Assessment of Structural Intolerance and Durability
General Structure Information 4mxw LTBR structure of heterotrimeric lymphotoxin lta1b2 bound to lymphotoxin beta receptor ltbr and anti-lta fab 3.6Å AUTH J.SUDHAMSU,J.YIN,E.Y.CHIANG,M.A.STAROVASNIK,J.L.GROGAN,AUTH 2 S.G.HYMOWITZTITL DIMERIZATION OF LT BETA R BY LT ALPHA 1 BETA 2 IS NECESSARYTITL 2 AND SUFFICIENT FOR SIGNAL TRANSDUCTION.REF PROC.NATL.ACAD.SCI.USA V. 110 19896 2013REFN ISSN 0027-8424PMID 24248355DOI 10.1073/PNAS.1310838110 Variant Set Distributions […]
General Structure Information 2v5e GDNF the structure of the gdnf:coreceptor complex: insights into ret signalling and heparin binding. 2.35Å AUTH V.PARKASH,V.-M.LEPPANEN,H.VIRTANEN,J.-M.JURVANSUU,AUTH 2 M.M.BESPALOV,Y.A.SIDOROVA,P.RUNEBERG-ROOS,M.SAARMA,AUTH 3 A.GOLDMANTITL THE STRUCTURE OF THE GLIAL CELL LINE-DERIVEDTITL 2 NEUROTROPHIC FACTOR-CORECEPTOR COMPLEX: INSIGHTSTITL 3 INTO RET SIGNALING AND HEPARIN BINDING.REF J.BIOL.CHEM. V. 283 35164 2008REFN ISSN 0021-9258PMID 18845535DOI 10.1074/JBC.M802543200 Variant Set […]
General Structure Information 3tje FAS crystal structure of fas receptor extracellular domain in complex with fab e09 1.93Å AUTH M.CHODORGE,S.ZUGER,C.STIRNIMANN,C.BRIAND,L.JERMUTUS,AUTH 2 M.G.GRUTTER,R.R.MINTERTITL A SERIES OF FAS RECEPTOR AGONIST ANTIBODIES THAT DEMONSTRATETITL 2 AN INVERSE CORRELATION BETWEEN AFFINITY AND POTENCY.REF CELL DEATH DIFFER. V. 19 1187 2012REFN ISSN 1350-9047PMID 22261618DOI 10.1038/CDD.2011.208 Variant Set Distributions Mapped Variants
General Structure Information 1cnt CNTF ciliary neurotrophic factor 2.4Å AUTH N.Q.MCDONALD,N.PANAYOTATOS,W.A.HENDRICKSONTITL CRYSTAL STRUCTURE OF DIMERIC HUMAN CILIARYTITL 2 NEUROTROPHIC FACTOR DETERMINED BY MAD PHASING.REF EMBO J. V. 14 2689 1995REFN ISSN 0261-4189PMID 7796798 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1nt3 NTF3 human neurotrophin-3 2.4Å AUTH M.J.BUTTE,P.K.HWANG,W.C.MOBLEY,R.J.FLETTERICKTITL CRYSTAL STRUCTURE OF NEUROTROPHIN-3 HOMODIMER SHOWS DISTINCTTITL 2 REGIONS ARE USED TO BIND ITS RECEPTORS.REF BIOCHEMISTRY V. 37 16846 1998REFN ISSN 0006-2960PMID 9836577DOI 10.1021/BI981254O Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1iil FGFR2 crystal structure of pro253arg apert mutant fgf receptor 2 (fgfr2) in complex with fgf2 2.3Å AUTH O.A.IBRAHIMI,A.V.ELISEENKOVA,A.N.PLOTNIKOV,K.YU,AUTH 2 D.M.ORNITZ,M.MOHAMMADITITL STRUCTURAL BASIS FOR FIBROBLAST GROWTH FACTORTITL 2 RECEPTOR 2 ACTIVATION IN APERT SYNDROME.REF PROC.NATL.ACAD.SCI.USA V. 98 7182 2001REFN ISSN 0027-8424PMID 11390973DOI 10.1073/PNAS.121183798 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2r53 BMP6 crystal structure analysis of bone morphogenetic protein-6 variant b2 (b2-bmp-6) 2.1Å AUTH S.SAREMBA,J.NICKEL,A.SEHER,A.KOTZSCH,W.SEBALD,AUTH 2 T.D.MUELLERTITL TYPE I RECEPTOR BINDING OF BONE MORPHOGENETICTITL 2 PROTEIN 6 IS DEPENDENT ON N-GLYCOSYLATION OF THETITL 3 LIGAND.REF FEBS J. V. 275 172 2007REFN ISSN 1742-464XPMID 18070108DOI 10.1111/J.1742-4658.2007.06187.X Variant Set Distributions Mapped Variants