General Structure Information
| PDB ID | 3tw8 |
| HGNC Gene Label(s) | DENND1B |
| Structure Name | gef domain of dennd 1b in complex with rab gtpase rab35 |
| Resolution | 2.1Å |
| Reference | AUTH X.WU,M.J.BRADLEY,Y.CAI,D.KUMMEL,E.M.DE LA CRUZ,F.A.BARR,AUTH 2 K.M.REINISCHTITL INSIGHTS REGARDING GUANINE NUCLEOTIDE EXCHANGE FROM THETITL 2 STRUCTURE OF A DENN-DOMAIN PROTEIN COMPLEXED WITH ITS RABTITL 3 GTPASE SUBSTRATE.REF PROC.NATL.ACAD.SCI.USA V. 108 18672 2011REFN ISSN 0027-8424PMID 22065758DOI 10.1073/PNAS.1110415108 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 343 |
| Number Of SNVs | 89 |
| Number Of Permutations | 19734 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.059 |
| p-value | 0.415 |
COSMIC
| Number Of Residues | 343 |
| Number Of SNVs | 8 |
| Number Of Permutations | 4050 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.071 |
| p-value | 0.737 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 89 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.073 |
| p-value | 0.515 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
