General Structure Information
| PDB ID | 4h6j |
| HGNC Gene Label(s) | HIF1A |
| Structure Name | identification of cys 255 in hif-1 as a novel site for development of covalent inhibitors of hif-1 /arnt pasb domain protein-protein interaction. |
| Resolution | 1.52Å |
| Reference | AUTH R.CARDOSO,R.LOVE,C.L.NILSSON,S.BERGQVIST,D.NOWLIN,J.YAN,AUTH 2 K.K.LIU,J.ZHU,P.CHEN,Y.L.DENG,H.J.DYSON,M.J.GREIG,A.BROOUNTITL IDENTIFICATION OF CYS255 IN HIF-1 ALPHA AS A NOVEL SITE FORTITL 2 DEVELOPMENT OF COVALENT INHIBITORS OF HIF-1 ALPHA /ARNT PASBTITL 3 DOMAIN PROTEIN-PROTEIN INTERACTION.REF PROTEIN SCI. V. 21 1885 2012REFN ISSN 0961-8368PMID 23033253DOI 10.1002/PRO.2172 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 106 |
| Number Of SNVs | 9 |
| Number Of Permutations | 3111 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.056 |
| p-value | 0.671 |