General Structure Information
| PDB ID | 1lv2 |
| HGNC Gene Label(s) | HNF4G |
| Structure Name | hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids |
| Resolution | 2.7Å |
| Reference | AUTH G.B.WISELY,A.B.MILLER,R.G.DAVIS,A.D.JR THORNQUEST,R.JOHNSON,AUTH 2 T.SPITZER,A.SEFLER,B.SHEARER,J.T.MOORE,T.M.WILLSON,AUTH 3 S.P.WILLIAMSTITL HEPATOCYTE NUCLEAR FACTOR 4 IS A TRANSCRIPTION FACTOR THATTITL 2 CONSTITUTIVELY BINDS FATTY ACIDS.REF STRUCTURE V. 10 1225 2002REFN ISSN 0969-2126PMID 12220494DOI 10.1016/S0969-2126(02)00829-8 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 222 |
| Number Of SNVs | 51 |
| Number Of Permutations | 19774 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.191 |
| p-value | 0.044 |
COSMIC
| Number Of Residues | 222 |
| Number Of SNVs | 8 |
| Number Of Permutations | 3661 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.071 |
| p-value | 0.166 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 51 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | -0.094 |
| p-value | 0.461 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
