Assessment of Structural Intolerance and Durability
General Structure Information 3fdt CBX5 crystal structure of the complex of human chromobox homolog 5 (cbx5) with h3k9(me)3 peptide 2.0Å AUTH L.KAUSTOV,H.OUYANG,M.AMAYA,A.LEMAK,N.NADY,S.DUAN,G.A.WASNEY,AUTH 2 Z.LI,M.VEDADI,M.SCHAPIRA,J.MIN,C.H.ARROWSMITHTITL RECOGNITION AND SPECIFICITY DETERMINANTS OF THE HUMAN CBXTITL 2 CHROMODOMAINS.REF J.BIOL.CHEM. V. 286 521 2011REFN ISSN 0021-9258PMID 21047797DOI 10.1074/JBC.M110.191411 Variant Set Distributions Mapped Variants
General Structure Information 2dbg MNDA solution structure of the pyrin (paad-dapin) domain in human myeloid cell nuclear differentiation antigen -1.0Å AUTH K.SAITO,M.INOUE,S.KOSHIBA,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PYRIN (PAAD-DAPIN)TITL 2 DOMAIN IN HUMAN MYELOID CELL NUCLEARTITL 3 DIFFERENTIATION ANTIGENREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3bim BCL6 crystal structure of the bcl6 btb domain dimer in complex with the bcor bbd corepressor peptide 2.6Å AUTH A.F.GHETU,C.M.CORCORAN,L.CERCHIETTI,V.J.BARDWELL,AUTH 2 A.MELNICK,G.G.PRIVETITL STRUCTURE OF A BCOR COREPRESSOR PEPTIDE IN COMPLEXTITL 2 WITH THE BCL6 BTB DOMAIN DIMER.REF MOL.CELL V. 29 384 2008REFN ISSN 1097-2765PMID 18280243DOI 10.1016/J.MOLCEL.2007.12.026 Variant Set Distributions Mapped Variants
General Structure Information 3cjw NR2F2 crystal structure of the human coup-tfii ligand binding domain 1.48Å AUTH S.W.KRUSE,K.SUINO-POWELL,X.E.ZHOU,J.E.KRETSCHMAN,AUTH 2 R.REYNOLDS,C.VONRHEIN,Y.XU,L.WANG,S.Y.TSAI,AUTH 3 M.J.TSAI,H.E.XUTITL IDENTIFICATION OF COUP-TFII ORPHAN NUCLEARTITL 2 RECEPTOR AS A RETINOIC ACID-ACTIVATED RECEPTOR.REF PLOS BIOL. V. 6 E227 2008REFN ISSN 1544-9173PMID 18798693DOI 10.1371/JOURNAL.PBIO.0060227 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2qw4 NR4A1 human nr4a1 ligand-binding domain 2.8Å AUTH J.R.MIN,A.SCHUETZ,P.LOPPNAU,J.WEIGELT,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOVTITL CRYSTAL STRUCTURE OF HUMAN NR4A1 LIGAND-BINDING DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3bbb NME2 crystal structure of the nm23-h2 transcription factor complex with dinucleotide d(ag) 1.3Å AUTH T.S.DEXHEIMER,S.S.CAREY,S.ZUOHE,V.M.GOKHALE,X.HU,L.B.MURATA,AUTH 2 E.M.MAES,A.WEICHSEL,D.SUN,E.J.MEUILLET,W.R.MONTFORT,AUTH 3 L.H.HURLEYTITL NM23-H2 MAY PLAY AN INDIRECT ROLE IN TRANSCRIPTIONALTITL 2 ACTIVATION OF C-MYC GENE EXPRESSION BUT DOES NOT CLEAVE THETITL 3 NUCLEASE HYPERSENSITIVE ELEMENT III1.REF MOL.CANCER THER. V. 8 1363 2009REFN ISSN 1535-7163PMID […]
General Structure Information 4awl NFYB the nf-y transcription factor is structurally and functionally a sequence specific histone 3.08Å AUTH M.NARDINI,N.GNESUTTA,G.DONATI,R.GATTA,C.FORNI,A.FOSSATI,AUTH 2 C.VONRHEIN,D.MORAS,C.ROMIER,M.BOLOGNESI,R.MANTOVANITITL SEQUENCE-SPECIFIC TRANSCRIPTION FACTOR NF-Y DISPLAYSTITL 2 HISTONE-LIKE DNA BINDING AND H2B-LIKE UBIQUITINATION.REF CELL(CAMBRIDGE,MASS.) V. 152 132 2013REFN ISSN 0092-8674PMID 23332751DOI 10.1016/J.CELL.2012.11.047 Variant Set Distributions Mapped Variants
General Structure Information 4awl NFYA the nf-y transcription factor is structurally and functionally a sequence specific histone 3.08Å AUTH M.NARDINI,N.GNESUTTA,G.DONATI,R.GATTA,C.FORNI,A.FOSSATI,AUTH 2 C.VONRHEIN,D.MORAS,C.ROMIER,M.BOLOGNESI,R.MANTOVANITITL SEQUENCE-SPECIFIC TRANSCRIPTION FACTOR NF-Y DISPLAYSTITL 2 HISTONE-LIKE DNA BINDING AND H2B-LIKE UBIQUITINATION.REF CELL(CAMBRIDGE,MASS.) V. 152 132 2013REFN ISSN 0092-8674PMID 23332751DOI 10.1016/J.CELL.2012.11.047 Variant Set Distributions Mapped Variants
General Structure Information 3f1p ARNT crystal structure of a high affinity heterodimer of hif2 alpha and arnt c-terminal pas domains 1.17Å AUTH T.H.SCHEUERMANN,D.R.TOMCHICK,M.MACHIUS,Y.GUO,AUTH 2 R.K.BRUICK,K.H.GARDNERTITL ARTIFICIAL LIGAND BINDING WITHIN THE HIF2ALPHATITL 2 PAS-B DOMAIN OF THE HIF2 TRANSCRIPTION FACTOR.REF PROC.NATL.ACAD.SCI.USA V. 106 450 2009REFN ISSN 0027-8424PMID 19129502DOI 10.1073/PNAS.0808092106 Variant Set Distributions Mapped Variants
General Structure Information 2hzd TEAD1 nmr structure of the dna-binding tea domain and insights into tef-1 function -1.0Å AUTH A.ANBANANDAM,D.C.ALBARADO,C.T.NGUYEN,G.HALDER,AUTH 2 X.GAO,S.VEERARAGHAVANTITL INSIGHTS INTO TRANSCRIPTION ENHANCER FACTOR 1TITL 2 (TEF-1) ACTIVITY FROM THE SOLUTION STRUCTURE OFTITL 3 THE TEA DOMAIN.REF PROC.NATL.ACAD.SCI.USA V. 103 17225 2006REFN ISSN 0027-8424PMID 17085591DOI 10.1073/PNAS.0607171103 Variant Set Distributions Mapped Variants