Assessment of Structural Intolerance and Durability
General Structure Information 3g65 RAD9A crystal structure of the human rad9-rad1-hus1 dna damage checkpoint complex 2.9Å AUTH A.S.DORE,M.L.KILKENNY,N.J.RZECHORZEK,L.H.PEARLTITL CRYSTAL STRUCTURE OF THE RAD9-RAD1-HUS1 DNA DAMAGETITL 2 CHECKPOINT COMPLEX–IMPLICATIONS FOR CLAMP LOADING ANDTITL 3 REGULATION.REF MOL.CELL V. 34 735 2009REFN ISSN 1097-2765PMID 19446481DOI 10.1016/J.MOLCEL.2009.04.027 Variant Set Distributions Mapped Variants
General Structure Information 3eay SENP7 crystal structure of the human senp7 catalytic domain 2.4Å AUTH C.D.LIMA,D.REVERTERTITL STRUCTURE OF THE HUMAN SENP7 CATALYTIC DOMAIN ANDTITL 2 POLY-SUMO DECONJUGATION ACTIVITIES FOR SENP6 ANDTITL 3 SENP7.REF J.BIOL.CHEM. V. 283 32045 2008REFN ISSN 0021-9258PMID 18799455DOI 10.1074/JBC.M805655200 Variant Set Distributions Mapped Variants
General Structure Information 3iv1 TSG101 coiled-coil domain of tumor susceptibility gene 101 2.5Å AUTH D.NECULAI,G.V.AVVAKUMOV,A.K.WERNIMONT,S.XUE,AUTH 2 J.R.WALKER,Y.LI,J.WEIGELT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 3 A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL COILED-COIL DOMAIN OF HUMAN TSG101REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2j4e ITPA the itp complex of human inosine triphosphatase 2.8Å AUTH P.STENMARK,P.KURSULA,S.FLODIN,S.GRASLUND,R.LANDRY,AUTH 2 P.NORDLUND,H.SCHULERTITL CRYSTAL STRUCTURE OF HUMAN INOSINE TRIPHOSPHATASE:TITL 2 SUBSTRATE BINDING AND IMPLICATION OF THE INOSINETITL 3 TRIPHOSPHATASE DEFICIENCY MUTATION P32T.REF J.BIOL.CHEM. V. 282 3182 2007REFN ISSN 0021-9258PMID 17138556DOI 10.1074/JBC.M609838200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1y97 TREX2 the human trex2 3 exonuclease structure suggests a mechanism for efficient non-processive dna catalysis 2.5Å AUTH F.W.PERRINO,S.HARVEY,S.MCMILLIN,T.HOLLISTITL THE HUMAN TREX2 3 -> 5-EXONUCLEASE STRUCTURETITL 2 SUGGESTS A MECHANISM FOR EFFICIENT NONPROCESSIVETITL 3 DNA CATALYSIS.REF J.BIOL.CHEM. V. 280 15212 2005REFN ISSN 0021-9258PMID 15661738DOI 10.1074/JBC.M500108200 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2i3b NTPCR solution structure of a human cancer-related nucleoside triphosphatase -1.0Å AUTH W.J.PLACZEK,M.S.ALMEIDA,K.WUTHRICHTITL NMR STRUCTURE AND FUNCTIONAL CHARACTERIZATION OF ATITL 2 HUMAN CANCER-RELATED NUCLEOSIDE TRIPHOSPHATASE.REF J.MOL.BIOL. V. 367 788 2007REFN ISSN 0022-2836PMID 17291528DOI 10.1016/J.JMB.2007.01.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3hlt HDHD2 the crystal structure of human haloacid dehalogenase-like hydrolase domain containing 2 (hdhd2) 2.3Å AUTH E.UGOCHUKWU,N.SHAFQAT,W.W.YUE,R.COCKING,J.E.BRAY,AUTH 2 J.R.C.MUNIZ,T.KROJER,F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 3 J.WEIGELT,A.EDWARDS,U.OPPERMANN,AUTH 4 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL THE CRYSTAL STRUCTURE OF HUMAN HALOACID DEHALOGENASE-LIKETITL 2 HYDROLASE DOMAIN CONTAINING 2 (HDHD2)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3bxw CHID1 crystal structure of stabilin-1 interacting chitinase-like protein, si-clp 2.7Å AUTH G.MENG,Y.ZHAO,X.BAI,Y.LIU,T.J.GREEN,M.LUO,X.ZHENGTITL STRUCTURE OF HUMAN STABILIN-1 INTERACTING CHITINASE-LIKETITL 2 PROTEIN (SI-CLP) REVEALS A SACCHARIDE-BINDING CLEFT WITHTITL 3 LOWER SUGAR-BINDING SELECTIVITY.REF J.BIOL.CHEM. V. 285 39898 2010REFN ISSN 0021-9258PMID 20724479DOI 10.1074/JBC.M110.130781 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4b04 DUSP26 crystal structure of the catalytic domain of human dusp26 (c152s) 2.2Å AUTH E.-Y.WON,Y.XIE,C.TAKEMOTO,L.CHEN,Z.-J.LIU,B.C.WANG,D.LEE,AUTH 2 E.-J.WOO,S.G.PARK,M.SHIROUZU,S.YOKOYAMA,S.J.KIM,S.-W.CHITITL HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE CATALYTIC DOMAINTITL 2 OF HUMAN DUAL-SPECIFICITY PHOSPHATASE 26REF ACTA CRYSTALLOGR.,SECT.D V. 69 1160 2013REFN ISSN 0907-4449PMID 23695260DOI 10.1107/S0907444913004770 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2bo9 LXN human carboxypeptidase a4 in complex with human latexin. 1.6Å AUTH I.PALLARES,R.BONET,R.GARCIA-CASTELLANOS,S.VENTURA,AUTH 2 F.X.AVILES,J.VENDRELL,F.X.GOMIS-RUETHTITL STRUCTURE OF HUMAN CARBOXYPEPTIDASE A4 WITH ITSTITL 2 ENDOGENOUS PROTEIN INHIBITOR, LATEXIN.REF PROC.NATL.ACAD.SCI.USA V. 102 3978 2005REFN ISSN 0027-8424PMID 15738388DOI 10.1073/PNAS.0500678102 Variant Set Distributions Mapped Variants