Assessment of Structural Intolerance and Durability
General Structure Information 4dlj MAPK14 human p38 map kinase in complex with rl163 2.6Å AUTH M.GETLIK,J.R.SIMARD,M.TERMATHE,C.GRUTTER,M.RABILLER,AUTH 2 W.A.VAN OTTERLO,D.RAUHTITL FLUOROPHORE LABELED KINASE DETECTS LIGANDS THAT BIND WITHINTITL 2 THE MAPK INSERT OF P38ALPHA KINASE.REF PLOS ONE V. 7 39713 2012REFN ESSN 1932-6203PMID 22768308DOI 10.1371/JOURNAL.PONE.0039713 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 4gwm MEP1B crystal structure of human promeprin beta 1.85Å AUTH J.L.AROLAS,C.BRODER,T.JEFFERSON,T.GUEVARA,E.E.STERCHI,AUTH 2 W.BODE,W.STOCKER,C.BECKER-PAULY,F.X.GOMIS-RUTHTITL STRUCTURAL BASIS FOR THE SHEDDASE FUNCTION OF HUMAN MEPRINTITL 2 BETA METALLOPROTEINASE AT THE PLASMA MEMBRANEREF PROC.NATL.ACAD.SCI.USA V. 109 16131 2012REFN ISSN 0027-8424PMID 22988105DOI 10.1073/PNAS.1211076109 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3sqd PAXIP1 crystal structure of human ptip brct5/6-gamma h2ax complex 2.15Å AUTH W.YAN,Z.H.SHAOTITL CRYSTAL STRUCTURE OF HUMAN PTIP BRCT5/6-GAMMA H2AXREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3v2b PARP15 human poly(adp-ribose) polymerase 15 (artd7, bal3), macro domain 2 in complex with adenosine-5-diphosphoribose 2.2Å AUTH A.H.FORST,T.KARLBERG,N.HERZOG,A.G.THORSELL,A.GROSS,AUTH 2 K.L.FEIJS,P.VERHEUGD,P.KURSULA,B.NIJMEIJER,E.KREMMER,AUTH 3 H.KLEINE,A.G.LADURNER,H.SCHULER,B.LUSCHERTITL RECOGNITION OF MONO-ADP-RIBOSYLATED ARTD10 SUBSTRATES BYTITL 2 ARTD8 MACRODOMAINS.REF STRUCTURE V. 21 462 2013REFN ISSN 0969-2126PMID 23473667DOI 10.1016/J.STR.2012.12.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1us7 CDC37 complex of hsp90 and p50 2.3Å AUTH S.M.ROE,M.M.U.ALI,P.MEYER,C.K.VAUGHAN,B.PANARETOU,P.W.PIPER,AUTH 2 C.PRODROMOU,L.H.PEARLTITL THE MECHANISM OF HSP90 REGULATION BY THE PROTEINTITL 2 KINASE-SPECIFIC COCHAPERONE P50(CDC37)REF CELL(CAMBRIDGE,MASS.) V. 116 87 2004REFN ISSN 0092-8674PMID 14718169DOI 10.1016/S0092-8674(03)01027-4 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2hzp KYNU crystal structure of homo sapiens kynureninase 2.0Å AUTH S.LIMA,R.KHRISTOFOROV,C.MOMANY,R.S.PHILLIPSTITL CRYSTAL STRUCTURE OF HOMO SAPIENS KYNURENINASE.REF BIOCHEMISTRY V. 46 2735 2007REFN ISSN 0006-2960PMID 17300176DOI 10.1021/BI0616697 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4mtl METTL21C human methyltransferase-like protein 21c 1.65Å AUTH B.S.HONG,W.TEMPEL,A.DONG,Y.LI,C.H.ARROWSMITH,C.BOUNTRA,AUTH 2 A.M.EDWARDS,P.J.BROWNTITL HUMAN METHYLTRANSFERASE-LIKE PROTEIN 21CREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2i7a CAPN13 domain iv of human calpain 13 1.8Å AUTH J.R.WALKER,K.NG,T.L.DAVIS,R.RAVULAPALLI,C.BUTLER-COLE,AUTH 2 P.J.FINERTY JR.,E.M.NEWMAN,J.WEIGELT,M.SUNDSTROM,AUTH 3 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,S.DHE-PAGANONTITL STRUCTURE OF HUMAN CALPAIN 13REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4ah6 DARS2 human mitochondrial aspartyl-trna synthetase 3.7Å AUTH E.ENNIFAR,C.FLORENTZ,A.GAUDRY,B.LORBER,A.NEUENFELDT,AUTH 2 C.SAUTER,M.SISSLERTITL THERMODYNAMIC PROPERTIES DISTINGUISH HUMAN MITOCHONDRIALTITL 2 ASPARTYL-TRNA SYNTHETASE FROM BACTERIAL HOMOLOG WITH SAMETITL 3 3D ARCHITECTUREREF NUCLEIC ACIDS RES. V. 41 2698 2013REFN ISSN 0305-1048PMID 23275545DOI 10.1093/NAR/GKS1322 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3bo5 SETMAR crystal structure of methyltransferase domain of human histone-lysine n-methyltransferase setmar 1.59Å AUTH H.WU,V.V.LUNIN,H.REN,E.DOBROVETSKY,J.WEIGELT,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,J.MIN,A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF METHYLTRANSFERASE DOMAIN OF HUMANTITL 2 HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR IN COMPLEX WITHTITL 3 ADOHCY.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants