Assessment of Structural Intolerance and Durability
General Structure Information 3t6g SH2D3C structure of the complex between nsp3 (shep1) and p130cas 2.5Å AUTH P.D.MACE,Y.WALLEZ,M.K.DOBACZEWSKA,J.J.LEE,H.ROBINSON,AUTH 2 E.B.PASQUALE,S.J.RIEDLTITL NSP-CAS PROTEIN STRUCTURES REVEAL A PROMISCUOUS INTERACTIONTITL 2 MODULE IN CELL SIGNALING.REF NAT.STRUCT.MOL.BIOL. V. 18 1381 2011REFN ISSN 1545-9993PMID 22081014DOI 10.1038/NSMB.2152 Variant Set Distributions Mapped Variants
General Structure Information 3tw8 DENND1B gef domain of dennd 1b in complex with rab gtpase rab35 2.1Å AUTH X.WU,M.J.BRADLEY,Y.CAI,D.KUMMEL,E.M.DE LA CRUZ,F.A.BARR,AUTH 2 K.M.REINISCHTITL INSIGHTS REGARDING GUANINE NUCLEOTIDE EXCHANGE FROM THETITL 2 STRUCTURE OF A DENN-DOMAIN PROTEIN COMPLEXED WITH ITS RABTITL 3 GTPASE SUBSTRATE.REF PROC.NATL.ACAD.SCI.USA V. 108 18672 2011REFN ISSN 0027-8424PMID 22065758DOI 10.1073/PNAS.1110415108 Variant Set Distributions […]
General Structure Information 3iec MARK2 helicobacter pylori caga inhibits par1/mark family kinases by mimicking host substrates 2.2Å AUTH D.NESIC,M.C.MILLER,Z.T.QUINKERT,M.STEIN,B.T.CHAIT,AUTH 2 C.E.STEBBINSTITL HELICOBACTER PYLORI CAGA INHIBITS PAR1-MARK FAMILY KINASESTITL 2 BY MIMICKING HOST SUBSTRATES.REF NAT.STRUCT.MOL.BIOL. V. 17 130 2010REFN ISSN 1545-9993PMID 19966800DOI 10.1038/NSMB.1705 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2prg NCOA1 ligand-binding domain of the human peroxisome proliferator activated receptor gamma 2.3Å AUTH R.T.NOLTE,G.B.WISELY,S.WESTIN,J.E.COBB,M.H.LAMBERT,AUTH 2 R.KUROKAWA,M.G.ROSENFELD,T.M.WILLSON,C.K.GLASS,AUTH 3 M.V.MILBURNTITL LIGAND BINDING AND CO-ACTIVATOR ASSEMBLY OF THETITL 2 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA.REF NATURE V. 395 137 1998REFN ISSN 0028-0836PMID 9744270DOI 10.1038/25931 Variant Set Distributions Mapped Variants
General Structure Information 2lpn CDNF solution structure of n-terminal domain of human conserved dopamine neurotrophic factor (cdnf) -1.0Å AUTH C.LATGE,K.M.CABRAL,M.S.ALMEIDA,D.FOGUELTITL (1)H-, (13)C- AND (15)N-NMR ASSIGNMENT OF THE N-TERMINALTITL 2 DOMAIN OF HUMAN CEREBRAL DOPAMINE NEUROTROPHIC FACTORTITL 3 (CDNF).REF BIOMOL.NMR ASSIGN. V. 7 101 2013REFN ISSN 1874-2718PMID 22528768DOI 10.1007/S12104-012-9388-8 Variant Set Distributions Mapped Variants
General Structure Information 1i1j MIA structure of melanoma inhibitory activity protein: a member of a new family of secreted proteins 1.39Å AUTH J.C.LOUGHEED,J.M.HOLTON,T.ALBER,J.F.BAZAN,AUTH 2 T.M.HANDELTITL STRUCTURE OF MELANOMA INHIBITORY ACTIVITY PROTEIN,TITL 2 A MEMBER OF A RECENTLY IDENTIFIED FAMILY OFTITL 3 SECRETED PROTEINS.REF PROC.NATL.ACAD.SCI.USA V. 98 5515 2001REFN ISSN 0027-8424PMID 11331761DOI 10.1073/PNAS.091601698 Variant Set Distributions […]
General Structure Information 3q2t CPSF6 crystal structure of cfim68 rrm/cfim25/rna complex 3.06Å AUTH Q.YANG,M.COSENO,G.M.GILMARTIN,S.DOUBLIETITL CRYSTAL STRUCTURE OF A HUMAN CLEAVAGE FACTORTITL 2 CFI(M)25/CFI(M)68/RNA COMPLEX PROVIDES AN INSIGHT INTOTITL 3 POLY(A) SITE RECOGNITION AND RNA LOOPING.REF STRUCTURE V. 19 368 2011REFN ISSN 0969-2126PMID 21295486DOI 10.1016/J.STR.2010.12.021 Variant Set Distributions Mapped Variants
General Structure Information 4h6j HIF1A identification of cys 255 in hif-1 as a novel site for development of covalent inhibitors of hif-1 /arnt pasb domain protein-protein interaction. 1.52Å AUTH R.CARDOSO,R.LOVE,C.L.NILSSON,S.BERGQVIST,D.NOWLIN,J.YAN,AUTH 2 K.K.LIU,J.ZHU,P.CHEN,Y.L.DENG,H.J.DYSON,M.J.GREIG,A.BROOUNTITL IDENTIFICATION OF CYS255 IN HIF-1 ALPHA AS A NOVEL SITE FORTITL 2 DEVELOPMENT OF COVALENT INHIBITORS OF HIF-1 ALPHA /ARNT PASBTITL 3 DOMAIN […]
General Structure Information 3qxl RALGPS1 crystal structure of the cdc25 domain from ral-specific guanine- nucleotide exchange factor ralgps1a 2.24Å AUTH W.PENG,J.XU,X.GUAN,Y.SUN,X.C.ZHANG,X.LI,Z.RAOTITL STRUCTURAL STUDY OF THE CDC25 DOMAIN FROM RAL-SPECIFICTITL 2 GUANINE-NUCLEOTIDE EXCHANGE FACTOR RALGPS1A.REF PROTEIN CELL V. 2 308 2011REFN ISSN 1674-800XPMID 21494904DOI 10.1007/S13238-011-1036-Z Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3b6y IFI16 crystal structure of the second hin-200 domain of interferon-inducible protein 16 2.35Å AUTH J.C.C.LIAO,R.LAM,M.RAVICHANDRAN,S.DUAN,W.TEMPEL,AUTH 2 N.Y.CHIRGADZE,C.H.ARROWSMITHTITL CRYSTAL STRUCTURE ANALYSIS OF THE SECOND HIN DOMAIN OFTITL 2 IFI16.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants