General Structure Information
| PDB ID | 1ga5 |
| HGNC Gene Label(s) | NR1D1 |
| Structure Name | crystal structure of the orphan nuclear receptor rev- erb(alpha) dna-binding domain bound to its cognate response element |
| Resolution | 2.4Å |
| Reference | AUTH M.L.SIERK,Q.ZHAO,F.RASTINEJADTITL DNA DEFORMABILITY AS A RECOGNITION FEATURE IN THETITL 2 REVERB RESPONSE ELEMENTREF BIOCHEMISTRY V. 40 12833 2001REFN ISSN 0006-2960PMID 11669620DOI 10.1021/BI011086R |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 74 |
| Number Of SNVs | 13 |
| Number Of Permutations | 3944 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.051 |
| p-value | 0.884 |
COSMIC
| Number Of Residues | 74 |
| Number Of SNVs | 6 |
| Number Of Permutations | 832 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.067 |
| p-value | 0.539 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 13 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.372 |
| p-value | 0.557 |