSMIC SNVs | 60 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | 0.212 |
| p-value | 0.006 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 10:89685272 | F>C | A:56 | (37.70, 109.24, 25.68) | |
| 10:89690823 | D>G | A:77 | (52.04, 98.92, 17.77) | |
| 10:89690826 | T>N | A:78 | (51.46, 100.78, 22.45) | |
| 10:89690828 | rs202004587 COSM5040 CM022240 |
A>T | A:79 | (52.06, 104.29, 20.20) |
| 10:89692792 | COSM125653 COSM35759 CM033666 |
D>E | A:92 | (37.87, 84.00, 22.81) |
| 10:89692866 | rs551221430 COSM3724547 |
N>S | A:117 | (47.96, 108.22, 37.69) |
| 10:89692920 | rs370795352 COSM5243 COSM1349532 COSM5797 CM110158 CM064180 |
I>T | A:135 | (36.72, 94.19, 36.53) |
| 10:89692940 | COSM5122 | R>W | A:142 | (39.44, 98.34, 47.18) |
| 10:89692956 | COSM23661 COSM1349542 COSM1349541 |
K>R | A:147 | (29.14, 87.72, 48.40) |
| 10:89711878 | COSM23652 COSM5203 |
V>I | A:166 | (30.17, 86.97, 33.17) |
| 10:89711900 | rs121913294 | R>H | A:173 | (34.03, 77.86, 37.71) |
| 10:89711909 | Y>C | A:176 | (31.99, 82.32, 42.66) | |
| 10:89711920 | COSM1349564 | Y>H | A:180 | (37.94, 79.64, 48.88) |
| 10:89711995 | M>V | A:205 | (19.35, 64.02, 24.58) | |
| 10:89712007 | COSM308351 | G>R | A:209 | (18.41, 59.85, 23.05) |
| 10:89717634 | rs141373793 | L>P | A:220 | (47.48, 74.69, 30.19) |
| 10:89717658 | N>S | A:228 | (37.34, 55.74, 22.79) | |
| 10:89717673 | COSM1297486 | R>Q | A:233 | (30.40, 51.39, 33.38) |
| 10:89717760 | N>S | A:262 | (26.36, 58.47, 11.89) | |
| 10:89720653 | rs398123328 | D>E | A:268 | (28.37, 67.12, 17.24) |
| 10:89720867 | N>H | A:340 | (18.60, 66.49, 37.16) |
[+] ClinVar Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 10:89624281 | rs121909233 | D>N | A:19 | (27.14, 108.17, 23.04) |
| 10:89624296 | rs786201995 | D>N | A:24 | (32.32, 99.72, 22.84) |
| 10:89624297 | rs797044910 | D>G | A:24 | (32.32, 99.72, 22.84) |
| 10:89624305 | rs746128825 | Y>N | A:27 | (33.53, 105.49, 32.39) |
| 10:89653806 | rs121909225 | M>R | A:35 | (37.40, 99.12, 26.16) |
| 10:89653808 | rs786204854 | G>R | A:36 | (37.13, 97.56, 23.42) |
| 10:89653814 | rs587780004 | P>S | A:38 | (41.74, 99.30, 20.51) |
| 10:89653839 | rs786204915 | Y>C | A:46 | (38.14, 94.10, 15.67) |
| 10:89653841 | rs786204855 | R>G | A:47 | (32.38, 98.10, 14.98) |
| 10:89685286 | rs121909236 | H>D | A:61 | (41.08, 110.76, 31.39) |
| 10:89685287 | rs398123316 | H>L | A:61 | (41.08, 110.76, 31.39) |
| 10:89685298 | rs587780005 | Y>D | A:65 | (45.72, 107.08, 29.77) |
| 10:89685314 | rs121909226 | L>P | A:70 | (42.72, 90.91, 28.53) |
| 10:89690831 | rs786204925 | K>Q | A:80 | (48.61, 105.60, 18.52) |
| 10:89692793 | rs786204927 | H>D | A:93 | (34.77, 82.93, 24.32) |
| 10:89692794 | rs121909238 | H>R | A:93 | (34.77, 82.93, 24.32) |
| 10:89692800 | rs786204856 | P>L | A:95 | (39.08, 80.97, 31.63) |
| 10:89692802 | rs398123320 | P>S | A:96 | (41.69, 83.22, 33.38) |
| 10:89692817 | rs786204857 | I>F | A:101 | (43.40, 86.78, 39.07) |
| 10:89692836 | rs786204858 | D>G | A:107 | (48.72, 96.28, 38.55) |
| 10:89692847 | rs398123321 | W>R | A:111 | (47.69, 103.77, 37.52) |
| 10:89692851 | rs121909230 | L>P | A:112 | (43.51, 102.97, 40.85) |
| 10:89692854 | rs587781254 | S>I | A:113 | (46.62, 103.90, 44.66) |
| 10:89692878 | rs121909237 | A>G | A:121 | (41.28, 100.75, 30.46) |
| 10:89692883 | rs786204931 | H>Y | A:123 | (41.25, 95.75, 26.00) |
| 10:89692884 | rs121909222 | H>R | A:123 | (41.25, 95.75, 26.00) |
| 10:89692886 | rs121909223 | C>R | A:124 | (38.85, 92.57, 25.07) |
| 10:89692895 | rs587781255 | G>R | A:127 | (33.87, 93.73, 26.29) |
| 10:89692901 | rs786204929 | G>R | A:129 | (33.96, 88.36, 29.63) |
| 10:89692902 | rs121909218 | G>E | A:129 | (33.96, 88.36, 29.63) |
| 10:89692905 | rs121909229 | R>Q | A:130 | (38.37, 88.07, 27.32) |
| 10:89692907 | rs786204932 | T>S | A:131 | (36.81, 92.63, 30.88) |
| 10:89692908 | rs397514560 | T>I | A:131 | (36.81, 92.63, 30.88) |
| 10:89692919 | rs587782360 | I>V | A:135 | (36.72, 94.19, 36.53) |
| 10:89692922 | rs786201044 | C>R | A:136 | (34.74, 91.29, 39.22) |
| 10:89692923 | rs786204859 | C>Y | A:136 | (34.74, 91.29, 39.22) |
| 10:89692979 | rs398123325 | Y>N | A:155 | (30.61, 93.73, 34.02) |
| 10:89692991 | rs786202688 | R>G | A:159 | (29.63, 96.90, 29.33) |
| 10:89711876 | rs786204863 | G>V | A:165 | (28.15, 89.32, 31.06) |
| 10:89711882 | rs397514559 | T>N | A:167 | (27.60, 84.30, 30.73) |
| 10:89711892 | rs121909221 | S>R | A:170 | (34.22, 78.70, 33.24) |
| 10:89711894 | rs786204865 | Q>R | A:171 | (34.45, 83.26, 32.19) |
| 10:89711899 | rs121913293 | R>C | A:173 | (34.03, 77.86, 37.71) |
| 10:89711900 | rs121913294 | R>H | A:173 | (34.03, 77.86, 37.71) |
| 10:89711902 | rs587782316 | Y>N | A:174 | (38.56, 80.45, 37.31) |
| 10:89711909 | rs757498880 | Y>C | A:176 | (31.99, 82.32, 42.66) |
| 10:89711915 | rs786204866 | Y>C | A:178 | (40.58, 86.14, 44.03) |
| 10:89711927 | rs794729664 | L>S | A:182 | (40.07, 86.89, 49.23) |
| 10:89711980 | rs587782473 | F>V | A:200 | (27.90, 61.56, 31.93) |
| 10:89711981 | rs786204867 | F>S | A:200 | (27.90, 61.56, 31.93) |
| 10:89717624 | rs121909234 | V>I | A:217 | (41.94, 66.13, 28.80) |
| 10:89717676 | rs121909235 | R>Q | A:234 | (24.78, 52.85, 29.15) |
| 10:89717691 | rs786204871 | M>R | A:239 | (27.42, 57.26, 30.67) |
| 10:89717697 | rs121909240 | F>S | A:241 | (33.29, 58.54, 30.73) |
| 10:89717712 | rs587782350 | P>L | A:246 | (45.71, 57.15, 36.79) |
| 10:89717730 | rs121909239 | D>G | A:252 | (44.29, 75.55, 35.29) |
[+] COSMIC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 10:89624266 | COSM5101 | R>G | A:14 | (20.37, 101.88, 33.60) |
| 10:89624269 | COSM1159817 | R>G | A:15 | (26.43, 102.46, 31.67) |
| 10:89624271 | COSM5270 | R>S | A:15 | (26.43, 102.46, 31.67) |
| 10:89624288 | COSM86059 | F>S | A:21 | (33.12, 111.04, 21.73) |
| 10:89624295 | COSM5185 | L>F | A:23 | (33.41, 104.95, 21.56) |
| 10:89624296 | COSM5237 | D>Y | A:24 | (32.32, 99.72, 22.84) |
| 10:89624298 | COSM5198 | D>E | A:24 | (32.32, 99.72, 22.84) |
| 10:89624302 | COSM1561216 | T>A | A:26 | (31.44, 101.28, 30.03) |
| 10:89624303 | COSM1349469 | T>I | A:26 | (31.44, 101.28, 30.03) |
| 10:89624305 | COSM1561215 | Y>H | A:27 | (33.53, 105.49, 32.39) |
| 10:89653786 | COSM87307 | I>M | A:28 | (32.40, 99.80, 35.75) |
| 10:89653805 | COSM1666994 | M>L | A:35 | (37.40, 99.12, 26.16) |
| 10:89653807 | COSM1505981 | M>I | A:35 | (37.40, 99.12, 26.16) |
| 10:89653809 | COSM5137 | G>E | A:36 | (37.13, 97.56, 23.42) |
| 10:89653812 | COSM5116 | F>S | A:37 | (40.93, 95.81, 19.90) |
| 10:89653814 | COSM5142 | P>S | A:38 | (41.74, 99.30, 20.51) |
| 10:89653827 | COSM5269 | L>R | A:42 | (38.27, 98.59, 11.50) |
| 10:89653829 | COSM4894833 | E>K | A:43 | (37.70, 93.52, 10.03) |
| 10:89653833 | COSM5097 | G>D | A:44 | (34.04, 92.73, 12.21) |
| 10:89653836 | COSM1242727 | V>A | A:45 | (34.09, 92.06, 16.08) |
| 10:89653839 | COSM1675407 | Y>C | A:46 | (38.14, 94.10, 15.67) |
| 10:89653841 | COSM28887 | R>G | A:47 | (32.38, 98.10, 14.98) |
| 10:89653845 | COSM5238 | N>I | A:48 | (36.42, 100.92, 18.81) |
| 10:89653857 | COSM5115 | D>G | A:52 | (38.59, 108.04, 18.20) |
| 10:89653865 | COSM5129 | R>G | A:55 | (41.17, 111.67, 19.31) |
| 10:89685271 | COSM5257 | F>V | A:56 | (37.70, 109.24, 25.68) |
| 10:89685287 | COSM5042 | H>R | A:61 | (41.08, 110.76, 31.39) |
| 10:89685288 | COSM1600113 | H>Q | A:61 | (41.08, 110.76, 31.39) |
| 10:89685291 | COSM86050 | K>N | A:62 | (45.45, 115.44, 30.62) |
| 10:89685301 | COSM5048 | K>E | A:66 | (47.53, 101.60, 33.03) |
| 10:89685305 | COSM5251 | I>R | A:67 | (45.46, 100.54, 28.85) |
| 10:89685307 | COSM249839 | Y>N | A:68 | (45.30, 97.09, 32.40) |
| 10:89685308 | COSM43077 | Y>C | A:68 | (45.30, 97.09, 32.40) |
| 10:89685314 | COSM3397283 | L>H | A:70 | (42.72, 90.91, 28.53) |
| 10:89690820 | COSM1561213 | Y>C | A:76 | (47.35, 97.49, 20.59) |
| 10:89690828 | COSM5040 | A>T | A:79 | (52.06, 104.29, 20.20) |
| 10:89690835 | COSM5282 | F>C | A:81 | (47.26, 104.09, 23.58) |
| 10:89690838 | COSM5205 | N>T | A:82 | (50.70, 109.03, 26.41) |
| 10:89692772 | COSM1349494 | A>S | A:86 | (49.26, 96.05, 30.36) |
| 10:89692779 | COSM5240 | Y>S | A:88 | (47.72, 91.14, 32.78) |
| 10:89692785 | COSM5141 | F>S | A:90 | (42.45, 85.82, 29.05) |
| 10:89692790 | COSM23566 | D>H | A:92 | (37.87, 84.00, 22.81) |
| 10:89692791 | COSM5236 | D>V | A:92 | (37.87, 84.00, 22.81) |
| 10:89692792 | COSM35759 | D>E | A:92 | (37.87, 84.00, 22.81) |
| 10:89692793 | COSM5043 | H>Y | A:93 | (34.77, 82.93, 24.32) |
| 10:89692794 | COSM5060 | H>R | A:93 | (34.77, 82.93, 24.32) |
| 10:89692795 | COSM5186 | H>Q | A:93 | (34.77, 82.93, 24.32) |
| 10:89692797 | COSM1349500 | N>S | A:94 | (38.55, 80.67, 27.73) |
| 10:89692799 | COSM5136 | P>S | A:95 | (39.08, 80.97, 31.63) |
| 10:89692800 | COSM5105 | P>L | A:95 | (39.08, 80.97, 31.63) |
| 10:89692802 | COSM921085 | P>T | A:96 | (41.69, 83.22, 33.38) |
| 10:89692803 | COSM5265 | P>Q | A:96 | (41.69, 83.22, 33.38) |
| 10:89692818 | COSM5259 | I>N | A:101 | (43.40, 86.78, 39.07) |
| 10:89692829 | COSM5254 | C>G | A:105 | (44.27, 92.83, 41.38) |
| 10:89692830 | COSM6206 | C>S | A:105 | (44.27, 92.83, 41.38) |
| 10:89692833 | COSM1968231 | E>G | A:106 | (48.30, 93.19, 43.52) |
| 10:89692835 | COSM30611 | D>N | A:107 | (48.72, 96.28, 38.55) |
| 10:89692839 | COSM13135 | L>R | A:108 | (44.19, 97.90, 38.96) |
| 10:89692841 | COSM2155196 | D>N | A:109 | (45.08, 98.55, 43.92) |
| 10:89692845 | COSM1349509 | Q>R | A:110 | (49.77, 100.32, 42.79) |
| 10:89692847 | COSM5121 | W>R | A:111 | (47.69, 103.77, 37.52) |
| 10:89692850 | COSM1349510 | L>I | A:112 | (43.51, 102.97, 40.85) |
| 10:89692851 | COSM5106 | L>P | A:112 | (43.51, 102.97, 40.85) |
| 10:89692857 | COSM1349513 | E>G | A:114 | (46.51, 108.13, 43.05) |
| 10:89692869 | COSM3736941 | H>L | A:118 | (43.14, 108.88, 38.52) |
| 10:89692871 | COSM39406 | V>F | A:119 | (42.00, 105.98, 35.20) |
| 10:89692872 | COSM5215 | V>D | A:119 | (42.00, 105.98, 35.20) |
| 10:89692874 | COSM1577255 | A>T | A:120 | (41.47, 102.13, 34.04) |
| 10:89692878 | COSM5273 | A>E | A:121 | (41.28, 100.75, 30.46) |
| 10:89692881 | COSM5234 | I>S | A:122 | (40.11, 97.04, 31.18) |
| 10:89692883 | COSM5078 | H>Y | A:123 | (41.25, 95.75, 26.00) |
| 10:89692884 | COSM1349520 | H>R | A:123 | (41.25, 95.75, 26.00) |
| 10:89692886 | COSM5224 | C>S | A:124 | (38.85, 92.57, 25.07) |
| 10:89692887 | COSM5140 | C>Y | A:124 | (38.85, 92.57, 25.07) |
| 10:89692891 | COSM17566 | K>N | A:125 | (37.44, 90.80, 20.74) |
| 10:89692892 | COSM28889 | A>S | A:126 | (33.96, 93.21, 22.92) |
| 10:89692893 | COSM4391544 | A>G | A:126 | (33.96, 93.21, 22.92) |
| 10:89692895 | COSM249825 | G>R | A:127 | (33.87, 93.73, 26.29) |
| 10:89692898 | COSM685104 | K>Q | A:128 | (31.13, 89.96, 27.38) |
| 10:89692899 | COSM1349526 | K>R | A:128 | (31.13, 89.96, 27.38) |
| 10:89692900 | COSM242607 | K>N | A:128 | (31.13, 89.96, 27.38) |
| 10:89692902 | COSM5276 | G>V | A:129 | (33.96, 88.36, 29.63) |
| 10:89692905 | COSM5277 | R>P | A:130 | (38.37, 88.07, 27.32) |
| 10:89692908 | COSM5104 | T>I | A:131 | (36.81, 92.63, 30.88) |
| 10:89692910 | COSM1561209 | G>C | A:132 | (34.78, 90.79, 33.86) |
| 10:89692911 | COSM5123 | G>D | A:132 | (34.78, 90.79, 33.86) |
| 10:89692913 | COSM5044 | V>I | A:133 | (36.69, 87.84, 35.11) |
| 10:89692916 | COSM1349531 | M>V | A:134 | (40.08, 90.25, 35.56) |
| 10:89692917 | COSM1577257 | M>T | A:134 | (40.08, 90.25, 35.56) |
| 10:89692918 | COSM921092 | M>I | A:134 | (40.08, 90.25, 35.56) |
| 10:89692920 | COSM5243 | I>K | A:135 | (36.72, 94.19, 36.53) |
| 10:89692922 | COSM5096 | C>R | A:136 | (34.74, 91.29, 39.22) |
| 10:89692923 | COSM12734 | C>Y | A:136 | (34.74, 91.29, 39.22) |
| 10:89692929 | COSM5145 | Y>C | A:138 | (39.85, 95.75, 41.72) |
| 10:89692937 | COSM5077 | H>Y | A:141 | (41.82, 92.65, 45.99) |
| 10:89692938 | COSM1349538 | H>R | A:141 | (41.82, 92.65, 45.99) |
| 10:89692940 | COSM5122 | R>W | A:142 | (39.44, 98.34, 47.18) |
| 10:89692941 | COSM1349539 | R>L | A:142 | (39.44, 98.34, 47.18) |
| 10:89692946 | COSM1577253 | K>Q | A:144 | (32.96, 97.98, 46.58) |
| 10:89692947 | COSM921096 | K>T | A:144 | (32.96, 97.98, 46.58) |
| 10:89692949 | COSM27633 | F>I | A:145 | (30.95, 94.25, 45.62) |
| 10:89692952 | COSM5182 | L>V | A:146 | (32.29, 90.77, 50.27) |
| 10:89692958 | COSM5071 | A>T | A:148 | (30.75, 86.86, 43.54) |
| 10:89692964 | COSM5210 | E>Q | A:150 | (27.55, 90.86, 45.38) |
| 10:89692965 | COSM1349545 | E>A | A:150 | (27.55, 90.86, 45.38) |
| 10:89692967 | COSM5080 | A>T | A:151 | (30.20, 91.43, 41.20) |
| 10:89692971 | COSM326268 | L>P | A:152 | (29.26, 88.65, 38.71) |
| 10:89692973 | COSM5083 | D>N | A:153 | (25.03, 90.63, 39.22) |
| 10:89692976 | COSM1577265 | F>V | A:154 | (27.98, 96.36, 39.66) |
| 10:89692979 | COSM5038 | Y>H | A:155 | (30.61, 93.73, 34.02) |
| 10:89692980 | COSM5144 | Y>C | A:155 | (30.61, 93.73, 34.02) |
| 10:89692982 | COSM5103 | G>R | A:156 | (26.15, 93.72, 33.91) |
| 10:89692985 | COSM1577254 | E>K | A:157 | (23.18, 95.61, 36.31) |
| 10:89692993 | COSM5287 | R>S | A:159 | (29.63, 96.90, 29.33) |
| 10:89692998 | COSM41773 | R>K | A:161 | (21.70, 98.54, 27.29) |
| 10:89693000 | COSM5274 | D>H | A:162 | (21.19, 92.09, 28.54) |
| 10:89693001 | COSM1167954 | D>V | A:162 | (21.19, 92.09, 28.54) |
| 10:89693003 | COSM1561205 | K>E | A:163 | (20.89, 91.91, 33.31) |
| 10:89693007 | COSM1349555 | K>R | A:164 | (23.35, 88.81, 29.35) |
| 10:89711876 | COSM5114 | G>E | A:165 | (28.15, 89.32, 31.06) |
| 10:89711881 | COSM5225 | T>P | A:167 | (27.60, 84.30, 30.73) |
| 10:89711893 | COSM5200 | Q>E | A:171 | (34.45, 83.26, 32.19) |
| 10:89711894 | COSM5244 | Q>P | A:171 | (34.45, 83.26, 32.19) |
| 10:89711899 | COSM5089 | R>C | A:173 | (34.03, 77.86, 37.71) |
| 10:89711900 | COSM5039 | R>H | A:173 | (34.03, 77.86, 37.71) |
| 10:89711902 | COSM5221 | Y>N | A:174 | (38.56, 80.45, 37.31) |
| 10:89711906 | COSM1349560 | V>A | A:175 | (35.07, 85.16, 40.20) |
| 10:89711935 | COSM216385 | H>D | A:185 | (42.52, 85.48, 54.50) |
| 10:89711948 | COSM1745951 | R>K | A:189 | (50.68, 75.66, 47.85) |
| 10:89711975 | COSM28912 | M>K | A:198 | (34.46, 61.49, 34.12) |
| 10:89711993 | COSM4165560 | P>Q | A:204 | (23.39, 62.82, 26.92) |
| 10:89711997 | COSM5072 | M>I | A:205 | (19.35, 64.02, 24.58) |
| 10:89717619 | COSM212632 | F>S | A:215 | (37.02, 62.39, 26.82) |
| 10:89717621 | COSM4774921 | V>L | A:216 | (39.73, 66.01, 25.01) |
| 10:89717640 | COSM5070 | V>A | A:222 | (48.80, 70.43, 26.62) |
| 10:89717654 | COSM1349571 | S>P | A:227 | (38.76, 59.37, 24.06) |
| 10:89717664 | COSM23550 | G>E | A:230 | (32.54, 55.96, 24.23) |
| 10:89717673 | COSM1297486 | R>Q | A:233 | (30.40, 51.39, 33.38) |
| 10:89717687 | COSM36318 | F>L | A:238 | (24.12, 56.46, 35.86) |
| 10:89717696 | COSM35849 | F>L | A:241 | (33.29, 58.54, 30.73) |
| 10:89717706 | COSM1745952 | P>R | A:244 | (43.31, 53.89, 31.39) |
| 10:89717716 | COSM685102 | L>F | A:247 | (45.30, 61.89, 34.19) |
| 10:89717726 | COSM5220 | G>C | A:251 | (45.63, 73.13, 37.92) |
| 10:89717727 | COSM5286 | G>V | A:251 | (45.63, 73.13, 37.92) |
| 10:89717730 | COSM5125 | D>G | A:252 | (44.29, 75.55, 35.29) |
| 10:89717733 | COSM5230 | I>N | A:253 | (41.84, 70.91, 33.91) |
| 10:89717739 | COSM5046 | V>A | A:255 | (36.95, 68.73, 30.04) |
| 10:89717763 | COSM1349588 | K>R | A:263 | (28.72, 57.37, 8.33) |
| 10:89717766 | COSM3441285 | M>R | A:264 | (29.00, 62.62, 9.44) |
| 10:89720659 | COSM921139 | M>I | A:270 | (28.40, 67.51, 23.90) |
| 10:89720660 | COSM1349590 | F>L | A:271 | (29.99, 69.13, 27.87) |
| 10:89720661 | COSM308352 | F>S | A:271 | (29.99, 69.13, 27.87) |
| 10:89720663 | COSM5066 | H>Y | A:272 | (33.21, 73.56, 27.40) |
| 10:89720664 | COSM13458 | H>R | A:272 | (33.21, 73.56, 27.40) |
| 10:89720670 | COSM1349593 | W>L | A:274 | (39.15, 75.54, 31.49) |
| 10:89720672 | COSM921140 | V>L | A:275 | (38.65, 73.07, 37.03) |
| 10:89720679 | COSM35645 | T>I | A:277 | (43.55, 71.11, 41.32) |
| 10:89720802 | COSM1349614 | L>P | A:318 | (33.70, 67.92, 41.69) |
| 10:89720818 | COSM5209 | N>K | A:323 | (23.53, 75.11, 35.69) |
| 10:89720822 | COSM1349616 | L>F | A:325 | (28.41, 72.54, 32.32) |
| 10:89720823 | COSM86052 | L>P | A:325 | (28.41, 72.54, 32.32) |
| 10:89720826 | COSM5128 | D>G | A:326 | (30.74, 76.25, 29.48) |
| 10:89720864 | COSM23657 | P>S | A:339 | (16.94, 68.29, 34.06) |
| 10:89720865 | COSM5148 | P>L | A:339 | (16.94, 68.29, 34.06) |
| 10:89720870 | COSM5255 | F>V | A:341 | (23.77, 66.30, 33.14) |
| 10:89720871 | COSM27635 | F>C | A:341 | (23.77, 66.30, 33.14) |
| 10:89720874 | COSM1349625 | K>R | A:342 | (24.58, 65.93, 38.08) |
| 10:89725047 | COSM1349627 | K>E | A:344 | (29.81, 63.15, 39.81) |
| 10:89725048 | COSM5067 | K>R | A:344 | (29.81, 63.15, 39.81) |
| 10:89725051 | COSM5213 | L>Q | A:345 | (34.89, 64.95, 38.48) |
| 10:89725059 | COSM1349631 | T>A | A:348 | (43.42, 60.86, 44.37) |