General Structure Information
| PDB ID | 4egc |
| HGNC Gene Label(s) | SIX1 |
| Structure Name | crystal structure of mbp-fused human six1 bound to human eya2 eya domain |
| Resolution | 1.99Å |
| Reference | AUTH A.N.PATRICK,J.H.CABRERA,A.L.SMITH,X.S.CHEN,H.L.FORD,R.ZHAOTITL STRUCTURE-FUNCTION ANALYSES OF THE HUMAN SIX1-EYA2 COMPLEXTITL 2 REVEAL INSIGHTS INTO METASTASIS AND BOR SYNDROME.REF NAT.STRUCT.MOL.BIOL. V. 20 447 2013REFN ISSN 1545-9993PMID 23435380DOI 10.1038/NSMB.2505 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 169 |
| Number Of SNVs | 24 |
| Number Of Permutations | 5378 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.333 |
| p-value | 0.761 |
ClinVar
| Number Of Residues | 169 |
| Number Of SNVs | 5 |
| Number Of Permutations | 841 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.3 |
| p-value | 0.141 |
COSMIC
| Number Of Residues | 169 |
| Number Of SNVs | 4 |
| Number Of Permutations | 16 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.167 |
| p-value | 0.741 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 24 |
| Number Of ClinVar SNVs | 5 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.22 |
| p-value | 0.086 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 24 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | -0.286 |
| p-value | 0.447 |