General Structure Information
| PDB ID | 1u7v |
| HGNC Gene Label(s) | SMAD2 |
| Structure Name | crystal structure of the phosphorylated smad2/smad4 heterotrimeric complex |
| Resolution | 2.7Å |
| Reference | AUTH B.M.CHACKO,B.Y.QIN,A.TIWARI,G.SHI,S.LAM,AUTH 2 L.J.HAYWARD,M.DE CAESTECKER,K.LINTITL STRUCTURAL BASIS OF HETEROMERIC SMAD PROTEINTITL 2 ASSEMBLY IN TGF-BETA SIGNALINGREF MOL.CELL V. 15 813 2004REFN ISSN 1097-2765PMID 15350224DOI 10.1016/J.MOLCEL.2004.07.016 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 194 |
| Number Of SNVs | 13 |
| Number Of Permutations | 5624 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.192 |
| p-value | 0.664 |
COSMIC
| Number Of Residues | 194 |
| Number Of SNVs | 3 |
| Number Of Permutations | 204 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.333 |
| p-value | 0.719 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 13 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.244 |
| p-value | 0.833 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
