Assessment of Structural Intolerance and Durability
General Structure Information 3qxl RALGPS1 crystal structure of the cdc25 domain from ral-specific guanine- nucleotide exchange factor ralgps1a 2.24Å AUTH W.PENG,J.XU,X.GUAN,Y.SUN,X.C.ZHANG,X.LI,Z.RAOTITL STRUCTURAL STUDY OF THE CDC25 DOMAIN FROM RAL-SPECIFICTITL 2 GUANINE-NUCLEOTIDE EXCHANGE FACTOR RALGPS1A.REF PROTEIN CELL V. 2 308 2011REFN ISSN 1674-800XPMID 21494904DOI 10.1007/S13238-011-1036-Z Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 4bou OTUD3 structure of otud3 otu domain 1.55Å AUTH T.E.T.MEVISSEN,M.K.HOSPENTHAL,P.P.GEURINK,P.R.ELLIOTT,AUTH 2 M.AKUTSU,N.ARNAUDO,R.EKKEBUS,Y.KULATHU,T.WAUER,F.EL OUALID,AUTH 3 S.M.V.FREUND,H.OVAA,D.KOMANDERTITL OTU DEUBIQUITINASES REVEAL MECHANISMS OF LINKAGETITL 2 SPECIFICITY AND ENABLE UBIQUITIN CHAIN RESTRICTIONTITL 3 ANALYSIS.REF CELL(CAMBRIDGE,MASS.) V. 154 169 2013REFN ISSN 0092-8674PMID 23827681DOI 10.1016/J.CELL.2013.05.046 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2dmi TSHZ3 solution structure of the first and the second zf-c2h2 like domains of human teashirt homolog 3 -1.0Å AUTH H.ENDO,F.HAYASHI,M.YOSHIDA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST AND THE SECONDTITL 2 ZF-C2H2 LIKE DOMAINS OF HUMAN TEASHIRT HOMOLOG 3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3l4h HECW1 helical box domain and second ww domain of the human e3 ubiquitin- protein ligase hecw1 1.8Å AUTH J.R.WALKER,L.QIU,Y.LI,J.WEIGELT,C.BOUNTRA,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL THE TANDEM HELICAL BOX AND SECOND WW DOMAINS OF HUMAN HECW1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2y96 DUPD1 structure of human dual-specificity phosphatase 27 2.38Å AUTH G.T.LOUNTOS,J.E.TROPEA,D.S.WAUGHTITL STRUCTURE OF HUMAN DUAL-SPECIFICITY PHOSPHATASETITL 2 AT 2.38A RESOLUTIONREF ACTA CRYSTALLOGR.,SECT.D V. 67 471 2011REFN ISSN 0907-4449PMID 21543850DOI 10.1107/S090744491100970X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3mpx FGD5 crystal structure of the dh and ph-1 domains of human fgd5 2.8Å AUTH Y.SHEN,L.NEDYALKOVA,Y.TONG,W.TEMPEL,L.CROMBET,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE DH AND PH-1 DOMAINS OF HUMAN FGD5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3blj PARP15 crystal structure of human poly(adp-ribose) polymerase 15, catalytic fragment 2.2Å AUTH T.KARLBERG,M.KLEPSCH,A.G.THORSELL,C.D.ANDERSSON,A.LINUSSON,AUTH 2 H.SCHULERTITL STRUCTURAL BASIS FOR LACK OF ADP-RIBOSYLTRANSFERASE ACTIVITYTITL 2 IN POLY(ADP-RIBOSE) POLYMERASE-13/ZINC FINGER ANTIVIRALTITL 3 PROTEIN.REF J.BIOL.CHEM. V. 290 7336 2015REFN ISSN 0021-9258PMID 25635049DOI 10.1074/JBC.M114.630160 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1fpz CDKN3 crystal structure analysis of kinase associated phosphatase (kap) with a substitution of the catalytic site cysteine (cys140) to a serine 2.0Å AUTH H.SONG,N.HANLON,N.R.BROWN,M.E.NOBLE,L.N.JOHNSON,AUTH 2 D.BARFORDTITL PHOSPHOPROTEIN-PROTEIN INTERACTIONS REVEALED BYTITL 2 THE CRYSTAL STRUCTURE OF KINASE-ASSOCIATEDTITL 3 PHOSPHATASE IN COMPLEX WITH PHOSPHOCDK2.REF MOL.CELL V. 7 615 2001REFN ISSN 1097-2765PMID 11463386DOI 10.1016/S1097-2765(01)00208-8 […]
General Structure Information 3r2w UGP2 crystal strucutre of udp-glucose pyrophosphorylase of homo sapiens 3.6Å AUTH Q.YU,X.ZHENGTITL THE CRYSTAL STRUCTURE OF HUMAN UDP-GLUCOSE PYROPHOSPHORYLASETITL 2 REVEALS A LATCH EFFECT THAT INFLUENCES ENZYMATIC ACTIVITY.REF BIOCHEM.J. V. 442 283 2012REFN ISSN 0264-6021PMID 22132858DOI 10.1042/BJ20111598 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2xt3 KIF7 human kif7, a kinesin involved in hedgehog signalling 1.88Å AUTH M.KLEJNOT,F.KOZIELSKITITL STRUCTURAL INSIGHTS INTO HUMAN KIF7, A KINESIN INVOLVED INTITL 2 HEDGEHOG SIGNALLING.REF ACTA CRYSTALLOGR.,SECT.D V. 68 154 2012REFN ISSN 0907-4449PMID 22281744DOI 10.1107/S0907444911053042 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants