General Structure Information
| PDB ID | 1r42 |
| HGNC Gene Label(s) | ACE2 |
| Structure Name | native human angiotensin converting enzyme-related carboxypeptidase (ace2) |
| Resolution | 2.2Å |
| Reference | AUTH P.TOWLER,B.STAKER,S.G.PRASAD,S.MENON,J.TANG,T.PARSONS,AUTH 2 D.RYAN,M.FISHER,D.WILLIAMS,N.A.DALES,M.A.PATANE,AUTH 3 M.W.PANTOLIANOTITL ACE2 X-RAY STRUCTURES REVEAL A LARGE HINGE-BENDING MOTIONTITL 2 IMPORTANT FOR INHIBITOR BINDING AND CATALYSIS.REF J.BIOL.CHEM. V. 279 17996 2004REFN ISSN 0021-9258PMID 14754895DOI 10.1074/JBC.M311191200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 597 |
| Number Of SNVs | 87 |
| Number Of Permutations | 42580 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.175 |
| p-value | 0.001 |
COSMIC
| Number Of Residues | 597 |
| Number Of SNVs | 3 |
| Number Of Permutations | 254 |
| Optimal Distance Threshold | 32.0 |
| K Statistic | 0.667 |
| p-value | 0.676 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 87 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 36.0 |
| K Statistic | 0.505 |
| p-value | 0.573 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
