Assessment of Structural Intolerance and Durability
General Structure Information 4dou ADIPOQ crystal structure of a single-chain trimer of human adiponectin globular domain 2.0Å AUTH X.MIN,B.LEMON,J.TANG,Q.LIU,R.ZHANG,N.WALKER,Y.LI,Z.WANGTITL CRYSTAL STRUCTURE OF A SINGLE-CHAIN TRIMER OF HUMANTITL 2 ADIPONECTIN GLOBULAR DOMAIN.REF FEBS LETT. V. 586 912 2012REFN ISSN 0014-5793PMID 22449980DOI 10.1016/J.FEBSLET.2012.02.024 Variant Set Distributions Mapped Variants
General Structure Information 2nxp TAF5 structure of ntd2 domain of the human taf5 subunit of tfiid 2.17Å AUTH S.BHATTACHARYA,S.TAKADA,R.H.JACOBSONTITL STRUCTURAL ANALYSIS AND DIMERIZATION POTENTIAL OFTITL 2 THE HUMAN TAF5 SUBUNIT OF TFIID.REF PROC.NATL.ACAD.SCI.USA V. 104 1189 2007REFN ISSN 0027-8424PMID 17227857DOI 10.1073/PNAS.0610297104 Variant Set Distributions Mapped Variants
General Structure Information 3l4c DOCK1 structural basis of membrane-targeting by dock180 2.37Å AUTH L.PREMKUMAR,A.A.BOBKOV,M.PATEL,L.JAROSZEWSKI,L.A.BANKSTON,AUTH 2 B.STEC,K.VUORI,J.F.COTE,R.C.LIDDINGTONTITL STRUCTURAL BASIS OF MEMBRANE TARGETING BY THE DOCK180TITL 2 FAMILY OF RHO FAMILY GUANINE EXCHANGE FACTORS (RHO-GEFS).REF J.BIOL.CHEM. V. 285 13211 2010REFN ISSN 0021-9258PMID 20167601DOI 10.1074/JBC.M110.102517 Variant Set Distributions Mapped Variants
General Structure Information 1i16 IL16 structure of interleukin 16: implications for function, nmr, 20 structures -1.0Å AUTH P.MUHLHAHN,M.ZWECKSTETTER,J.GEORGESCU,C.CIOSTO,AUTH 2 C.RENNER,M.LANZENDORFER,K.LANG,D.AMBROSIUS,M.BAIER,AUTH 3 R.KURTH,T.A.HOLAKTITL STRUCTURE OF INTERLEUKIN 16 RESEMBLES A PDZ DOMAINTITL 2 WITH AN OCCLUDED PEPTIDE BINDING SITE.REF NAT.STRUCT.BIOL. V. 5 682 1998REFN ISSN 1072-8368PMID 9699630DOI 10.1038/1376 Variant Set Distributions Mapped Variants
General Structure Information 2ebt KLF5 solution structure of three tandem repeats of zf-c2h2 domains from human kruppel-like factor 5 -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THREE TANDEM REPEATS OFTITL 2 ZF-C2H2 DOMAINS FROM HUMAN KRUPPEL-LIKE FACTOR 5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ecs EIF2B1 crystal structure of human eif2b alpha 2.65Å AUTH T.B.HIYAMA,T.ITO,H.IMATAKA,S.YOKOYAMATITL CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT OF HUMAN TRANSLATIONTITL 2 INITIATION FACTOR 2BREF J.MOL.BIOL. V. 392 937 2009REFN ISSN 0022-2836PMID 19631657DOI 10.1016/J.JMB.2009.07.054 Variant Set Distributions Mapped Variants
General Structure Information 1a02 NFATC2 structure of the dna binding domains of nfat, fos and jun bound to dna 2.7Å AUTH L.CHEN,J.N.GLOVER,P.G.HOGAN,A.RAO,S.C.HARRISONTITL STRUCTURE OF THE DNA-BINDING DOMAINS FROM NFAT,TITL 2 FOS AND JUN BOUND SPECIFICALLY TO DNA.REF NATURE V. 392 42 1998REFN ISSN 0028-0836PMID 9510247DOI 10.1038/32100 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3bor EIF4A2 crystal structure of the deadc domain of human translation initiation factor 4a-2 1.85Å AUTH P.SCHUTZ,T.KARLBERG,S.VAN DEN BERG,R.COLLINS,L.LEHTIO,AUTH 2 M.HOGBOM,L.HOLMBERG-SCHIAVONE,W.TEMPEL,H.W.PARK,AUTH 3 M.HAMMARSTROM,M.MOCHE,A.G.THORSELL,H.SCHULERTITL COMPARATIVE STRUCTURAL ANALYSIS OF HUMAN DEAD-BOX RNATITL 2 HELICASES.REF PLOS ONE V. 5 12791 2010REFN ESSN 1932-6203PMID 20941364DOI 10.1371/JOURNAL.PONE.0012791 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1cf7 TFDP2 structural basis of dna recognition by the heterodimeric cell cycle transcription factor e2f-dp 2.6Å AUTH N.ZHENG,E.FRAENKEL,C.O.PABO,N.P.PAVLETICHTITL STRUCTURAL BASIS OF DNA RECOGNITION BY THETITL 2 HETERODIMERIC CELL CYCLE TRANSCRIPTION FACTORTITL 3 E2F-DP.REF GENES DEV. V. 13 666 1999REFN ISSN 0890-9369PMID 10090723 Variant Set Distributions Mapped Variants
General Structure Information 1by1 ARHGEF7 dbl homology domain from beta-pix -1.0Å AUTH B.AGHAZADEH,K.ZHU,T.J.KUBISESKI,G.A.LIU,T.PAWSON,AUTH 2 Y.ZHENG,M.K.ROSENTITL STRUCTURE AND MUTAGENESIS OF THE DBL HOMOLOGYTITL 2 DOMAINREF NAT.STRUCT.BIOL. V. 5 1098 1998REFN ISSN 1072-8368PMID 9846881DOI 10.1038/4209 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants