General Structure Information
| PDB ID | 1taz |
| HGNC Gene Label(s) | PDE1B |
| Structure Name | catalytic domain of human phosphodiesterase 1b |
| Resolution | 1.77Å |
| Reference | AUTH K.Y.J.ZHANG,G.L.CARD,Y.SUZUKI,D.R.ARTIS,D.FONG,S.GILLETTE,AUTH 2 D.HSIEH,J.NEIMAN,B.L.WEST,C.ZHANG,M.V.MILBURN,S.-H.KIM,AUTH 3 J.SCHLESSINGER,G.BOLLAGTITL A GLUTAMINE SWITCH MECHANISM FOR NUCLEOTIDE SELECTIVITY BYTITL 2 PHOSPHODIESTERASESREF MOL.CELL V. 15 279 2004REFN ISSN 1097-2765PMID 15260978DOI 10.1016/J.MOLCEL.2004.07.005 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 321 |
| Number Of SNVs | 54 |
| Number Of Permutations | 8251 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.038 |
| p-value | 0.356 |
COSMIC
| Number Of Residues | 321 |
| Number Of SNVs | 6 |
| Number Of Permutations | 382 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.067 |
| p-value | 0.727 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 54 |
| Number Of COSMIC SNVs | 9 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.182 |
| p-value | 0.45 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
