General Structure Information
| PDB ID | 2xt3 |
| HGNC Gene Label(s) | KIF7 |
| Structure Name | human kif7, a kinesin involved in hedgehog signalling |
| Resolution | 1.88Å |
| Reference | AUTH M.KLEJNOT,F.KOZIELSKITITL STRUCTURAL INSIGHTS INTO HUMAN KIF7, A KINESIN INVOLVED INTITL 2 HEDGEHOG SIGNALLING.REF ACTA CRYSTALLOGR.,SECT.D V. 68 154 2012REFN ISSN 0907-4449PMID 22281744DOI 10.1107/S0907444911053042 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 300 |
| Number Of SNVs | 32 |
| Number Of Permutations | 5604 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.062 |
| p-value | 0.405 |
COSMIC
| Number Of Residues | 300 |
| Number Of SNVs | 7 |
| Number Of Permutations | 1174 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.095 |
| p-value | 0.732 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 32 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | -0.088 |
| p-value | 0.985 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
