Assessment of Structural Intolerance and Durability
General Structure Information 2cfy TXNRD1 crystal structure of human thioredoxin reductase 1 2.7Å AUTH J.E.DEBRECZENI,C.JOHANSSON,K.KAVANAGH,P.SAVITSKY,AUTH 2 M.SUNDSTROM,C.ARROWSMITH,J.WEIGELT,A.EDWARDS,F.VON DELFT,AUTH 3 U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN THIOREDOXIN REDUCTASE 1REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2afo QPCT crystal structure of human glutaminyl cyclase at ph 8.0 2.35Å AUTH K.F.HUANG,Y.L.LIU,W.J.CHENG,T.P.KO,A.H.WANGTITL CRYSTAL STRUCTURES OF HUMAN GLUTAMINYL CYCLASE, AN ENZYMETITL 2 RESPONSIBLE FOR PROTEIN N-TERMINAL PYROGLUTAMATE FORMATIONREF PROC.NATL.ACAD.SCI.USA V. 102 13117 2005REFN ISSN 0027-8424PMID 16135565DOI 10.1073/PNAS.0504184102 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3of6 PTCRA human pre-t cell receptor crystal structure 2.8Å AUTH S.S.PANG,R.BERRY,Z.CHEN,L.KJER-NIELSEN,M.A.PERUGINI,AUTH 2 G.F.KING,C.WANG,S.H.CHEW,N.L.LA GRUTA,N.K.WILLIAMS,T.BEDDOE,AUTH 3 T.TIGANIS,N.P.COWIESON,D.I.GODFREY,A.W.PURCELL,M.C.J.WILCE,AUTH 4 J.MCCLUSKEY,J.ROSSJOHNTITL THE STRUCTURAL BASIS FOR AUTONOMOUS DIMERIZATION OF THETITL 2 PRE-T-CELL ANTIGEN RECEPTORREF NATURE V. 467 844 2010REFN ISSN 0028-0836PMID 20944746DOI 10.1038/NATURE09448 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3czh CYP2R1 crystal structure of cyp2r1 in complex with vitamin d2 2.3Å AUTH N.V.STRUSHKEVICH,W.TEMPEL,A.A.GILEP,P.LOPPNAU,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,M.WILKSTROM,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF CYP2R1 IN COMPLEX WITHTITL 2 VITAMIN D2.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2g59 PTPRO crystal structure of the catalytic domain of protein tyrosine phosphatase from homo sapiens 2.19Å AUTH S.C.ALMO,J.B.BONANNO,J.M.SAUDER,S.EMTAGE,AUTH 2 T.P.DILORENZO,V.MALASHKEVICH,S.R.WASSERMAN,AUTH 3 S.SWAMINATHAN,S.ESWARAMOORTHY,R.AGARWAL,D.KUMARAN,AUTH 4 M.MADEGOWDA,S.RAGUMANI,Y.PATSKOVSKY,J.ALVARADO,AUTH 5 U.A.RAMAGOPAL,J.FABER-BARATA,M.R.CHANCE,A.SALI,AUTH 6 A.FISER,Z.Y.ZHANG,D.S.LAWRENCE,S.K.BURLEYTITL STRUCTURAL GENOMICS OF PROTEIN PHOSPHATASES.REF J.STRUCT.FUNCT.GENOM. V. 8 121 2007REFN ISSN 1345-711XPMID 18058037DOI 10.1007/S10969-007-9036-1 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2dwp PFKFB3 a pseudo substrate complex of 6-phosphofructo-2-kinase of pfkfb 2.7Å AUTH S.G.KIM,M.CAVALIER,M.R.EL-MAGHRABI,Y.H.LEETITL A DIRECT SUBSTRATE-SUBSTRATE INTERACTION FOUND INTITL 2 THE KINASE DOMAIN OF THE BIFUNCTIONAL ENZYME,TITL 3 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-TITL 4 BISPHOSPHATASEREF J.MOL.BIOL. V. 370 14 2007REFN ISSN 0022-2836PMID 17499765DOI 10.1016/J.JMB.2007.03.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3kv5 KDM7A structure of kiaa1718, human jumonji demethylase, in complex with n-oxalylglycine 2.39Å AUTH J.R.HORTON,A.K.UPADHYAY,H.H.QI,X.ZHANG,Y.SHI,AUTH 2 X.CHENGTITL ENZYMATIC AND STRUCTURAL INSIGHTS FOR SUBSTRATETITL 2 SPECIFICITY OF A FAMILY OF JUMONJI HISTONE LYSINETITL 3 DEMETHYLASES.REF NAT.STRUCT.MOL.BIOL. V. 17 38 2010REFN ISSN 1545-9993PMID 20023638DOI 10.1038/NSMB.1753 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 4at4 NTRK2 crystal structure of trkb kinase domain in complex with ex429 2.36Å AUTH T.BERTRAND,M.KOTHE,J.LIU,A.DUPUY,A.RAK,P.F.BERNE,S.DAVIS,AUTH 2 T.GLADYSHEVA,C.VALTRE,J.Y.CRENNE,M.MATHIEUTITL THE CRYSTAL STRUCTURES OF TRKA AND TRKB SUGGEST KEY REGIONSTITL 2 FOR ACHIEVING SELECTIVE INHIBITION.REF J.MOL.BIOL. V. 423 439 2012REFN ISSN 0022-2836PMID 22902478DOI 10.1016/J.JMB.2012.08.002 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 1w7n CCBL1 crystal structure of human kynurenine aminotransferase i in pmp form 2.9Å AUTH F.ROSSI,Q.HAN,J.LI,J.LI,M.RIZZITITL CRYSTAL STRUCTURE OF HUMAN KYNURENINETITL 2 AMINOTRANSFERASE IREF J.BIOL.CHEM. V. 279 50214 2004REFN ISSN 0021-9258PMID 15364907DOI 10.1074/JBC.M409291200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1u7v SMAD2 crystal structure of the phosphorylated smad2/smad4 heterotrimeric complex 2.7Å AUTH B.M.CHACKO,B.Y.QIN,A.TIWARI,G.SHI,S.LAM,AUTH 2 L.J.HAYWARD,M.DE CAESTECKER,K.LINTITL STRUCTURAL BASIS OF HETEROMERIC SMAD PROTEINTITL 2 ASSEMBLY IN TGF-BETA SIGNALINGREF MOL.CELL V. 15 813 2004REFN ISSN 1097-2765PMID 15350224DOI 10.1016/J.MOLCEL.2004.07.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants