General Structure Information
| PDB ID | 3r2w |
| HGNC Gene Label(s) | UGP2 |
| Structure Name | crystal strucutre of udp-glucose pyrophosphorylase of homo sapiens |
| Resolution | 3.6Å |
| Reference | AUTH Q.YU,X.ZHENGTITL THE CRYSTAL STRUCTURE OF HUMAN UDP-GLUCOSE PYROPHOSPHORYLASETITL 2 REVEALS A LATCH EFFECT THAT INFLUENCES ENZYMATIC ACTIVITY.REF BIOCHEM.J. V. 442 283 2012REFN ISSN 0264-6021PMID 22132858DOI 10.1042/BJ20111598 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 450 |
| Number Of SNVs | 70 |
| Number Of Permutations | 13947 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.196 |
| p-value | 0.062 |
COSMIC
| Number Of Residues | 450 |
| Number Of SNVs | 7 |
| Number Of Permutations | 3045 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.048 |
| p-value | 0.274 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 70 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | -0.131 |
| p-value | 0.889 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
