Assessment of Structural Intolerance and Durability
General Structure Information 2zix MUS81 crystal structure of the mus81-eme1 complex 3.5Å AUTH J.H.CHANG,J.J.KIM,J.M.CHOI,J.H.LEE,Y.CHOTITL CRYSTAL STRUCTURE OF THE MUS81-EME1 COMPLEXREF GENES DEV. V. 22 1093 2008REFN ISSN 0890-9369PMID 18413719DOI 10.1101/GAD.1618708 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ewf HDAC8 crystal structure analysis of human hdac8 h143a variant complexed with substrate. 2.5Å AUTH D.P.DOWLING,S.L.GANTT,S.G.GATTIS,C.A.FIERKE,AUTH 2 D.W.CHRISTIANSONTITL STRUCTURAL STUDIES OF HUMAN HISTONE DEACETYLASE 8TITL 2 AND ITS SITE-SPECIFIC VARIANTS COMPLEXED WITHTITL 3 SUBSTRATE AND INHIBITORS.REF BIOCHEMISTRY V. 47 13554 2008REFN ISSN 0006-2960PMID 19053282DOI 10.1021/BI801610C Variant Set Distributions Pathogenic Proximity Analysis Mapped […]
General Structure Information 3tvl THTPA complex between the human thiamine triphosphatase and triphosphate 2.3Å AUTH D.DELVAUX,F.KERFF,M.R.MURTY,B.LAKAYE,J.CZERNIECKI,G.KOHN,AUTH 2 P.WINS,R.HERMAN,V.GABELICA,F.HEUZE,X.TORDOIR,R.MAREE,AUTH 3 A.MATAGNE,P.CHARLIER,E.DE PAUW,L.BETTENDORFFTITL STRUCTURAL DETERMINANTS OF SPECIFICITY AND CATALYTICTITL 2 MECHANISM IN MAMMALIAN 25-KDA THIAMINE TRIPHOSPHATASE.REF BIOCHIM.BIOPHYS.ACTA V.1830 4513 2013REFN ISSN 0006-3002PMID 23707715DOI 10.1016/J.BBAGEN.2013.05.014 Variant Set Distributions Mapped Variants
General Structure Information 2mc3 MUS81 nmr solution structure of the winged-helix domain from mus81 structure-specific endonuclease -1.0Å AUTH A.J.FADDEN,S.SCHALBETTER,M.BOWLES,R.HARRIS,J.LALLY,A.M.CARR,AUTH 2 N.Q.MCDONALDTITL A WINGED HELIX DOMAIN IN HUMAN MUS81 BINDS DNA AND MODULATESTITL 2 THE ENDONUCLEASE ACTIVITY OF MUS81 COMPLEXES.REF NUCLEIC ACIDS RES. V. 41 9741 2013REFN ISSN 0305-1048PMID 23982516DOI 10.1093/NAR/GKT760 Variant Set Distributions Mapped Variants
General Structure Information 2bmj AGAP2 gtpase like domain of centaurin gamma 1 (human) 2.1Å AUTH M.SOUNDARARAJAN,X.YANG,J.M.ELKINS,F.SOBOTT,D.A.DOYLETITL THE CENTAURIN GAMMA-1 GTPASE-LIKE DOMAIN FUNCTIONS AS ANTITL 2 NTPASE.REF BIOCHEM.J. V. 401 679 2007REFN ISSN 0264-6021PMID 17037982DOI 10.1042/BJ20060555 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1r55 ADAM33 crystal structure of the catalytic domain of human adam 33 1.58Å AUTH P.ORTH,P.REICHERT,W.WANG,W.W.PROSISE,T.YAROSH-TOMAINE,AUTH 2 G.HAMMOND,L.XIAO,U.A.MIRZA,J.ZOU,C.STRICKLAND,S.S.TAREMI,AUTH 3 H.V.LE,V.MADISONTITL CRYSTAL STRUCTRE OF THE CATALYTIC DOMAIN OF HUMAN ADAM33REF J.MOL.BIOL. V. 335 129 2004REFN ISSN 0022-2836PMID 14659745DOI 10.1016/J.JMB.2003.10.037 Variant Set Distributions Mapped Variants
General Structure Information 3pja TSNAX crystal structure of human c3po complex 3.0Å AUTH X.YE,N.HUANG,Y.LIU,Z.PAROO,C.HUERTA,P.LI,S.CHEN,Q.LIU,AUTH 2 H.ZHANGTITL STRUCTURE OF C3PO AND MECHANISM OF HUMAN RISC ACTIVATION.REF NAT.STRUCT.MOL.BIOL. V. 18 650 2011REFN ISSN 1545-9993PMID 21552258DOI 10.1038/NSMB.2032 Variant Set Distributions Mapped Variants
General Structure Information 4gfv PTPN18 ptpn18 in complex with her2-py1196 phosphor-peptides 2.1Å AUTH H.M.WANG,F.YANG,Y.J.DU,D.X.YANG,Y.ZHANG,X.YU,J.P.SUNTITL PTPN18-HER2 PEPTIDESREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1r42 ACE2 native human angiotensin converting enzyme-related carboxypeptidase (ace2) 2.2Å AUTH P.TOWLER,B.STAKER,S.G.PRASAD,S.MENON,J.TANG,T.PARSONS,AUTH 2 D.RYAN,M.FISHER,D.WILLIAMS,N.A.DALES,M.A.PATANE,AUTH 3 M.W.PANTOLIANOTITL ACE2 X-RAY STRUCTURES REVEAL A LARGE HINGE-BENDING MOTIONTITL 2 IMPORTANT FOR INHIBITOR BINDING AND CATALYSIS.REF J.BIOL.CHEM. V. 279 17996 2004REFN ISSN 0021-9258PMID 14754895DOI 10.1074/JBC.M311191200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3k1z HDHD3 crystal structure of human haloacid dehalogenase-like hydrolase domain containing 3 (hdhd3) 1.55Å AUTH E.UGOCHUKWU,K.GUO,W.W.YUE,E.PILKA,K.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN HALOACID DEHALOGENASE-LIKETITL 2 HYDROLASE DOMAIN CONTAINING 3 (HDHD3)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants