General Structure Information
| PDB ID | 1g88 |
| HGNC Gene Label(s) | SMAD4 |
| Structure Name | s4afl3arg515 mutant |
| Resolution | 3.0Å |
| Reference | AUTH B.M.CHACKO,B.QIN,J.J.CORREIA,S.S.LAM,AUTH 2 M.P.DE CAESTECKER,K.LINTITL THE L3 LOOP AND C-TERMINAL PHOSPHORYLATION JOINTLYTITL 2 DEFINE SMAD PROTEIN TRIMERIZATION.REF NAT.STRUCT.BIOL. V. 8 248 2001REFN ISSN 1072-8368PMID 11224571DOI 10.1038/84995 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 221 |
| Number Of SNVs | 16 |
| Number Of Permutations | 6536 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.008 |
| p-value | 0.213 |
ClinVar
| Number Of Residues | 221 |
| Number Of SNVs | 20 |
| Number Of Permutations | 8301 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.142 |
| p-value | 0.003 |
COSMIC
| Number Of Residues | 221 |
| Number Of SNVs | 41 |
| Number Of Permutations | 7694 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.074 |
| p-value | 0.011 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 16 |
| Number Of ClinVar SNVs | 20 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.1 |
| p-value | 0.0 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 16 |
| Number Of COSMIC SNVs | 28 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.223 |
| p-value | 0.021 |