General Structure Information
| PDB ID | 4fm9 |
| HGNC Gene Label(s) | TOP2A |
| Structure Name | human topoisomerase ii alpha bound to dna |
| Resolution | 2.9Å |
| Reference | AUTH T.J.WENDORFF,B.H.SCHMIDT,P.HESLOP,C.A.AUSTIN,J.M.BERGERTITL THE STRUCTURE OF DNA-BOUND HUMAN TOPOISOMERASE II ALPHA:TITL 2 CONFORMATIONAL MECHANISMS FOR COORDINATING INTER-SUBUNITTITL 3 INTERACTIONS WITH DNA CLEAVAGE.REF J.MOL.BIOL. V. 424 109 2012REFN ISSN 0022-2836PMID 22841979DOI 10.1016/J.JMB.2012.07.014 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 727 |
| Number Of SNVs | 97 |
| Number Of Permutations | 68878 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.057 |
| p-value | 0.348 |
COSMIC
| Number Of Residues | 727 |
| Number Of SNVs | 6 |
| Number Of Permutations | 2674 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.333 |
| p-value | 0.475 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 97 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.03 |
| p-value | 0.594 |