Assessment of Structural Intolerance and Durability
General Structure Information 1f3u GTF2F1 crystal structure of the rap30/74 interaction domains of human tfiif 1.7Å AUTH F.GAISER,S.TAN,T.J.RICHMONDTITL NOVEL DIMERIZATION FOLD OF RAP30/RAP74 IN HUMANTITL 2 TFIIF AT 1.7 A RESOLUTION.REF J.MOL.BIOL. V. 302 1119 2000REFN ISSN 0022-2836PMID 11183778DOI 10.1006/JMBI.2000.4110 Variant Set Distributions Mapped Variants
General Structure Information 1g82 FGF9 structure of fibroblast growth factor 9 2.6Å AUTH H.J.HECHT,R.ADAR,B.HOFMANN,O.BOGIN,H.WEICH,A.YAYONTITL STRUCTURE OF FIBROBLAST GROWTH FACTOR 9 SHOWS A SYMMETRICTITL 2 DIMER WITH UNIQUE RECEPTOR- AND HEPARIN-BINDING INTERFACES.REF ACTA CRYSTALLOGR.,SECT.D V. 57 378 2001REFN ISSN 0907-4449PMID 11223514DOI 10.1107/S0907444900020813 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1d6g CCKAR molecular complex of cholecystokinin-8 and n-terminus of the cholecystokinin a receptor by nmr spectroscopy -1.0Å AUTH M.PELLEGRINI,D.F.MIERKETITL MOLECULAR COMPLEX OF CHOLECYSTOKININ-8 ANDTITL 2 N-TERMINUS OF THE CHOLECYSTOKININ A RECEPTOR BYTITL 3 NMR SPECTROSCOPY.REF BIOCHEMISTRY V. 38 14775 1999REFN ISSN 0006-2960PMID 10555959DOI 10.1021/BI991272L Variant Set Distributions Mapped Variants
General Structure Information 2dao ETV6 solution structure of ets domain transcriptional factor etv6 protein -1.0Å AUTH T.N.NIRAULA,A.SASAGAWA,T.TOMIZAWA,S.KOSHIBA,AUTH 2 M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF ETS DOMAIN TRANSCRIPTIONALTITL 2 FACTOR ETV6 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1am9 SREBF1 human srebp-1a bound to ldl receptor promoter 2.3Å AUTH A.PARRAGA,L.BELLSOLELL,A.R.FERRE-DAMARE,S.K.BURLEYTITL CO-CRYSTAL STRUCTURE OF STEROL REGULATORY ELEMENTTITL 2 BINDING PROTEIN 1A AT 2.3 A RESOLUTION.REF STRUCTURE V. 6 661 1998REFN ISSN 0969-2126PMID 9634703DOI 10.1016/S0969-2126(98)00067-7 Variant Set Distributions Mapped Variants
General Structure Information 1ax8 LEP human obesity protein, leptin 2.4Å AUTH F.ZHANG,M.B.BASINSKI,J.M.BEALS,S.L.BRIGGS,L.M.CHURGAY,AUTH 2 D.K.CLAWSON,R.D.DIMARCHI,T.C.FURMAN,J.E.HALE,H.M.HSIUNG,AUTH 3 B.E.SCHONER,D.P.SMITH,X.Y.ZHANG,J.P.WERY,R.W.SCHEVITZTITL CRYSTAL STRUCTURE OF THE OBESE PROTEIN LEPTIN-E100.REF NATURE V. 387 206 1997REFN ISSN 0028-0836PMID 9144295DOI 10.1038/387206A0 Variant Set Distributions Mapped Variants
General Structure Information 4iqr HNF4A multi-domain organization of the hnf4alpha nuclear receptor complex on dna 2.9Å AUTH V.CHANDRA,P.HUANG,N.POTLURI,D.WU,Y.KIM,F.RASTINEJADTITL MULTIDOMAIN INTEGRATION IN THE STRUCTURE OF THE HNF-4 ALPHATITL 2 NUCLEAR RECEPTOR COMPLEX.REF NATURE V. 495 394 2013REFN ISSN 0028-0836PMID 23485969DOI 10.1038/NATURE11966 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3kfd TGFBR1 ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily 3.0Å AUTH S.RADAEV,Z.ZOU,T.HUANG,E.M.LAFER,A.P.HINCK,P.D.SUNTITL TERNARY COMPLEX OF TRANSFORMING GROWTH FACTOR-BETA1 REVEALSTITL 2 ISOFORM-SPECIFIC LIGAND RECOGNITION AND RECEPTORTITL 3 RECRUITMENT IN THE SUPERFAMILY.REF J.BIOL.CHEM. V. 285 14806 2010REFN ISSN 0021-9258PMID 20207738DOI 10.1074/JBC.M109.079921 Variant Set Distributions Mapped Variants
General Structure Information 1hzn CCKAR nmr solution structure of the third extracellular loop of the cholecystokinin a receptor -1.0Å AUTH C.GIRAGOSSIAN,D.F.MIERKETITL INTERMOLECULAR INTERACTIONS BETWEENTITL 2 CHOLECYSTOKININ-8 AND THE THIRD EXTRACELLULAR LOOPTITL 3 OF THE CHOLECYSTOKININ A RECEPTOR.REF BIOCHEMISTRY V. 40 3804 2001REFN ISSN 0006-2960PMID 11300760DOI 10.1021/BI002659N Variant Set Distributions Mapped Variants
General Structure Information 1ip0 BTC nmr structure of human betacellulin-2 -1.0Å AUTH K.MIURA,H.DOURA,T.AIZAWA,H.TADA,M.SENO,H.YAMADA,AUTH 2 K.KAWANOTITL SOLUTION STRUCTURE OF BETACELLULIN, A NEW MEMBERTITL 2 OF EGF-FAMILY LIGANDS.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 294 1040 2002REFN ISSN 0006-291XPMID 12074582DOI 10.1016/S0006-291X(02)00585-5 Variant Set Distributions Mapped Variants