Assessment of Structural Intolerance and Durability
General Structure Information 3eo2 NET1 crystal structure of the rhogef domain of human neuroepithelial cell- transforming gene 1 protein 2.6Å AUTH L.NEDYALKOVA,Y.TONG,W.TEMPEL,F.MACKENZIE,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF THE RHOGEF DOMAIN OF HUMANTITL 2 NEUROEPITHELIAL CELL-TRANSFORMING GENE 1 PROTEINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3tlp PBRM1 crystal structure of the fourth bromodomain of human poly-bromodomain containing protein 1 (pb1) 2.13Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Mapped Variants
General Structure Information 3iu6 PBRM1 crystal structure of the sixth bromodomain of human poly-bromodomain containing protein 1 (pb1) 1.79Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,M.MANGOS,T.KEATES,J.P.LAMBERT,AUTH 2 D.BARSYTE-LOVEJOY,I.FELLETAR,R.VOLKMER,S.MULLER,T.PAWSON,AUTH 3 A.C.GINGRAS,C.H.ARROWSMITH,S.KNAPPTITL HISTONE RECOGNITION AND LARGE-SCALE STRUCTURAL ANALYSIS OFTITL 2 THE HUMAN BROMODOMAIN FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 149 214 2012REFN ISSN 0092-8674PMID 22464331DOI 10.1016/J.CELL.2012.02.013 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2kuo APLF structure and identification of adp-ribose recognition motifs of aplf and role in the dna damage response -1.0Å AUTH G.Y.LI,R.D.MCCULLOCH,A.FENTON,M.CHEUNG,L.MENG,M.IKURA,AUTH 2 C.A.KOCHTITL STRUCTURE AND IDENTIFICATION OF ADP-RIBOSE RECOGNITIONTITL 2 MOTIFS OF APRATAXIN PNK-LIKE FACTOR (APLF) REQUIRED FOR THETITL 3 INTERACTION WITH SITES OF DNA DAMAGE RESPONSEREF TO BE PUBLISHEDREFN Variant Set […]
General Structure Information 4li0 RAB3IL1 crystal structure of gdp-bound rab8:grab 3.3Å AUTH Z.GUO,X.HOU,R.S.GOODY,A.ITZENTITL INTERMEDIATES IN THE GUANINE NUCLEOTIDE EXCHANGE REACTION OFTITL 2 RAB8 PROTEIN CATALYZED BY GUANINE NUCLEOTIDE EXCHANGETITL 3 FACTORS RABIN8 AND GRAB.REF J.BIOL.CHEM. V. 288 32466 2013REFN ISSN 0021-9258PMID 24072714DOI 10.1074/JBC.M113.498329 Variant Set Distributions Mapped Variants
General Structure Information 2ecc HOMEZ solution structure of the second homeobox domain of human homeodomain leucine zipper-encoding gene (homez) -1.0Å AUTH S.OHNISHI,Y.O.KAMATARI,N.TOCHIO,N.KOBAYASHI,AUTH 2 S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND HOMEOBOX DOMAINTITL 2 OF HUMAN HOMEODOMAIN LEUCINE ZIPPER-ENCODING GENETITL 3 (HOMEZ)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3k2j PBRM1 crystal structure of the 3rd bromodomain of human poly-bromodomain containing protein 1 (pb1) 2.2Å AUTH P.FILIPPAKOPOULOS,S.PICAUD,T.KEATES,A.CHAIKUAD,A.C.W.PIKE,AUTH 2 T.KROJER,R.SETHI,F.VON DELFT,C.H.ARROWSMITH,A.EDWARDS,AUTH 3 J.WEIGELT,C.BOUNTRA,S.KNAPPTITL CRYSTAL STRUCTURE OF THE 3RD BROMODOMAIN OF HUMANTITL 2 POLY-BROMODOMAIN CONTAINING PROTEIN 1 (PB1)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2jxx NFATC2IP nmr solution structure of ubiquitin-like domain of nfatc2ip. northeast structural genomics consortium target hr5627 -1.0Å AUTH R.S.DOHERTY,S.DHE-PAGANON,C.FARES,A.LEMAK,C.BUTLER,AUTH 2 S.SRISAILAM,M.KARRA,A.YEE,J.WEIGELT,A.M.EDWARDS,AUTH 3 C.H.ARROWSMITHTITL SOLUTION STRUCTURE OF UBIQUITIN-LIKE DOMAIN OFTITL 2 NFATC2IP.REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3n9u CPSF7 crystal structure of the complex between the 25 kda subunit and the 59 kda subunit (rrm domain) of human cleavage factor im 1.92Å AUTH L.TRESAUGUES,M.WELIN,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,I.JOHANSSON,T.KARLBERG,S.KOL,T.KOTENYOVA,AUTH 4 M.MOCHE,T.K.NIELSEN,T.NYMAN,C.PERSSON,H.SCHULER,P.SCHUTZ,AUTH 5 M.I.SIPONEN,A.G.THORSELL,S.VAN DER BERG,E.WAHLBERG,AUTH 6 J.WEIGELT,M.WISNIEWSKA,P.NORDLUNDTITL CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE 25 KDA SUBUNITTITL 2 AND THE […]
General Structure Information 2d93 RAPGEF6 solution structure of the cnmp_binding domain of human rap guanine nucleotide exchange factor 6 -1.0Å AUTH K.INOUE,Y.MUTO,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CNMP_BINDING DOMAIN OFTITL 2 HUMAN RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants