Assessment of Structural Intolerance and Durability
General Structure Information 1svc NFKB1 nfkb p50 homodimer bound to dna 2.6Å AUTH C.W.MULLER,F.A.REY,M.SODEOKA,G.L.VERDINE,AUTH 2 S.C.HARRISONTITL STRUCTURE OF THE NF-KAPPA B P50 HOMODIMER BOUND TOTITL 2 DNA.REF NATURE V. 373 311 1995REFN ISSN 0028-0836PMID 7830764DOI 10.1038/373311A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ga5 NR1D1 crystal structure of the orphan nuclear receptor rev- erb(alpha) dna-binding domain bound to its cognate response element 2.4Å AUTH M.L.SIERK,Q.ZHAO,F.RASTINEJADTITL DNA DEFORMABILITY AS A RECOGNITION FEATURE IN THETITL 2 REVERB RESPONSE ELEMENTREF BIOCHEMISTRY V. 40 12833 2001REFN ISSN 0006-2960PMID 11669620DOI 10.1021/BI011086R Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2krr NCL solution structure of the rbd1,2 domains from human nucleolin -1.0Å AUTH S.ARUMUGAM,M.C.MILLER,J.MALIEKAL,P.J.BATES,J.O.TRENT,AUTH 2 A.N.LANETITL SOLUTION STRUCTURE OF THE RBD1,2 DOMAINS FROM HUMANTITL 2 NUCLEOLIN.REF J.BIOMOL.NMR V. 47 79 2010REFN ISSN 0925-2738PMID 20376532DOI 10.1007/S10858-010-9412-1 Variant Set Distributions Mapped Variants
General Structure Information 3dzu RXRA intact ppar gamma – rxr alpha nuclear receptor complex on dna bound with bvt.13, 9-cis retinoic acid and ncoa2 peptide 3.2Å AUTH V.CHANDRA,P.HUANG,Y.HAMURO,S.RAGHURAM,Y.WANG,T.P.BURRIS,AUTH 2 F.RASTINEJADTITL STRUCTURE OF THE INTACT PPAR-GAMMA-RXR- NUCLEAR RECEPTORTITL 2 COMPLEX ON DNA.REF NATURE V. 456 350 2008REFN ISSN 0028-0836PMID 19043829DOI 10.1038/NATURE07413 Variant Set Distributions Ripley’s K […]
General Structure Information 2iwg TRIM21 complex between the pryspry domain of trim21 and igg fc 2.35Å AUTH L.C.JAMES,A.H.KEEBLE,Z.KHAN,D.A.RHODES,J.TROWSDALETITL STRUCTURAL BASIS FOR PRYSPRY-MEDIATED TRIPARTITETITL 2 MOTIF (TRIM) PROTEIN FUNCTION.REF PROC.NATL.ACAD.SCI.USA V. 104 6200 2007REFN ISSN 0027-8424PMID 17400754DOI 10.1073/PNAS.0609174104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2nll THRB retinoid x receptor-thyroid hormone receptor dna-binding domain heterodimer bound to thyroid response element dna 1.9Å AUTH F.RASTINEJAD,T.PERLMANN,R.M.EVANS,P.B.SIGLERTITL STRUCTURAL DETERMINANTS OF NUCLEAR RECEPTORTITL 2 ASSEMBLY ON DNA DIRECT REPEATS.REF NATURE V. 375 203 1995REFN ISSN 0028-0836PMID 7746322DOI 10.1038/375203A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ebl NR2F1 solution structure of the zinc finger, c4-type domain of human coup transcription factor 1 -1.0Å AUTH M.YONEYAMA,S.KOSHIBA,S.WATABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE ZINC FINGER, C4-TYPETITL 2 DOMAIN OF HUMAN COUP TRANSCRIPTION FACTOR 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2jvn PARP1 domain c of human parp-1 -1.0Å AUTH Z.TAO,P.GAO,D.W.HOFFMAN,H.W.LIUTITL DOMAIN C OF HUMAN POLY(ADP-RIBOSE) POLYMERASE-1 IS IMPORTANTTITL 2 FOR ENZYME ACTIVITY AND CONTAINS A NOVEL ZINC-RIBBON MOTIF.REF BIOCHEMISTRY V. 47 5804 2008REFN ISSN 0006-2960PMID 18452307DOI 10.1021/BI800018A Variant Set Distributions Mapped Variants
General Structure Information 4fm9 TOP2A human topoisomerase ii alpha bound to dna 2.9Å AUTH T.J.WENDORFF,B.H.SCHMIDT,P.HESLOP,C.A.AUSTIN,J.M.BERGERTITL THE STRUCTURE OF DNA-BOUND HUMAN TOPOISOMERASE II ALPHA:TITL 2 CONFORMATIONAL MECHANISMS FOR COORDINATING INTER-SUBUNITTITL 3 INTERACTIONS WITH DNA CLEAVAGE.REF J.MOL.BIOL. V. 424 109 2012REFN ISSN 0022-2836PMID 22841979DOI 10.1016/J.JMB.2012.07.014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3b97 ENO1 crystal structure of human enolase 1 2.2Å AUTH H.J.KANG,S.K.JUNG,S.J.KIM,S.J.CHUNGTITL STRUCTURE OF HUMAN ALPHA-ENOLASE (HENO1), ATITL 2 MULTIFUNCTIONAL GLYCOLYTIC ENZYME.REF ACTA CRYSTALLOGR.,SECT.D V. 64 651 2008REFN ISSN 0907-4449PMID 18560153DOI 10.1107/S0907444908008561 Variant Set Distributions Mapped Variants