Assessment of Structural Intolerance and Durability
General Structure Information 2dll IRF4 solution structure of the irf domain of human interferon regulator factors 4 -1.0Å AUTH H.P.ZHANG,C.KUROSAKI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE IRF DOMAIN OF HUMANTITL 2 INTERFERON REGULATOR FACTORS 4REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4egc SIX1 crystal structure of mbp-fused human six1 bound to human eya2 eya domain 1.99Å AUTH A.N.PATRICK,J.H.CABRERA,A.L.SMITH,X.S.CHEN,H.L.FORD,R.ZHAOTITL STRUCTURE-FUNCTION ANALYSES OF THE HUMAN SIX1-EYA2 COMPLEXTITL 2 REVEAL INSIGHTS INTO METASTASIS AND BOR SYNDROME.REF NAT.STRUCT.MOL.BIOL. V. 20 447 2013REFN ISSN 1545-9993PMID 23435380DOI 10.1038/NSMB.2505 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4egc SIX1 crystal structure of mbp-fused human six1 bound to human eya2 eya domain 1.99Å AUTH A.N.PATRICK,J.H.CABRERA,A.L.SMITH,X.S.CHEN,H.L.FORD,R.ZHAOTITL STRUCTURE-FUNCTION ANALYSES OF THE HUMAN SIX1-EYA2 COMPLEXTITL 2 REVEAL INSIGHTS INTO METASTASIS AND BOR SYNDROME.REF NAT.STRUCT.MOL.BIOL. V. 20 447 2013REFN ISSN 1545-9993PMID 23435380DOI 10.1038/NSMB.2505 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4egc SIX1 crystal structure of mbp-fused human six1 bound to human eya2 eya domain 1.99Å AUTH A.N.PATRICK,J.H.CABRERA,A.L.SMITH,X.S.CHEN,H.L.FORD,R.ZHAOTITL STRUCTURE-FUNCTION ANALYSES OF THE HUMAN SIX1-EYA2 COMPLEXTITL 2 REVEAL INSIGHTS INTO METASTASIS AND BOR SYNDROME.REF NAT.STRUCT.MOL.BIOL. V. 20 447 2013REFN ISSN 1545-9993PMID 23435380DOI 10.1038/NSMB.2505 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 1g88 SMAD4 s4afl3arg515 mutant 3.0Å AUTH B.M.CHACKO,B.QIN,J.J.CORREIA,S.S.LAM,AUTH 2 M.P.DE CAESTECKER,K.LINTITL THE L3 LOOP AND C-TERMINAL PHOSPHORYLATION JOINTLYTITL 2 DEFINE SMAD PROTEIN TRIMERIZATION.REF NAT.STRUCT.BIOL. V. 8 248 2001REFN ISSN 1072-8368PMID 11224571DOI 10.1038/84995 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1x6d IL16 solution structures of the pdz domain of human interleukin- 16 -1.0Å AUTH M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURES OF THE PDZ DOMAIN OF HUMANTITL 2 INTERLEUKIN-16REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4a4p CYTH1 crystal structure of the sec7 domain from human cytohesin1 2.0Å AUTH J.C.ZEEH,A.W.THOMPSON,J.CHERFILS,V.BIOUTITL CRYSTAL STRUCTURE OF THE SEC7 DOMAIN FROM HUMAN CYTOHESIN1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2l1i HLTF nmr structure of the hltf hiran domain -1.0Å AUTH D.NECULAI,I.BEZSONOVA,J.WEIGELT,C.BOUNTRA,A.EDWARDS,AUTH 2 C.ARROWSMITH,S.DHE-PAGANONTITL NMR STRUCTURE OF THE HLTF HIRAN DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1lv2 HNF4G hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids 2.7Å AUTH G.B.WISELY,A.B.MILLER,R.G.DAVIS,A.D.JR THORNQUEST,R.JOHNSON,AUTH 2 T.SPITZER,A.SEFLER,B.SHEARER,J.T.MOORE,T.M.WILLSON,AUTH 3 S.P.WILLIAMSTITL HEPATOCYTE NUCLEAR FACTOR 4 IS A TRANSCRIPTION FACTOR THATTITL 2 CONSTITUTIVELY BINDS FATTY ACIDS.REF STRUCTURE V. 10 1225 2002REFN ISSN 0969-2126PMID 12220494DOI 10.1016/S0969-2126(02)00829-8 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4b95 TCEB1 pvhl-elob-elob-elocc complex_(2s,4r)-1-(2-chlorophenyl)carbonyl-n-[ (4-chlorophenyl)methyl]-4-oxidanyl-pyrrolidine-2-carboxamide bound 2.8Å AUTH D.L.BUCKLEY,J.L.GUSTAFSON,I.VAN MOLLE,A.G.ROTH,H.S.TAE,AUTH 2 P.C.GAREISS,W.L.JORGENSEN,A.CIULLI,C.M.CREWSTITL SMALL-MOLECULE INHIBITORS OF THE INTERACTION BETWEEN THE E3TITL 2 LIGASE VHL AND HIF1ALPHAREF ANGEW.CHEM.INT.ED.ENGL. V. 51 11463 2012REFN ISSN 1433-7851PMID 23065727DOI 10.1002/ANIE.201206231 Variant Set Distributions Mapped Variants