Assessment of Structural Intolerance and Durability
General Structure Information 2qrv DNMT3A structure of dnmt3a-dnmt3l c-terminal domain complex 2.89Å AUTH D.JIA,R.Z.JURKOWSKA,X.ZHANG,A.JELTSCH,X.CHENGTITL STRUCTURE OF DNMT3A BOUND TO DNMT3L SUGGESTS ATITL 2 MODEL FOR DE NOVO DNA METHYLATION.REF NATURE V. 449 248 2007REFN ISSN 0028-0836PMID 17713477DOI 10.1038/NATURE06146 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4h6y FARP1 crystal strucure of the dh-ph-ph domain of farp1 4.09Å AUTH X.HE,Y.C.KUO,T.J.ROSCHE,X.ZHANGTITL STRUCTURAL BASIS FOR AUTOINHIBITION OF THE GUANINETITL 2 NUCLEOTIDE EXCHANGE FACTOR FARP2.REF STRUCTURE V. 21 355 2013REFN ISSN 0969-2126PMID 23375260DOI 10.1016/J.STR.2013.01.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4bzc SAMHD1 crystal structure of the tetrameric dgtp-bound wild type samhd1 catalytic core 2.88Å AUTH X.JI,Y.WU,J.YAN,J.MEHRENS,H.YANG,M.DELUCIA,C.HAO,AUTH 2 A.M.GRONENBORN,J.SKOWRONSKI,J.AHN,Y.XIONGTITL MECHANISM OF ALLOSTERIC ACTIVATION OF SAMHD1 BY DGTPREF NAT.STRUCT.MOL.BIOL. V. 20 1304 2013REFN ISSN 1545-9993PMID 24141705DOI 10.1038/NSMB.2692 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3l8n ARFGEF2 crystal structure of a domain of brefeldin a-inhibited guanine nucleotide-exchange protein 2 (brefeldina-inhibited gep 2) from homo sapiens (human). northeast structural genomics consortium target id hr5562a 2.86Å AUTH J.SEETHARAMAN,M.SU,F.FOROUHAR,D.WANG,H.JANJUA,AUTH 2 K.CUNNINGHAM,L.OWENS,R.XIAO,J.LIU,M.C.BARAN,AUTH 3 T.B.ACTON,G.T.MONTELIONE,J.F.HUNT,L.TONGTITL CRYSTAL STRUCTURE OF A DOMAIN OF BREFELDINTITL 2 A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 2TITL 3 (BREFELDINA-INHIBITED GEP 2) […]
General Structure Information 4cc9 VPRBP crystal structure of human samhd1 (amino acid residues 582- 626) bound to vpx isolated from sooty mangabey and human dcaf1 (amino acid residues 1058-1396) 2.47Å AUTH D.SCHWEFEL,H.C.T.GROOM,V.C.BOUCHERIT,E.CHRISTODOULOU,AUTH 2 P.A.WALKER,J.P.STOYE,K.N.BISHOP,I.A.TAYLORTITL STRUCTURAL BASIS OF LENTIVIRAL SUBVERSION OF A CELLULARTITL 2 PROTEIN DEGRADATION PATHWAY.REF NATURE V. 505 234 2014REFN ISSN 0028-0836PMID 24336198DOI 10.1038/NATURE12815 […]
General Structure Information 3ltl ARFGEF1 crystal structure of human big1 sec7 domain 2.2Å AUTH J.C.ZEEH,P.C.SIMISTER,V.ROUSSEAU,A.JOUBERT,J.CHERFILS,V.BIOUTITL THE SEC7 DOMAIN STRUCTURES OF HUMAN BIG1 AND CYTOHESIN1 ARFTITL 2 NUCLEOTIDE EXCHANGE FACTORSREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ecb ZHX1 the solution structure of the third homeobox domain of human zinc fingers and homeoboxes protein -1.0Å AUTH S.OHNISHI,N.TOCHIO,A.SASAGAWA,K.SAITO,S.KOSHIBA,AUTH 2 M.INOUE,T.KIGAWA,S.YOKOYAMATITL THE SOLUTION STRUCTURE OF THE THIRD HOMEOBOXTITL 2 DOMAIN OF HUMAN ZINC FINGERS AND HOMEOBOXES PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 1txu RABGEF1 crystal structure of the vps9 domain of rabex-5 2.35Å AUTH A.DELPRATO,E.MERITHEW,D.G.LAMBRIGHTTITL STRUCTURE, EXCHANGE DETERMINANTS, AND FAMILY-WIDETITL 2 RAB SPECIFICITY OF THE TANDEM HELICAL BUNDLE ANDTITL 3 VPS9 DOMAINS OF RABEX-5REF CELL(CAMBRIDGE,MASS.) V. 118 607 2004REFN ISSN 0092-8674PMID 15339665DOI 10.1016/J.CELL.2004.08.009 Variant Set Distributions Mapped Variants
General Structure Information 1txu KCTD7 crystal structure of the vps9 domain of rabex-5 2.35Å AUTH A.DELPRATO,E.MERITHEW,D.G.LAMBRIGHTTITL STRUCTURE, EXCHANGE DETERMINANTS, AND FAMILY-WIDETITL 2 RAB SPECIFICITY OF THE TANDEM HELICAL BUNDLE ANDTITL 3 VPS9 DOMAINS OF RABEX-5REF CELL(CAMBRIDGE,MASS.) V. 118 607 2004REFN ISSN 0092-8674PMID 15339665DOI 10.1016/J.CELL.2004.08.009 Variant Set Distributions Mapped Variants
General Structure Information 1wwx ELF5 solution structure of the ets-domain of the ets domain transcription factor -1.0Å AUTH A.GORONCY,T.KIGAWA,S.KOSHIBA,N.KOBAYASHI,N.TOCHIO,AUTH 2 M.INOUE,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ETS-DOMAIN OF THE ETSTITL 2 DOMAIN TRANSCRIPTION FACTORREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants