General Structure Information
| PDB ID | 3k1z |
| HGNC Gene Label(s) | HDHD3 |
| Structure Name | crystal structure of human haloacid dehalogenase-like hydrolase domain containing 3 (hdhd3) |
| Resolution | 1.55Å |
| Reference | AUTH E.UGOCHUKWU,K.GUO,W.W.YUE,E.PILKA,K.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN HALOACID DEHALOGENASE-LIKETITL 2 HYDROLASE DOMAIN CONTAINING 3 (HDHD3)REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 238 |
| Number Of SNVs | 71 |
| Number Of Permutations | 10990 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.14 |
| p-value | 0.043 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 9:116136603 | rs116358979 | T>M | A:11 | (-1.37, 5.31, 10.38) |
| 9:116136585 | T>M | A:17 | (-11.90, 5.71, 14.22) | |
| 9:116136570 | rs148070774 | R>H | A:22 | (-25.88, 1.65, 10.16) |
| 9:116136558 | G>E | A:26 | (-27.69, -10.48, 15.21) | |
| 9:116136549 | Y>C | A:29 | (-25.68, -12.75, 10.80) | |
| 9:116136546 | rs543319495 | A>V | A:30 | (-31.79, -12.40, 11.86) |
| 9:116136541 | rs200699842 | K>E | A:32 | (-30.43, -11.67, 5.53) |
| 9:116136538 | rs375470765 | A>T | A:33 | (-32.75, -15.15, 7.89) |
| 9:116136534 | rs375148002 | R>Q | A:34 | (-37.91, -12.94, 9.57) |
| 9:116136528 | rs200524700 | H>R | A:36 | (-33.42, -15.78, 2.81) |
| 9:116136529 | H>Y | A:36 | (-33.42, -15.78, 2.81) | |
| 9:116136511 | P>S | A:42 | (-30.93, -12.42, 17.63) | |
| 9:116136508 | S>P | A:43 | (-29.38, -14.22, 21.04) | |
| 9:116136473 | rs75660101 | R>S | A:54 | (-13.85, -18.65, 20.49) |
| 9:116136468 | Q>P | A:56 | (-12.19, -20.59, 12.16) | |
| 9:116136469 | rs150106848 | Q>E | A:56 | (-12.19, -20.59, 12.16) |
| 9:116136451 | rs199533103 | N>D | A:62 | (-4.73, -13.85, 9.47) |
| 9:116136447 | Y>C | A:63 | (-8.82, -13.53, 8.12) | |
| 9:116136444 | rs567673889 | G>D | A:64 | (-6.12, -18.97, 6.87) |
| 9:116136441 | COSM1662114 | L>R | A:65 | (-4.35, -16.69, 4.52) |
| 9:116136438 | S>T | A:66 | (-1.26, -19.90, 6.87) | |
| 9:116136433 | rs376236748 | G>S | A:68 | (-5.45, -22.96, 2.87) |
| 9:116136426 | T>N | A:70 | (-9.80, -18.05, 1.39) | |
| 9:116136423 | rs551267346 | S>C | A:71 | (-11.01, -14.71, 3.54) |
| 9:116136421 | R>C | A:72 | (-15.89, -15.92, -0.08) | |
| 9:116136392 | Q>H | A:81 | (-20.53, -23.38, 13.20) | |
| 9:116136385 | H>Y | A:84 | (-24.53, -26.14, 13.59) | |
| 9:116136378 | COSM3413272 | A>V | A:86 | (-28.40, -21.81, 16.37) |
| 9:116136379 | A>P | A:86 | (-28.40, -21.81, 16.37) | |
| 9:116136365 | rs146410311 | D>E | A:90 | (-29.22, -27.39, 5.84) |
| 9:116136357 | rs145286610 | A>V | A:93 | (-29.98, -23.22, 3.89) |
| 9:116136355 | V>I | A:94 | (-27.00, -21.27, 5.54) | |
| 9:116136338 | E>D | A:99 | (-22.48, -16.07, -0.15) | |
| 9:116136328 | K>E | A:103 | (-22.42, -8.74, -1.42) | |
| 9:116136306 | rs376236951 | T>S | A:110 | (-23.27, -2.18, 6.66) |
| 9:116136291 | D>G | A:115 | (-20.14, 12.24, 13.50) | |
| 9:116136268 | E>K | A:123 | (-8.09, 19.29, 9.43) | |
| 9:116136265 | rs201541754 | C>R | A:124 | (-4.83, 15.83, 8.24) |
| 9:116136261 | R>H | A:125 | (-5.56, 15.23, 2.61) | |
| 9:116136262 | R>C | A:125 | (-5.56, 15.23, 2.61) | |
| 9:116136256 | COSM1580224 | R>W | A:127 | (-2.11, 20.21, 9.69) |
| 9:116136227 | N>K | A:136 | (-6.44, -6.32, 12.01) | |
| 9:116136219 | rs528728306 COSM1459412 |
R>Q | A:139 | (-10.61, -9.48, 0.00) |
| 9:116136216 | R>Q | A:140 | (-14.51, -7.81, 2.99) | |
| 9:116136217 | rs76975306 | R>W | A:140 | (-14.51, -7.81, 2.99) |
| 9:116136209 | rs151332782 | E>D | A:142 | (-9.96, -0.90, -0.97) |
| 9:116136208 | G>S | A:143 | (-14.30, -1.30, -0.72) | |
| 9:116136201 | rs562968390 COSM328731 |
L>P | A:145 | (-12.93, 2.57, 2.53) |
| 9:116136198 | rs1043836 | G>E | A:146 | (-15.12, 3.28, -1.52) |
| 9:116136199 | G>R | A:146 | (-15.12, 3.28, -1.52) | |
| 9:116136183 | R>H | A:151 | (-8.68, 4.44, -0.91) | |
| 9:116136172 | D>N | A:155 | (-1.46, 7.06, 0.19) | |
| 9:116136156 | S>F | A:160 | (-3.84, -8.58, 7.90) | |
| 9:116136139 | rs200303101 | P>S | A:166 | (-1.33, -9.43, 12.65) |
| 9:116136130 | D>Y | A:169 | (3.69, -8.31, 14.14) | |
| 9:116136123 | rs201946311 | R>H | A:171 | (6.47, -9.16, 10.75) |
| 9:116136121 | rs572311264 | I>V | A:172 | (1.80, -4.68, 9.75) |
| 9:116136102 | R>Q | A:178 | (8.20, -1.03, 2.00) | |
| 9:116136093 | rs143030725 | H>R | A:181 | (9.03, 5.28, 0.87) |
| 9:116136085 | P>A | A:184 | (9.62, 5.37, 12.50) | |
| 9:116136066 | V>D | A:190 | (-4.82, 6.39, 15.07) | |
| 9:116136046 | rs570078655 | D>N | A:197 | (-3.82, 0.41, 17.68) |
| 9:116136037 | G>R | A:200 | (2.72, -1.72, 18.41) | |
| 9:116136030 | COSM1662113 | R>Q | A:202 | (4.52, 4.03, 20.88) |
| 9:116136031 | rs150788982 | R>W | A:202 | (4.52, 4.03, 20.88) |
| 9:116136006 | L>Q | A:210 | (-5.81, 4.96, 22.36) | |
| 9:116135982 | D>G | A:218 | (-8.86, -0.24, 30.63) | |
| 9:116135979 | P>L | A:219 | (-7.79, -0.26, 34.05) | |
| 9:116135971 | R>G | A:222 | (-6.31, 3.68, 35.22) | |
| 9:116135967 | rs62619247 | D>V | A:223 | (-2.85, 2.73, 35.37) |
| 9:116135961 | V>A | A:225 | (-1.49, 5.40, 28.65) | |
| 9:116135958 | rs35641844 | P>L | A:226 | (0.38, 8.56, 28.47) |
| 9:116135952 | E>G | A:228 | (-0.36, 13.30, 27.04) | |
| 9:116135928 | rs370964000 | H>R | A:236 | (-9.42, 15.39, 21.47) |
| 9:116135914 | L>F | A:241 | (-0.44, 15.92, 16.63) | |
| 9:116135908 | C>R | A:243 | (1.22, 19.23, 22.11) | |
| 9:116135904 | L>P | A:244 | (4.17, 16.07, 19.81) | |
| 9:116135896 | S>P | A:247 | (8.07, 19.71, 21.88) |